PMID- 34239991
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220424
IS  - 2424-810X (Electronic)
IS  - 2382-6533 (Print)
IS  - 2382-6533 (Linking)
VI  - 7
IP  - 3
DP  - 2021 Jun 26
TI  - Cirrhotics with Monocyte Chemotactic Protein 1 Polymorphism are at Higher Risk 
      for Developing Spontaneous Bacterial Peritonitis - A Cohort Study.
PG  - 320-325
AB  - BACKGROUND: Spontaneous bacterial peritonitis (SBP) is a complication of liver 
      cirrhosis and its occurrence portends poor patient survival. There is emerging 
      evidence that genetic predisposition could significantly alter the occurrence and 
      course of SBP. Monocyte chemotactic protein 1 (MCP1) is a potent chemokine that 
      perpetuates the pro-inflammatory milieu in SBP. AIM: This study aimed at 
      investigating MCP1 genotype polymorphism and its survival impact in patients with 
      decompensated liver cirrhosis. METHODS: We recruited 107 individuals with 
      decompensated liver cirrhosis and categorized them into two groups. Patients 
      having SBP formed the cases (Group 1) and controls were patients without SBP 
      (Group 2). MCP1 polymorphism (-2518A/G) was assessed in both groups by 
      restriction fragment length polymorphism method. The Chi-square test was used to 
      assess the differences in categorical variables and Kaplan-Meier analyses were 
      used to assess the survival. RESULTS: Patients with SBP (36.5%) had higher 
      frequency of G allele than patients without SBP (23%) (P=0.031; odds ratio=1.955, 
      95% confidence interval: 1.0553-3.6216). Kaplan-Meir analysis revealed that 
      presence of SBP (P=0.030) and G allele (P=0.021) had significantly reduced the 
      likelihood of survival among cirrhotics. CONCLUSIONS: Cirrhotic patients with 
      MCP1 G allele have a higher risk for developing SBP. In general, the presence of 
      the MCP1 polymorphic G allele (AG/GG genotype) reduced the likelihood of survival 
      among patients with cirrhosis. RELEVANCE FOR PATIENTS: This study identifies a 
      critical subgroup of patients with SBP and also predicts prognosis in these 
      individuals. The presence of this genetic polymorphism in addition to the 
      underlying clinical condition may prompt aggressive monitoring, treatment, and 
      follow-up.
CI  - Copyright: (c) Whioce Publishing Pte. Ltd.
FAU - Murthy, K Vamsi
AU  - Murthy KV
AD  - Department of Gastroenterology, PSG Hospitals, Coimbatore, Tamil Nadu, India.
FAU - Subrahmanian, Meenu
AU  - Subrahmanian M
AD  - PSG Center for Molecular Medicine and Therapeutics, PSG Institute of Medical 
      Sciences and Research, Coimbatore, Tamil Nadu, India.
FAU - Sairam, Thiagarajan
AU  - Sairam T
AD  - PSG Center for Molecular Medicine and Therapeutics, PSG Institute of Medical 
      Sciences and Research, Coimbatore, Tamil Nadu, India.
AD  - Academic Research Consultant (Molecular Biology), Coimbatore, Tamil Nadu, India.
FAU - Leelakrishnan, Venkatakrishnan
AU  - Leelakrishnan V
AD  - Department of Gastroenterology, PSG Hospitals, Coimbatore, Tamil Nadu, India.
FAU - Sankaran, Ramalingam
AU  - Sankaran R
AD  - PSG Center for Molecular Medicine and Therapeutics, PSG Institute of Medical 
      Sciences and Research, Coimbatore, Tamil Nadu, India.
LA  - eng
PT  - Journal Article
DEP - 20210527
PL  - Singapore
TA  - J Clin Transl Res
JT  - Journal of clinical and translational research
JID - 101667205
PMC - PMC8259610
OTO - NOTNLM
OT  - ascites
OT  - liver cirrhosis
OT  - monocyte chemotactic protein 1
OT  - polymorphism
OT  - spontaneous bacterial peritonitis
COIS- No competing interest to declare.
EDAT- 2021/07/10 06:00
MHDA- 2021/07/10 06:01
PMCR- 2021/05/27
CRDT- 2021/07/09 07:02
PHST- 2020/12/07 00:00 [received]
PHST- 2021/03/25 00:00 [revised]
PHST- 2021/04/28 00:00 [accepted]
PHST- 2021/07/09 07:02 [entrez]
PHST- 2021/07/10 06:00 [pubmed]
PHST- 2021/07/10 06:01 [medline]
PHST- 2021/05/27 00:00 [pmc-release]
AID - jctres.07.202103.006 [pii]
PST - epublish
SO  - J Clin Transl Res. 2021 May 27;7(3):320-325. eCollection 2021 Jun 26.