PMID- 34240468
OWN - NLM
STAT- MEDLINE
DCOM- 20220411
LR  - 20220411
IS  - 1365-2125 (Electronic)
IS  - 0306-5251 (Linking)
VI  - 88
IP  - 2
DP  - 2022 Feb
TI  - Clinical and echocardiographic characteristics after six months of 
      sacubitril/valsartan in Chagas heart disease - A case series.
PG  - 429-436
LID - 10.1111/bcp.14978 [doi]
AB  - Chagas cardiomyopathy is the most prevalent non-ischaemic cardiomyopathy in Latin 
      America, with high morbidity and mortality even today. Treatment of these 
      patients is based on the use of medications for heart failure. This study 
      evaluated a case series of patients with Chagas heart disease who used 
      sacubitril/valsartan at a referral hospital for this disease in Brazil. After 
      6 months, there was a symptomatic improvement in these individuals assessed by 
      the New York Heart Association (NYHA) functional class, with a 44.3% reduction in 
      the absolute number of patients classified as III-IV in the period (P = 0.035), 
      but without changes in the parameters on the echocardiogram for reverse 
      ventricular remodelling. There was a high mortality rate and number of 
      hospitalizations. These results emphasize the importance of studying the use of 
      sacubitril/valsartan in Chagas heart disease to better describe its effectiveness 
      considering the particularities of these individuals.
CI  - (c) 2021 British Pharmacological Society.
FAU - Figueiredo, Clara Salles
AU  - Figueiredo CS
AUID- ORCID: 0000-0002-7722-9087
AD  - Federal University of Bahia, Rua Augusto Viana, s/n, Salvador, Bahia, 40110-909, 
      Brazil.
FAU - de Melo, Rodrigo Morel Vieira
AU  - de Melo RMV
AD  - Federal University of Bahia, Rua Augusto Viana, s/n, Salvador, Bahia, 40110-909, 
      Brazil.
FAU - Viana, Taina Teixeira
AU  - Viana TT
AD  - Federal University of Bahia, Rua Augusto Viana, s/n, Salvador, Bahia, 40110-909, 
      Brazil.
FAU - de Jesus, Aline Grimaldi Queiroz
AU  - de Jesus AGQ
AD  - Ana Nery Hospital, R. Saldanha Marinho, s/n - Caixa D'agua, Salvador, Bahia, 
      40301-155, Brazil.
FAU - da Silva, Tainara Cerqueira
AU  - da Silva TC
AD  - Ana Nery Hospital, R. Saldanha Marinho, s/n - Caixa D'agua, Salvador, Bahia, 
      40301-155, Brazil.
FAU - da Silva, Vitor Mamedio
AU  - da Silva VM
AD  - Ana Nery Hospital, R. Saldanha Marinho, s/n - Caixa D'agua, Salvador, Bahia, 
      40301-155, Brazil.
FAU - de Carvalho, William Neves
AU  - de Carvalho WN
AD  - Federal University of Bahia, Rua Augusto Viana, s/n, Salvador, Bahia, 40110-909, 
      Brazil.
FAU - da Silva, Daniela Nascimento Valame
AU  - da Silva DNV
AD  - Ana Nery Hospital, R. Saldanha Marinho, s/n - Caixa D'agua, Salvador, Bahia, 
      40301-155, Brazil.
FAU - Passos, Luiz Carlos Santana
AU  - Passos LCS
AD  - Federal University of Bahia, Rua Augusto Viana, s/n, Salvador, Bahia, 40110-909, 
      Brazil.
LA  - eng
PT  - Journal Article
DEP - 20210731
PL  - England
TA  - Br J Clin Pharmacol
JT  - British journal of clinical pharmacology
JID - 7503323
RN  - 0 (Aminobutyrates)
RN  - 0 (Angiotensin Receptor Antagonists)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Drug Combinations)
RN  - 0 (Tetrazoles)
RN  - 17ERJ0MKGI (sacubitril)
RN  - 80M03YXJ7I (Valsartan)
SB  - IM
MH  - Aminobutyrates/therapeutic use
MH  - Angiotensin Receptor Antagonists/therapeutic use
MH  - Biphenyl Compounds/therapeutic use
MH  - Drug Combinations
MH  - Echocardiography
MH  - *Heart Failure/chemically induced/diagnostic imaging/drug therapy
MH  - Humans
MH  - Stroke Volume
MH  - *Tetrazoles/therapeutic use
MH  - Treatment Outcome
MH  - Valsartan
OTO - NOTNLM
OT  - Chagas cardiomyopathy
OT  - Chagas disease
OT  - heart failure
OT  - sacubitril/valsartan
EDAT- 2021/07/10 06:00
MHDA- 2022/04/12 06:00
CRDT- 2021/07/09 07:19
PHST- 2021/06/29 00:00 [revised]
PHST- 2021/04/20 00:00 [received]
PHST- 2021/06/30 00:00 [accepted]
PHST- 2021/07/10 06:00 [pubmed]
PHST- 2022/04/12 06:00 [medline]
PHST- 2021/07/09 07:19 [entrez]
AID - 10.1111/bcp.14978 [doi]
PST - ppublish
SO  - Br J Clin Pharmacol. 2022 Feb;88(2):429-436. doi: 10.1111/bcp.14978. Epub 2021 
      Jul 31.