PMID- 34236473
OWN - NLM
STAT- MEDLINE
DCOM- 20211116
LR  - 20211116
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 259
IP  - 12
DP  - 2021 Dec
TI  - Ocular perfusion in patients with reduced left ventricular ejection fraction 
      measured by optical coherence tomography angiography.
PG  - 3605-3611
LID - 10.1007/s00417-021-05253-6 [doi]
AB  - AIMS: The aim of this study is to evaluate retinal and optic nerve head (ONH) 
      perfusion in patients with systolic chronic heart failure (CHF) compared to 
      healthy control subjects. METHODS: Twenty-seven eyes of 27 patients with CHF 
      (study group) and 31 eyes of 31 healthy subjects (control group) were 
      prospectively included in this study. CHF Patients had a left ventricular 
      ejection fraction (LVEF) < 50% and were classified by New York Heart Association 
      (NYHA) class. OCT-A was performed using RTVue XR Avanti with AngioVue (Optovue, 
      Inc, Fremont, CA, USA). The area of the foveal avascular zone (FAZ) and flow 
      density (FD) data were extracted and analyzed. RESULTS: There was no significant 
      difference in the signal strength index between the study group (group 1) and the 
      control group (group 2) (ONH: p = 0.015; macula: p = 0.703). The difference in 
      the area of the foveal avascular zone between the two groups was also not 
      significant (p = 0.726). The flow density (whole en face) in the ONH (RPC) in 
      group 1 was significantly lower compared to control (group 1 = 48.40 +/- 2.48 (49.0 
      [46.7, 50.3]); group 2 = 50.15 +/- 1.85 (50.6 [48.5, 51.70]); p = 0.008). There was 
      a significant and strong correlation between LVEF and the macular flow density 
      (whole en face) (superficial: rs = 0.605 deep: rs = 0.425, p < 0.01). 
      CONCLUSIONS: Patients with CHF showed reduced flow density compared with healthy 
      controls. The reduced FD correlated with the LVEF and the functional (NYHA) 
      class. Retinal perfusion as measured using OCTA might provide an insight into the 
      global microperfusion and hemodynamic state of heart failure patients.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Alnawaiseh, Maged
AU  - Alnawaiseh M
AD  - Department of Ophthalmology, Klinikum Fulda gAG, Hospital Fulda, University of 
      Marburg, Campus Fulda, Fulda, Germany. Maged.Alnawaiseh@klinikum-fulda.de.
AD  - Department of Ophthalmology, University of Muenster Medical Center, Muenster, 
      Germany. Maged.Alnawaiseh@klinikum-fulda.de.
FAU - Eckardt, Franziska
AU  - Eckardt F
AD  - Department of Ophthalmology, University of Muenster Medical Center, Muenster, 
      Germany.
FAU - Mihailovic, Natasa
AU  - Mihailovic N
AD  - Department of Ophthalmology, Klinikum Fulda gAG, Hospital Fulda, University of 
      Marburg, Campus Fulda, Fulda, Germany.
AD  - Department of Ophthalmology, University of Muenster Medical Center, Muenster, 
      Germany.
FAU - Frommeyer, Gerrit
AU  - Frommeyer G
AD  - Division of Electrophysiology, Department of Cardiovascular Medicine, University 
      Hospital Muenster, Muenster, Germany.
FAU - Diener, Raphael
AU  - Diener R
AD  - Department of Ophthalmology, University of Muenster Medical Center, Muenster, 
      Germany.
FAU - Rosenberger, Friederike
AU  - Rosenberger F
AD  - Department of Ophthalmology, University of Muenster Medical Center, Muenster, 
      Germany.
FAU - Eckardt, Lars
AU  - Eckardt L
AD  - Division of Electrophysiology, Department of Cardiovascular Medicine, University 
      Hospital Muenster, Muenster, Germany.
FAU - Eter, Nicole
AU  - Eter N
AD  - Department of Ophthalmology, University of Muenster Medical Center, Muenster, 
      Germany.
FAU - Lahme, Larissa
AU  - Lahme L
AD  - Department of Ophthalmology, University of Muenster Medical Center, Muenster, 
      Germany.
FAU - Lange, Philipp Sebastian
AU  - Lange PS
AD  - Division of Electrophysiology, Department of Cardiovascular Medicine, University 
      Hospital Muenster, Muenster, Germany.
LA  - eng
PT  - Journal Article
DEP - 20210708
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Fluorescein Angiography
MH  - Humans
MH  - Perfusion
MH  - *Retinal Vessels/diagnostic imaging
MH  - Stroke Volume
MH  - *Tomography, Optical Coherence
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Cardiovascular diseases
OT  - Heart failure
OT  - Optic nerve and macular perfusion
OT  - Optical coherence tomography angiography
OT  - Reduced left ventricular ejection fraction
EDAT- 2021/07/09 06:00
MHDA- 2021/11/17 06:00
CRDT- 2021/07/08 12:23
PHST- 2021/01/14 00:00 [received]
PHST- 2021/05/19 00:00 [accepted]
PHST- 2021/05/15 00:00 [revised]
PHST- 2021/07/09 06:00 [pubmed]
PHST- 2021/11/17 06:00 [medline]
PHST- 2021/07/08 12:23 [entrez]
AID - 10.1007/s00417-021-05253-6 [pii]
AID - 10.1007/s00417-021-05253-6 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2021 Dec;259(12):3605-3611. doi: 
      10.1007/s00417-021-05253-6. Epub 2021 Jul 8.