PMID- 34238118
OWN - NLM
STAT- MEDLINE
DCOM- 20220429
LR  - 20220429
IS  - 1747-0927 (Electronic)
IS  - 1747-0919 (Linking)
VI  - 16
IP  - 5
DP  - 2021 Oct
TI  - Neural coding of human values is underpinned by brain areas representing the core 
      self in the cortical midline region.
PG  - 486-499
LID - 10.1080/17470919.2021.1953582 [doi]
AB  - The impact of human values on our choices depends on their nature. 
      Self-Transcendence values motivate us to act for the benefit of others and care 
      for the environment. Self-Enhancement values motivate us to act for our benefit. 
      The present study examines differences in the neural processes underlying these 
      two value domains. Extending our previous research, we used fMRI to explore first 
      of all neural correlates of Self-Transcendence vs Self-Enhancement values, with a 
      particular focus on the putative role of the medial prefrontal cortex (MPFC), 
      which has been linked to a self-transcendent mind-set. Additionally, we 
      investigated the neural basis of Openness to Change vs Conservation values. We 
      asked participants to reflect on and rate values as guiding principles in their 
      lives while undergoing fMRI. Mental processing of Self-Transcendence values was 
      associated with higher brain activity in the dorsomedial (BA9, BA8) and 
      ventromedial (BA10) prefrontal cortices, as compared to Self-Enhancement values. 
      The former involved activation and the latter deactivation of those regions. We 
      did not detect differences in brain activation between Openness to Change vs 
      Conservation values. Self-Transcendence values thus shared brain regions with 
      social processes that have previously been linked to a self-transcendent 
      mind-set, and the "core self" representation.
FAU - Leszkowicz, Emilia
AU  - Leszkowicz E
AD  - Department of Animal and Human Physiology, University of Gdansk, Gdansk, Poland.
AD  - School of Psychology, Cardiff University, Cardiff, UK.
FAU - Maio, Gregory R
AU  - Maio GR
AD  - Department of Psychology, University of Bath, Bath, UK.
FAU - Linden, David E J
AU  - Linden DEJ
AD  - School for Mental Health and Neuroscience, Maastricht University, Maastricht, 
      Netherlands.
FAU - Ihssen, Niklas
AU  - Ihssen N
AD  - Department of Psychology, Durham University, Durham, UK.
LA  - eng
GR  - MR/L010305/1/MRC_/Medical Research Council/United Kingdom
GR  - DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210720
PL  - England
TA  - Soc Neurosci
JT  - Social neuroscience
JID - 101279009
SB  - IM
MH  - *Brain/diagnostic imaging/physiology
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Prefrontal Cortex/diagnostic imaging
OTO - NOTNLM
OT  - Basic human values/Schwartz's value model
OT  - fMRI
OT  - self-enhancement
OT  - self-transcendence
EDAT- 2021/07/10 06:00
MHDA- 2022/04/30 06:00
CRDT- 2021/07/09 05:37
PHST- 2021/07/10 06:00 [pubmed]
PHST- 2022/04/30 06:00 [medline]
PHST- 2021/07/09 05:37 [entrez]
AID - 10.1080/17470919.2021.1953582 [doi]
PST - ppublish
SO  - Soc Neurosci. 2021 Oct;16(5):486-499. doi: 10.1080/17470919.2021.1953582. Epub 
      2021 Jul 20.