PMID- 34243000
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 236
DP  - 2021 Jul
TI  - Comparison of lipid-normalised concentrations of persistent organic pollutants 
      (POPs) between serum and adipose tissue.
PG  - 113801
LID - S1438-4639(21)00116-4 [pii]
LID - 10.1016/j.ijheh.2021.113801 [doi]
AB  - Human biomonitoring of persistent organic pollutants (POPs) is typically based on 
      serum analysis and for comparison and modelling purposes, data are often 
      normalised to the lipid content of the serum. Such approach assumes a steady 
      state of the compound between the serum lipids and for example lipid-rich adipose 
      tissue. Few published data are available to assess the validity of this 
      assumption. The aim of this study was to measure concentrations of POPs in both 
      serum and adipose tissue samples from 32 volunteers and compare the 
      lipid-normalised concentrations between serum and adipose tissue. For p,p'-DDE, 
      PCB-138, PCB-153 and PCB-180, lipid-normalised adipose tissue concentrations were 
      positively correlated to the respective serum concentrations but generally were 
      more highly concentrated in adipose tissue. These results suggest that the 
      investigated legacy POPs that were consistently found in paired samples may often 
      not be in a steady state between the lipid compartments of the human body. 
      Consequently, the analysis of serum lipids as a surrogate for adipose tissue 
      exposure may more often than not underestimate total body burden of POPs. Further 
      research is warranted to confirm the findings of this study.
CI  - Copyright (c) 2021 Elsevier GmbH. All rights reserved.
FAU - Sontag, Nis-Julius
AU  - Sontag NJ
AD  - Queensland Alliance for Environmental Health Sciences, The University of 
      Queensland, Australia; Wesley Hospital Brisbane, Queensland, Australia. 
      Electronic address: n-j.sontag@web.de.
FAU - Banks, Andrew P W
AU  - Banks APW
AD  - Queensland Alliance for Environmental Health Sciences, The University of 
      Queensland, Australia.
FAU - Aylward, Lesa L
AU  - Aylward LL
AD  - Queensland Alliance for Environmental Health Sciences, The University of 
      Queensland, Australia; Summit Toxicology, LLP, Virginia, USA.
FAU - O'Rourke, Nicholas A
AU  - O'Rourke NA
AD  - Wesley Hospital Brisbane, Queensland, Australia; Faculty of Medicine, The 
      University of Queensland, Australia.
FAU - Cavallucci, David J
AU  - Cavallucci DJ
AD  - Wesley Hospital Brisbane, Queensland, Australia; Faculty of Medicine, The 
      University of Queensland, Australia.
FAU - Mueller, Jochen F
AU  - Mueller JF
AD  - Queensland Alliance for Environmental Health Sciences, The University of 
      Queensland, Australia.
FAU - Drage, Daniel S
AU  - Drage DS
AD  - Queensland Alliance for Environmental Health Sciences, The University of 
      Queensland, Australia; School of Geography, Earth and Environmental Sciences, 
      University of Birmingham, UK.
LA  - eng
PT  - Journal Article
DEP - 20210706
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Environmental Pollutants)
RN  - 0 (Lipids)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adipose Tissue
MH  - Dichlorodiphenyl Dichloroethylene
MH  - *Environmental Pollutants
MH  - Humans
MH  - Lipids
MH  - Persistent Organic Pollutants
MH  - *Polychlorinated Biphenyls
OTO - NOTNLM
OT  - Exposure
OT  - Human
OT  - Lipid compartments
OT  - Persistent organic pollutants
EDAT- 2021/07/10 06:00
MHDA- 2021/10/26 06:00
CRDT- 2021/07/09 20:27
PHST- 2021/05/11 00:00 [received]
PHST- 2021/06/28 00:00 [revised]
PHST- 2021/06/29 00:00 [accepted]
PHST- 2021/07/10 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/07/09 20:27 [entrez]
AID - S1438-4639(21)00116-4 [pii]
AID - 10.1016/j.ijheh.2021.113801 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2021 Jul;236:113801. doi: 10.1016/j.ijheh.2021.113801. 
      Epub 2021 Jul 6.