PMID- 34245591
OWN - NLM
STAT- MEDLINE
DCOM- 20220104
LR  - 20231107
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 77
IP  - 1
DP  - 2022 Jan
TI  - A bird's eye view on the role of dendritic cells in SARS-CoV-2 infection: 
      Perspectives for immune-based vaccines.
PG  - 100-110
LID - 10.1111/all.15004 [doi]
AB  - Coronavirus disease-19 (COVID-19) is a complex disorder caused by the pandemic 
      diffusion of a novel coronavirus named SARS-CoV-2. Clinical manifestations vary 
      from silent infection to severe pneumonia, disseminated thrombosis, multi-organ 
      failure, and death. COVID-19 pathogenesis is still not fully elucidated, while 
      increasing evidence suggests that disease phenotypes are strongly related to the 
      virus-induced immune system's dysregulation. Indeed, when the virus-host cross 
      talk is out of control, the occurrence of an aberrant systemic inflammatory 
      reaction, named "cytokine storm," leads to a detrimental impairment of the 
      adaptive immune response. Dendritic cells (DCs) are the most potent 
      antigen-presenting cells able to support innate immune and promote adaptive 
      responses. Besides, DCs play a key role in the anti-viral defense. The aim of 
      this review is to focus on DC involvement in SARS-CoV-2 infection to better 
      understand pathogenesis and clinical behavior of COVID-19 and explore potential 
      implications for immune-based therapy strategies.
CI  - (c) 2021 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
FAU - Galati, Domenico
AU  - Galati D
AUID- ORCID: 0000-0001-5613-9149
AD  - Hematology-Oncology and Stem Cell Transplantation Unit, Department of Hematology 
      and Developmental Therapeutics, Istituto Nazionale Tumori- IRCCS- Fondazione G. 
      Pascale, Napoli, Italy.
FAU - Zanotta, Serena
AU  - Zanotta S
AD  - Hematology-Oncology and Stem Cell Transplantation Unit, Department of Hematology 
      and Developmental Therapeutics, Istituto Nazionale Tumori- IRCCS- Fondazione G. 
      Pascale, Napoli, Italy.
FAU - Capitelli, Ludovica
AU  - Capitelli L
AD  - Department of Clinical Medicine and Surgery, Universita degli Studi di Napoli 
      Federico II, Napoli, Italy.
FAU - Bocchino, Marialuisa
AU  - Bocchino M
AD  - Department of Clinical Medicine and Surgery, Universita degli Studi di Napoli 
      Federico II, Napoli, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210724
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Vaccines)
SB  - IM
MH  - *COVID-19
MH  - Dendritic Cells
MH  - Humans
MH  - Pandemics
MH  - SARS-CoV-2
MH  - *Vaccines
PMC - PMC8441836
OTO - NOTNLM
OT  - COVID-19
OT  - SARS-CoV-2
OT  - dendritic cells
OT  - immune-therapies
OT  - vaccines
COIS- All authors declare that they have no conflict of interest.
EDAT- 2021/07/11 06:00
MHDA- 2022/01/05 06:00
PMCR- 2021/07/24
CRDT- 2021/07/10 17:06
PHST- 2021/04/26 00:00 [received]
PHST- 2021/07/05 00:00 [accepted]
PHST- 2021/07/11 06:00 [pubmed]
PHST- 2022/01/05 06:00 [medline]
PHST- 2021/07/10 17:06 [entrez]
PHST- 2021/07/24 00:00 [pmc-release]
AID - ALL15004 [pii]
AID - 10.1111/all.15004 [doi]
PST - ppublish
SO  - Allergy. 2022 Jan;77(1):100-110. doi: 10.1111/all.15004. Epub 2021 Jul 24.