PMID- 34236827
OWN - NLM
STAT- MEDLINE
DCOM- 20220318
LR  - 20220318
IS  - 1734-154X (Electronic)
IS  - 0001-527X (Linking)
VI  - 68
IP  - 4
DP  - 2021 Jul 8
TI  - MiR-22-3p Expression is down-regulated in lung adenocarcinoma.
PG  - 667-672
LID - 10.18388/abp.2020_5540 [doi]
AB  - BACKGROUND: Our current study was performed with an attempt to detect the 
      expression of microRNA-22-3p (miR-22-3p) in lung adenocarcinoma, as well as to 
      analyze its role in clinical practice. In addition, its relationship with 
      vascular endothelial growth factor (VEGF) and metastasis related indexes was 
      focused. MATERIAL AND METHOD: The trials in which 62 cases of lung adenocarcinoma 
      were received to collect tumor tissue (study group) and normal lung tissue 
      (control group) were eligible for this study. The expression of miR-22-3p in the 
      two groups was detected through RT-PCR. Immunohistochemical method was used to 
      detect the expression of VEGF and leukocyte differentiation antigen 31 (CD31) 
      marked microvessel density (MVD) in lung adenocarcinoma. The expressions of 
      matrix metalloproteinase-3 (MMP-3) and matrix metalloproteinase-7 (MMP-7) in lung 
      adenocarcinoma were also detected through the use of Western Blot. RESULTS: The 
      present study revealed significant difference in the expression of miR-22-3p 
      between the two groups. No significant difference in the expression of gender, 
      age, neural invasion and the number of lesions were observed between groups. 
      There was significant difference in the expression of miR-22-3p in the maximum 
      diameter of tumor, pleural recidivism, vascular recidivism, lymph node metastasis 
      and different TNM stages. Based on survival analysis, miR-22-3p was linked to 
      survival time. Correlation analysis indicated that there was negative correlation 
      between miR-22-3p and VEGF, miR-22-3p and MVD, miR-22-3p and MMP-3, and miR-22-3p 
      and MMP-7 in lung adenocarcinoma. CONCLUSION: Our findings provide evidence that 
      miR-22-3p is low expressed in lung adenocarcinoma tissues and the low expression 
      of miR-22-3p is closely associated with clinicopathological characteristics and 
      the prognosis. MiR-22-3p may be involved in the tumor progression of lung 
      adenocarcinoma and may serve as a biomarker for the diagnosis and prognosis of 
      lung adenocarcinoma.
FAU - Ma, Dong-Jie
AU  - Ma DJ
AD  - Department of Thoracic Surgery, Peking Union Medical College Hospital, CAMS and 
      PUMC, Beijing, 100730, China.
FAU - Zhou, Xiao-Yun
AU  - Zhou XY
AD  - Department of Thoracic Surgery, Peking Union Medical College Hospital, CAMS and 
      PUMC, Beijing, 100730, China.
FAU - Qin, Ying-Zhi
AU  - Qin YZ
AD  - Department of Thoracic Surgery, Peking Union Medical College Hospital, CAMS and 
      PUMC, Beijing, 100730, China.
FAU - Tian, Zhen-Huan
AU  - Tian ZH
AD  - Department of Thoracic Surgery, Peking Union Medical College Hospital, CAMS and 
      PUMC, Beijing, 100730, China.
FAU - Liu, Hong-Sheng
AU  - Liu HS
AD  - Department of Thoracic Surgery, Peking Union Medical College Hospital, CAMS and 
      PUMC, Beijing, 100730, China.
FAU - Li, Shan-Qing
AU  - Li SQ
AD  - Department of Thoracic Surgery, Peking Union Medical College Hospital, CAMS and 
      PUMC, Beijing, 100730, China.
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Acta Biochim Pol
JT  - Acta biochimica Polonica
JID - 14520300R
RN  - 0 (MIRN22 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Adenocarcinoma of Lung/blood supply/*genetics
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Down-Regulation
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/blood supply/*genetics
MH  - Male
MH  - MicroRNAs/*genetics
MH  - Middle Aged
EDAT- 2021/07/09 06:00
MHDA- 2022/03/19 06:00
CRDT- 2021/07/08 16:44
PHST- 2020/11/06 00:00 [received]
PHST- 2020/12/17 00:00 [accepted]
PHST- 2021/07/09 06:00 [pubmed]
PHST- 2022/03/19 06:00 [medline]
PHST- 2021/07/08 16:44 [entrez]
AID - 5540 [pii]
AID - 10.18388/abp.2020_5540 [doi]
PST - ppublish
SO  - Acta Biochim Pol. 2021 Jul 8;68(4):667-672. doi: 10.18388/abp.2020_5540.