PMID- 34235247
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210709
IS  - 2363-9822 (Electronic)
IS  - 0003-9438 (Print)
IS  - 0003-9438 (Linking)
VI  - 64
IP  - 1
DP  - 2021
TI  - Characteristics of Tibetan pig lung tissue in response to a hypoxic environment 
      on the Qinghai-Tibet Plateau.
PG  - 283-292
LID - 10.5194/aab-64-283-2021 [doi]
AB  - To adapt to the plateau environment, Tibetan pigs' lungs have developed a unique 
      physiological mechanism during evolution. The vascular corrosion casting 
      technique and scanning electron microscopy were used to understand arterial 
      architecture. Blood physiological index and quantitative real-time PCR (qRT-PCR) 
      were used for assessing whether the lung can regulate the body through 
      anatomical, physiological and molecular mechanisms to adapt to hypoxic 
      environments. Our study showed that the lungs of Tibetan pigs were heavier and 
      wider and that the pulmonary arteries were thicker and branched and had a denser 
      vascular network than those of Landrace pigs. The hemoglobin (HGB), mean 
      corpuscular hemoglobin concentration (MCHC) values of high-altitude pigs were 
      significantly higher than those of low-altitude pigs. The expression levels of 
      HIF- 1 alpha , EPAS1, EPO and VEGF, but not those of eNOSand EGLN1, were 
      significantly higher in the lungs of high-altitude pigs than in those from pigs 
      at a lower altitude ( P<0.05 ). These findings and a comprehensive analysis help 
      elucidate the pulmonary mechanism of hypoxic adaptation in pigs.
CI  - Copyright: (c) 2021 Yanan Yang et al.
FAU - Yang, Yanan
AU  - Yang Y
AD  - College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 
      730070, China.
FAU - Gao, Caixia
AU  - Gao C
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
FAU - Yang, Tianliang
AU  - Yang T
AD  - College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 
      730070, China.
FAU - Sha, Yuzhu
AU  - Sha Y
AD  - College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 
      730070, China.
FAU - Cai, Yuan
AU  - Cai Y
AD  - College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 
      730070, China.
FAU - Wang, Xinrong
AU  - Wang X
AD  - College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 
      730070, China.
FAU - Yang, Qiaoli
AU  - Yang Q
AD  - College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 
      730070, China.
FAU - Liu, Chengze
AU  - Liu C
AD  - College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 
      730070, China.
FAU - Wang, Biao
AU  - Wang B
AD  - College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 
      730070, China.
FAU - Zhao, Shengguo
AU  - Zhao S
AD  - College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 
      730070, China.
LA  - eng
PT  - Journal Article
DEP - 20210628
PL  - Germany
TA  - Arch Anim Breed
JT  - Archives animal breeding
JID - 101701238
PMC - PMC8253108
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/07/09 06:00
MHDA- 2021/07/09 06:01
PMCR- 2021/06/28
CRDT- 2021/07/08 06:46
PHST- 2021/03/24 00:00 [received]
PHST- 2021/05/18 00:00 [accepted]
PHST- 2021/07/08 06:46 [entrez]
PHST- 2021/07/09 06:00 [pubmed]
PHST- 2021/07/09 06:01 [medline]
PHST- 2021/06/28 00:00 [pmc-release]
AID - 01021829 [pii]
AID - 10.5194/aab-64-283-2021 [doi]
PST - epublish
SO  - Arch Anim Breed. 2021 Jun 28;64(1):283-292. doi: 10.5194/aab-64-283-2021. 
      eCollection 2021.