PMID- 34245761
OWN - NLM
STAT- MEDLINE
DCOM- 20220214
LR  - 20220214
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 413
DP  - 2021 Sep 10
TI  - Exercise prevents the impairment of learning and memory in prenatally 
      phthalate-exposed male rats by improving the expression of plasticity-related 
      proteins.
PG  - 113444
LID - S0166-4328(21)00332-6 [pii]
LID - 10.1016/j.bbr.2021.113444 [doi]
AB  - Regular exercise has been identified to facilitate neuroplasticity that maximize 
      functional outcome after brain injuries. Brain-derived neurotrophic factor (BDNF) 
      has emerged as a key facilitator of neuroplasticity after exercise. The 
      activity-regulated cytoskeleton associated protein (Arc) is induced by BDNF and 
      N-methyl-d-aspartic acid receptor (NMDAR), contributing to functional 
      modification of neuroplasticity in the hippocampus. Meanwhile, early-life 
      exposure to neuroendocrine disruptor di-(2-ethylhexyl)-phthalate (DEHP) is a risk 
      factor for behavioral deficits, but the mechanisms responsible for DEHP-induced 
      neurotoxicity are not well understood. The purpose of this study is to 
      investigate whether hippocampal Arc expression is impaired by DEHP exposure and 
      to examine the protective role of exercise in the prenatally DEHP-exposed male 
      rats. Sprague Dawley dams were fed with vehicle or DEHP during gestation. The 
      male offspring were trained to treadmill running for 5 weeks followed by 
      examination of behavioral and biochemical outcomes. The results showed that 
      DEHP-exposed rats exhibited impairment of spatial learning and memory as well as 
      down-regulations of BDNF, NMDAR, Arc, and synaptophysin. Importantly, aerobic 
      exercise during childhood-adolescence prevented the impairment of learning and 
      memory by recovering the expressions of BDNF, NMDAR, Arc, and synaptophysin. 
      These findings suggest that exercise may provide beneficial effects on 
      ameliorating the impairment of neuroplasticity in the prenatally DEHP-exposed 
      male rats at late adolescence.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Sun, Gwo-Ching
AU  - Sun GC
AD  - Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung, 
      Taiwan; Department of Anesthesiology, School of Medicine, College of Medicine, 
      Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: 
      gcsun39@kmu.edu.tw.
FAU - Lee, Yi-Ju
AU  - Lee YJ
AD  - Department of Sports Medicine, College of Medicine, Kaohsiung Medical University, 
      Kaohsiung, Taiwan. Electronic address: lyr092124@gmail.com.
FAU - Lee, Yi-Ching
AU  - Lee YC
AD  - Department of Food and Beverage Services, Tainan University of Technology, 
      Tainan, Taiwan. Electronic address: t10045@mail.tut.edu.tw.
FAU - Yu, Hsien-Fu
AU  - Yu HF
AD  - Department of Sports Medicine, College of Medicine, Kaohsiung Medical University, 
      Kaohsiung, Taiwan. Electronic address: sjm71518056@gmail.com.
FAU - Wang, Dean-Chuan
AU  - Wang DC
AD  - Department of Sports Medicine, College of Medicine, Kaohsiung Medical University, 
      Kaohsiung, Taiwan; Department of Physiology, College of Medicine, Kaohsiung 
      Medical University, Kaohsiung, Taiwan. Electronic address: dcw@kmu.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210707
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Phthalic Acids)
RN  - 6O7F7IX66E (phthalic acid)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Cognitive Dysfunction/*chemically induced/metabolism/physiopathology/*prevention 
      & control
MH  - Endocrine Disruptors/*adverse effects
MH  - Female
MH  - Male
MH  - Neuronal Plasticity/*physiology
MH  - Phthalic Acids/*adverse effects
MH  - Physical Conditioning, Animal/*physiology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically 
      induced/metabolism/physiopathology/*prevention & control
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spatial Learning/physiology
MH  - Spatial Memory/physiology
OTO - NOTNLM
OT  - Activity-regulated cytoskeleton associated protein
OT  - Brain-derived neurotrophic factor
OT  - Di-(2-ethylhexyl)-phthalate
OT  - Exercise
OT  - N-methyl-d-aspartic acid receptor
EDAT- 2021/07/11 06:00
MHDA- 2022/02/15 06:00
CRDT- 2021/07/10 20:08
PHST- 2021/03/08 00:00 [received]
PHST- 2021/06/27 00:00 [revised]
PHST- 2021/06/30 00:00 [accepted]
PHST- 2021/07/11 06:00 [pubmed]
PHST- 2022/02/15 06:00 [medline]
PHST- 2021/07/10 20:08 [entrez]
AID - S0166-4328(21)00332-6 [pii]
AID - 10.1016/j.bbr.2021.113444 [doi]
PST - ppublish
SO  - Behav Brain Res. 2021 Sep 10;413:113444. doi: 10.1016/j.bbr.2021.113444. Epub 
      2021 Jul 7.