PMID- 34240315 OWN - NLM STAT- MEDLINE DCOM- 20220125 LR - 20231213 IS - 1880-4233 (Electronic) IS - 1340-6868 (Linking) VI - 28 IP - 6 DP - 2021 Nov TI - CD1a- and CD83-positive dendritic cells as prognostic markers of metastasis development in early breast cancer patients. PG - 1328-1339 LID - 10.1007/s12282-021-01270-9 [doi] AB - PURPOSE: Dendritic cells (DCs) are the most potent antigen-presenting cells that play a major role in initiating the antitumor immune response in different types of cancer. However, the prognostic significance of the accumulation of these cells in human early breast tumors is not totally clear. The aim of this study is to evaluate the prognostic relevance of CD1a( +) and CD83( +) dendritic cells in early breast cancer patients. METHODS: We conducted immunohistochemical assays to determine the number of stromal CD1a( +) and CD83( +) DCs in primary tumors from early invasive ductal breast cancer patients, and analyzed their association with clinico-pathological characteristics. RESULTS: Patients with high CD1a( +) DC number had lower risk of bone metastatic occurrence, as well as, longer disease-free survival (DFS), bone metastasis-free survival (BMFS) and overall survival (OS). Moreover, CD1a( +) DC number was an independent prognostic factor for BMFS and OS. In contrast, we found that patients with high number of CD83( +) DCs had lower risk of mix (bone and visceral)-metastatic occurrence. Likewise, these patients presented better prognosis with longer DFS, mix-MFS and OS. Furthermore, CD83( +) DC number was an independent prognostic factor for DFS and OS. CONCLUSION: The quantification of the stromal infiltration of DCs expressing CD1a or CD83 in early invasive breast cancer patients serves to indicate the prognostic risk of developing metastasis in a specific site. CI - (c) 2021. The Japanese Breast Cancer Society. FAU - Giorello, Maria Belen AU - Giorello MB AD - Laboratorio de Inmunohematologia (IBYME) - Consejo Nacional de Investigaciones Cientificas Y Tecnicas (CONICET), Instituto de Biologia Y Medicina Experimental, Vuelta de Obligado 2490, Ciudad Autonoma de Buenos Aires, CP 1428, Buenos Aires, Argentina. FAU - Matas, Ayelen AU - Matas A AD - Laboratorio de Inmunohematologia (IBYME) - Consejo Nacional de Investigaciones Cientificas Y Tecnicas (CONICET), Instituto de Biologia Y Medicina Experimental, Vuelta de Obligado 2490, Ciudad Autonoma de Buenos Aires, CP 1428, Buenos Aires, Argentina. FAU - Marenco, Pablo AU - Marenco P AD - Departamento de Anatomia Patologica, Hospital Italiano, Juan Domingo Peron 4190, Ciudad Autonoma de Buenos Aires, CP 1181, Buenos Aires, Argentina. FAU - Davies, Kevin Mauro AU - Davies KM AD - Departamento de Anatomia Patologica, Hospital Italiano, Juan Domingo Peron 4190, Ciudad Autonoma de Buenos Aires, CP 1181, Buenos Aires, Argentina. FAU - Borzone, Francisco Raul AU - Borzone FR AD - Laboratorio de Inmunohematologia (IBYME) - Consejo Nacional de Investigaciones Cientificas Y Tecnicas (CONICET), Instituto de Biologia Y Medicina Experimental, Vuelta de Obligado 2490, Ciudad Autonoma de Buenos Aires, CP 1428, Buenos Aires, Argentina. FAU - Calcagno, Maria de Lujan AU - Calcagno ML AD - Facultad de Farmacia Y Bioquimica, Universidad de Buenos Aires, Junin 954, Ciudad Autonoma de Buenos Aires, CP 1113, Buenos Aires, Argentina. FAU - Garcia-Rivello, Hernan AU - Garcia-Rivello H AD - Departamento de Anatomia Patologica, Hospital Italiano, Juan Domingo Peron 4190, Ciudad Autonoma de Buenos Aires, CP 1181, Buenos Aires, Argentina. FAU - Wernicke, Alejandra AU - Wernicke A AD - Departamento de Anatomia Patologica, Hospital Italiano, Juan Domingo Peron 4190, Ciudad Autonoma de Buenos Aires, CP 1181, Buenos Aires, Argentina. FAU - Martinez, Leandro Marcelo AU - Martinez LM AD - Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA. FAU - Labovsky, Vivian AU - Labovsky V AD - Laboratorio de Inmunohematologia (IBYME) - Consejo Nacional de Investigaciones Cientificas Y Tecnicas (CONICET), Instituto de Biologia Y Medicina Experimental, Vuelta de Obligado 2490, Ciudad Autonoma de Buenos Aires, CP 1428, Buenos Aires, Argentina. 16vivian@gmail.com. FAU - Chasseing, Norma Alejandra AU - Chasseing NA AUID- ORCID: 0000-0001-7255-1926 AD - Laboratorio de Inmunohematologia (IBYME) - Consejo Nacional de Investigaciones Cientificas Y Tecnicas (CONICET), Instituto de Biologia Y Medicina Experimental, Vuelta de Obligado 2490, Ciudad Autonoma de Buenos Aires, CP 1428, Buenos Aires, Argentina. achasseing@ibyme.conicet.gov.ar. LA - eng PT - Journal Article DEP - 20210709 PL - Japan TA - Breast Cancer JT - Breast cancer (Tokyo, Japan) JID - 100888201 RN - 0 (Antigens, CD) RN - 0 (Antigens, CD1) RN - 0 (Biomarkers, Tumor) RN - 0 (Immunoglobulins) RN - 0 (Membrane Glycoproteins) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Antigens, CD/*analysis/immunology MH - Antigens, CD1/*analysis/immunology MH - Biomarkers, Tumor/immunology MH - Breast Neoplasms/*pathology MH - Dendritic Cells/immunology/pathology MH - Female MH - Humans MH - Immunoglobulins/*analysis/immunology MH - Membrane Glycoproteins/*analysis/immunology MH - Middle Aged MH - Retrospective Studies MH - Survival Analysis MH - CD83 Antigen OTO - NOTNLM OT - Biomarkers OT - Breast cancer OT - CD1a dendritic cells OT - CD83 dendritic cells OT - Metastasis EDAT- 2021/07/10 06:00 MHDA- 2022/01/27 06:00 CRDT- 2021/07/09 07:12 PHST- 2021/02/08 00:00 [received] PHST- 2021/06/27 00:00 [accepted] PHST- 2021/07/10 06:00 [pubmed] PHST- 2022/01/27 06:00 [medline] PHST- 2021/07/09 07:12 [entrez] AID - 10.1007/s12282-021-01270-9 [pii] AID - 10.1007/s12282-021-01270-9 [doi] PST - ppublish SO - Breast Cancer. 2021 Nov;28(6):1328-1339. doi: 10.1007/s12282-021-01270-9. Epub 2021 Jul 9.