PMID- 34245931
OWN - NLM
STAT- MEDLINE
DCOM- 20210809
LR  - 20230912
IS  - 1873-2763 (Electronic)
IS  - 8756-3282 (Print)
IS  - 1873-2763 (Linking)
VI  - 152
DP  - 2021 Nov
TI  - Survival in primary hyperparathyroidism over five decades (1965-2010) a 
      population-based retrospective study.
PG  - 116099
LID - S8756-3282(21)00264-7 [pii]
LID - 10.1016/j.bone.2021.116099 [doi]
AB  - CONTEXT: Survival in patients with primary hyperparathyroidism (PHPT) remains 
      uncertain. OBJECTIVE: To update survival in patients with PHPT in a United States 
      community population. DESIGN: Retrospective cohort study. SETTING: Community 
      population in Rochester, Minnesota. PARTICIPANTS: Residents who met criteria for 
      PHPT from 1965 to 2010. INTERVENTIONS: Survival was estimated using the Kaplan 
      Meier product-limit method. The Cox proportional hazards model was used to 
      determine associations, as relative hazards (RR) with 95% confidence intervals 
      (CI), of various risk factors with time to death. MAIN OUTCOME MEASURE: The 
      overall age and gender-adjusted survival compared to white Minnesota residents. 
      RESULTS: We identified 1139 PHPT individuals, 76% female, with a median age of 
      58 years. Most were observed without parathyroidectomy (69%). The relative risk 
      of death among the entire cohort was 0.996 (95% CI: 0.91-1.09, P = 0.935) which 
      was not different compared to Minnesota residents. Those with maximum serum 
      calcium level >/= 10.8 mg/dL (0.7 mg/dL above the reference range) had an increase 
      in mortality (RR 1.32, 95% CI: 1.10-1.58, P = 0.002). Survival among all PHPT 
      individuals after parathyroidectomy was no different from expected (RR = 1.06, 
      95% CI 0.89-1.28; P = 0.508). Mortality was significantly decreased after 
      parathyroidectomy in those with serum calcium levels >/=10.8 mg/dL (HR 0.47, 95% 
      CI: 0.36-0.61, P < 0.001). CONCLUSIONS: Mortality in the entire cohort was not 
      different from expected. PHPT patients with a maximum serum calcium 
      level >/= 10.8 mg/dL had increased mortality. Survival was improved after 
      parathyroidectomy in those with this degree of hypercalcemia.
CI  - Copyright (c) 2021. Published by Elsevier Inc.
FAU - Wermers, Robert A
AU  - Wermers RA
AD  - Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, 
      Rochester, MN, USA; Department of Medicine, Mayo Clinic, Rochester, MN, USA.
FAU - Griebeler, Marcio L
AU  - Griebeler ML
AD  - Cleveland Clinic, Cleveland, OH, USA.
FAU - Thapa, Prabin
AU  - Thapa P
AD  - Divisions of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, 
      USA; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
FAU - Hathcock, Matthew A
AU  - Hathcock MA
AD  - Divisions of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, 
      USA; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
FAU - Kearns, Ann E
AU  - Kearns AE
AD  - Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, 
      Rochester, MN, USA; Department of Medicine, Mayo Clinic, Rochester, MN, USA. 
      Electronic address: kearns.ann@mayo.edu.
LA  - eng
GR  - R01 AG034676/AG/NIA NIH HHS/United States
GR  - R33 AG058738/AG/NIA NIH HHS/United States
GR  - UL1 TR000135/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20210708
PL  - United States
TA  - Bone
JT  - Bone
JID - 8504048
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Calcium
MH  - Female
MH  - Humans
MH  - *Hypercalcemia
MH  - *Hyperparathyroidism, Primary/surgery
MH  - Male
MH  - Middle Aged
MH  - Parathyroidectomy
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC10495014
MID - NIHMS1926508
OTO - NOTNLM
OT  - Epidemiology
OT  - Hypercalcemia
OT  - Hyperparathyroidism
OT  - Mortality
OT  - Parathyroidectomy
COIS- Declaration of competing interest All authors state that they have no conflicts 
      of interest.
EDAT- 2021/07/11 06:00
MHDA- 2021/08/10 06:00
PMCR- 2023/09/11
CRDT- 2021/07/10 20:11
PHST- 2020/11/16 00:00 [received]
PHST- 2021/06/10 00:00 [revised]
PHST- 2021/07/04 00:00 [accepted]
PHST- 2021/07/11 06:00 [pubmed]
PHST- 2021/08/10 06:00 [medline]
PHST- 2021/07/10 20:11 [entrez]
PHST- 2023/09/11 00:00 [pmc-release]
AID - S8756-3282(21)00264-7 [pii]
AID - 10.1016/j.bone.2021.116099 [doi]
PST - ppublish
SO  - Bone. 2021 Nov;152:116099. doi: 10.1016/j.bone.2021.116099. Epub 2021 Jul 8.