PMID- 34239927
OWN - NLM
STAT- MEDLINE
DCOM- 20211018
LR  - 20220424
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2021
DP  - 2021
TI  - Electrophysiological Evidence of Auditory and Cognitive Processing Deficits in 
      Parkinson Disease.
PG  - 6610908
LID - 10.1155/2021/6610908 [doi]
LID - 6610908
AB  - BACKGROUND: Parkinson's disease (PD) patients are at increased risk for central 
      auditory processing (CAP) deficits and cognitive dysfunction. However, behavioral 
      assessments of CAP and cognitive processing used in a previous study by our 
      research team found few significant differences in performance between 
      early-stage PD patients and age-matched control subjects. The objective of this 
      study is to use auditory event-related potentials (AERPs) to compare CAP and 
      cognitive functions in a population of PD patients with a group of age-matched 
      control subjects. METHODS: AERPs in response to tonal and speech stimuli were 
      recorded from 35 adults who had a medical diagnosis of PD (23 males and 12 
      females; mean age = 66.9 +/- s.d.11.2 years), and 35 age-matched control subjects 
      who did not have PD or any other neurological disorders (31 males and 4 females; 
      mean age = 65.4 +/- s.d.12.3 years). Auditory stimuli included pure tones (500 and 
      1000 Hz) to elicit the P300 response and a dichotic digits paradigm to elicit the 
      N200 processing negativity. RESULTS: Compared to control subjects, PD patients 
      exhibited significantly longer latencies of P300 and N200 components and smaller 
      amplitude N200 components. Latency and amplitude of the N200 component were 
      significantly correlated with participants' age. N200 amplitude was correlated 
      with results from the Rey Auditory Verbal Learning Test (RAVLT) of cognitive 
      ability. Latency of the P300 and amplitude of the N200 components were 
      significantly correlated with results from the Spatial Release From Masking (SRM) 
      behavioral CAP assessment. CONCLUSIONS: AERP assessments used in this study 
      appear to be sensitive indicators of CAP and cognitive deficits exhibited by 
      early-stage PD patients. While few significant differences in performance on 
      behavioral CAP and cognitive tests were previously observed between this 
      population of PD patients and age-matched control subjects, N200 and P300 
      components recorded in the present study revealed impaired neural processing by 
      the PD group.
CI  - Copyright (c) 2021 Robert L. Folmer et al.
FAU - Folmer, Robert L
AU  - Folmer RL
AUID- ORCID: 0000-0001-5113-5691
AD  - National Center for Rehabilitative Auditory Research, VA Portland Medical Center, 
      Portland, Oregon, USA.
AD  - Department of Otolaryngology, Oregon Health & Science University, Portland, 
      Oregon, USA.
FAU - Vachhani, Jay J
AU  - Vachhani JJ
AD  - National Center for Rehabilitative Auditory Research, VA Portland Medical Center, 
      Portland, Oregon, USA.
FAU - Riggins, Amy
AU  - Riggins A
AD  - Department of Communication Sciences & Disorders, University of Wisconsin, 
      Madison, USA.
LA  - eng
PT  - Journal Article
DEP - 20210618
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
SB  - IM
MH  - Aged
MH  - Audiometry
MH  - Audiometry, Pure-Tone
MH  - Auditory Perceptual Disorders/*complications/physiopathology
MH  - Behavior
MH  - Brain/physiopathology
MH  - Case-Control Studies
MH  - Cognition Disorders/*complications/physiopathology
MH  - Cognitive Dysfunction/physiopathology
MH  - Electrophysiology/*methods
MH  - Event-Related Potentials, P300/physiology
MH  - Evoked Potentials
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Parkinson Disease/*complications/physiopathology
PMC - PMC8233099
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2021/07/10 06:00
MHDA- 2021/10/21 06:00
PMCR- 2021/06/18
CRDT- 2021/07/09 07:01
PHST- 2020/10/08 00:00 [received]
PHST- 2021/05/03 00:00 [revised]
PHST- 2021/05/27 00:00 [accepted]
PHST- 2021/07/09 07:01 [entrez]
PHST- 2021/07/10 06:00 [pubmed]
PHST- 2021/10/21 06:00 [medline]
PHST- 2021/06/18 00:00 [pmc-release]
AID - 10.1155/2021/6610908 [doi]
PST - epublish
SO  - Biomed Res Int. 2021 Jun 18;2021:6610908. doi: 10.1155/2021/6610908. eCollection 
      2021.