PMID- 34243022
OWN - NLM
STAT- MEDLINE
DCOM- 20210826
LR  - 20210826
IS  - 1873-2682 (Electronic)
IS  - 1011-1344 (Linking)
VI  - 221
DP  - 2021 Aug
TI  - Photocatalytic degradation of drugs in water mediated by acetylated riboflavin 
      and visible light: A mechanistic study.
PG  - 112250
LID - S1011-1344(21)00129-9 [pii]
LID - 10.1016/j.jphotobiol.2021.112250 [doi]
AB  - There is a current concern, among the scientific community, on the pollutants 
      classified as "persistent organic pollutants (POPs)". Pharmaceuticals and 
      personal care products (PPCPs) belong to this family of contaminants; therefore, 
      it is necessary to find more efficient techniques able to achieve their removal 
      from the environment. This study focuses on two different pharmaceuticals: 
      carbamazepine and atenolol, chosen for their widespread use and their different 
      chemical and medical properties. In this work, an organic dye, acetylated 
      riboflavin, has been used in combination with visible light to achieve the 
      photodegradation of these two POPs in <2 h. Moreover, photophysical experiments 
      demonstrated the involvement of the singlet and triplet excited states of 
      acetylated riboflavin and the generated singlet oxygen in the removal of these 
      drugs. Besides, a detailed UFLC-MS-MS analysis of the photoproducts confirmed the 
      oxidation of the drugs. Finally, a plausible mechanism has been postulated.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Pavanello, Alice
AU  - Pavanello A
AD  - Instituto de Tecnologia Quimica UPV-CSIC, Universitat Politecnica de Valencia, 
      E-46022 Valencia, Spain.
FAU - Fabbri, Debora
AU  - Fabbri D
AD  - Dipartimento di Chimica, Universita di Torino, via P. Giuria 5, 10125 Torino, 
      Italy.
FAU - Calza, Paola
AU  - Calza P
AD  - Dipartimento di Chimica, Universita di Torino, via P. Giuria 5, 10125 Torino, 
      Italy.
FAU - Battiston, Debora
AU  - Battiston D
AD  - Dipartimento di Chimica, Universita di Torino, via P. Giuria 5, 10125 Torino, 
      Italy.
FAU - Miranda, Miguel A
AU  - Miranda MA
AD  - Instituto de Tecnologia Quimica UPV-CSIC, Universitat Politecnica de Valencia, 
      E-46022 Valencia, Spain.
FAU - Marin, M Luisa
AU  - Marin ML
AD  - Instituto de Tecnologia Quimica UPV-CSIC, Universitat Politecnica de Valencia, 
      E-46022 Valencia, Spain. Electronic address: marmarin@qim.upv.es.
LA  - eng
PT  - Journal Article
DEP - 20210629
PL  - Switzerland
TA  - J Photochem Photobiol B
JT  - Journal of photochemistry and photobiology. B, Biology
JID - 8804966
RN  - 0 (Water Pollutants, Chemical)
RN  - 17778-80-2 (Singlet Oxygen)
RN  - 33CM23913M (Carbamazepine)
RN  - 50VV3VW0TI (Atenolol)
RN  - TLM2976OFR (Riboflavin)
SB  - IM
MH  - Acetylation
MH  - Atenolol/chemistry
MH  - Carbamazepine/*chemistry
MH  - Catalysis
MH  - Kinetics
MH  - *Light
MH  - Photolysis/drug effects/*radiation effects
MH  - Riboflavin/*chemistry
MH  - Singlet Oxygen/chemistry
MH  - Water Pollutants, Chemical/*chemistry/metabolism
OTO - NOTNLM
OT  - Electron transfer
OT  - Organic dye
OT  - Photodegradation products
OT  - Singlet oxygen
OT  - Visible light
EDAT- 2021/07/10 06:00
MHDA- 2021/08/27 06:00
CRDT- 2021/07/09 20:28
PHST- 2021/02/13 00:00 [received]
PHST- 2021/06/02 00:00 [revised]
PHST- 2021/06/26 00:00 [accepted]
PHST- 2021/07/10 06:00 [pubmed]
PHST- 2021/08/27 06:00 [medline]
PHST- 2021/07/09 20:28 [entrez]
AID - S1011-1344(21)00129-9 [pii]
AID - 10.1016/j.jphotobiol.2021.112250 [doi]
PST - ppublish
SO  - J Photochem Photobiol B. 2021 Aug;221:112250. doi: 
      10.1016/j.jphotobiol.2021.112250. Epub 2021 Jun 29.