PMID- 34246981
OWN - NLM
STAT- MEDLINE
DCOM- 20211222
LR  - 20211222
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 358
DP  - 2021 Sep 15
TI  - Genetic basis of Guillain-Barre syndrome.
PG  - 577651
LID - S0165-5728(21)00178-8 [pii]
LID - 10.1016/j.jneuroim.2021.577651 [doi]
AB  - Guillain-Barre syndrome (GBS) is an autoimmune disease in which the peripheral 
      nerves are affected. GBS has different subtypes, such as acute inflammatory 
      demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). 
      Infections, e.g. Campylobacter jejuni, influenza, etc., can lead to GBS. Both 
      environmental and genetic factors play a major role in the occurrence of GBS. 
      Several studies have investigated the genetic basis of GBS. Human leukocyte 
      antigens (HLA) genes, Cluster of Differentiation (CD) 1A, FAS, Fc gamma receptors 
      (FcGR), Intercellular adhesion molecule-1 (ICAM1), different interleukins, 
      Nucleotide oligomerization domain (NOD), Toll-like receptor 4 (TLR4), Tumor 
      necrosis factor-alpha (TNF-alpha) are among the genes reported to be involved in 
      susceptibility to the disease. Dysregulation and dysfunction of the mentioned 
      gene products, even though their role in the pathogenesis of GBS is 
      controversial, play a role in inflammatory pathways, regulation of immune cells 
      and system, antigen presentation, axonal degeneration, apoptosis, and 
      cross-reaction. This review aims to summarize associated genes with GBS to 
      contribute to better understanding of GBS pathogenesis and discover the gene 
      pathways that play role in GBS occurrence.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Khanmohammadi, Shaghayegh
AU  - Khanmohammadi S
AD  - Research Center for Immunodeficiencies, Children's Medical Center, Tehran 
      University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, 
      Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research 
      Network (USERN), Tehran, Iran.
FAU - Malekpour, Mahdi
AU  - Malekpour M
AD  - Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal 
      Scientific Education and Research Network (USERN), Tehran, Iran; Student Research 
      Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Jabbari, Parnian
AU  - Jabbari P
AD  - Research Center for Immunodeficiencies, Children's Medical Center, Tehran 
      University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, 
      Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research 
      Network (USERN), Tehran, Iran.
FAU - Rezaei, Nima
AU  - Rezaei N
AD  - Research Center for Immunodeficiencies, Children's Medical Center, Tehran 
      University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, 
      Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research 
      Network (USERN), Tehran, Iran; Department of Immunology, School of Medicine, 
      Tehran University of Medical Sciences, Tehran, Iran. Electronic address: 
      rezaei_nima@tums.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210701
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - *Gene-Environment Interaction
MH  - Genetic Predisposition to Disease/*genetics
MH  - Guillain-Barre Syndrome/*genetics/*immunology
MH  - Humans
MH  - Inflammation Mediators/*immunology
MH  - Peripheral Nerves/immunology
OTO - NOTNLM
OT  - Genetics
OT  - Guillain-Barre syndrome
OT  - Immunology
OT  - Pathogenesis
EDAT- 2021/07/12 06:00
MHDA- 2021/12/24 06:00
CRDT- 2021/07/11 20:48
PHST- 2021/02/28 00:00 [received]
PHST- 2021/06/05 00:00 [revised]
PHST- 2021/06/27 00:00 [accepted]
PHST- 2021/07/12 06:00 [pubmed]
PHST- 2021/12/24 06:00 [medline]
PHST- 2021/07/11 20:48 [entrez]
AID - S0165-5728(21)00178-8 [pii]
AID - 10.1016/j.jneuroim.2021.577651 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2021 Sep 15;358:577651. doi: 10.1016/j.jneuroim.2021.577651. Epub 
      2021 Jul 1.