PMID- 34245984
OWN - NLM
STAT- MEDLINE
DCOM- 20210929
LR  - 20210929
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 288
DP  - 2021 Nov 1
TI  - Associations of exposure to multiple trace elements with the risk of goiter: A 
      case-control study.
PG  - 117739
LID - S0269-7491(21)01321-X [pii]
LID - 10.1016/j.envpol.2021.117739 [doi]
AB  - Goiter is one of common endocrine diseases, and its etiology has not been fully 
      elucidated. The changes in trace elements' levels have an important impact on the 
      thyroid. We designed a case-control study, which involved 383 goiter cases and 
      383 matched controls. We measured these elements in the urine of participants by 
      inductively coupled plasma optical emission spectrometry (ICP-OES), graphite 
      furnace atomic absorption spectrometry (GFAAS) and As(3+)-Ce(4+) catalytic 
      spectrophotometry. Least Absolute Shrinkage and Selection Operator (LASSO) 
      regression was used to select the elements into multi-element models, conditional 
      logistic regression models were applied to analyze the association between 
      elements and goiter risk. Bayesian kernel machine regression (BKMR) model was 
      used to depict elements' mixtures and evaluate their joint effects. Finally, 7 
      elements were included in the multi-element model. We found that the 
      concentrations of lithium (Li), strontium (Sr) and barium (Ba) had a negative 
      effect with goiter risk, and lead (Pb) and iodine (I) showed an extreme positive 
      effect. Additionally, compared with the lowest levels, patients with highest 
      quartiles of I and Pb were 6.49 and 1.94 times more likely to have goiter, 
      respectively. On the contrary, in its second and third quartiles, arsenic (As) 
      showed a negative effect (both OR<1). BKMR model showed a certain interaction 
      among Pb, As, Sr and Li on goiter risk. Further large sample studies are needed 
      to confirm these findings in the future.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - He, Jia-Liu
AU  - He JL
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
FAU - Li, Guo-Ao
AU  - Li GA
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
FAU - Zhu, Zhen-Yu
AU  - Zhu ZY
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
FAU - Hu, Ming-Jun
AU  - Hu MJ
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
FAU - Wu, Hua-Bing
AU  - Wu HB
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
FAU - Zhu, Jin-Liang
AU  - Zhu JL
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
FAU - Zhao, Huan-Huan
AU  - Zhao HH
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
FAU - Zhang, Han-Shuang
AU  - Zhang HS
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
FAU - Huang, Fen
AU  - Huang F
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. Electronic 
      address: fenh@ahmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210706
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Trace Elements)
SB  - IM
MH  - Bayes Theorem
MH  - Case-Control Studies
MH  - *Goiter/epidemiology
MH  - Humans
MH  - Spectrophotometry, Atomic
MH  - *Trace Elements/analysis
OTO - NOTNLM
OT  - Goiter
OT  - Risk factors
OT  - Trace elements
EDAT- 2021/07/11 06:00
MHDA- 2021/09/30 06:00
CRDT- 2021/07/10 20:14
PHST- 2021/04/17 00:00 [received]
PHST- 2021/06/16 00:00 [revised]
PHST- 2021/07/04 00:00 [accepted]
PHST- 2021/07/11 06:00 [pubmed]
PHST- 2021/09/30 06:00 [medline]
PHST- 2021/07/10 20:14 [entrez]
AID - S0269-7491(21)01321-X [pii]
AID - 10.1016/j.envpol.2021.117739 [doi]
PST - ppublish
SO  - Environ Pollut. 2021 Nov 1;288:117739. doi: 10.1016/j.envpol.2021.117739. Epub 
      2021 Jul 6.