PMID- 34249422
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210713
IS  - 2156-6976 (Print)
IS  - 2156-6976 (Electronic)
IS  - 2156-6976 (Linking)
VI  - 11
IP  - 6
DP  - 2021
TI  - IL-17 signaling pathway plays a key role in laryngeal squamous cell carcinoma 
      with ethnic specificity.
PG  - 2684-2695
AB  - Laryngeal squamous cell carcinoma (LSCC) is a common aggressive head and neck 
      squamous cell carcinoma (HNSCC) and racial disparities have been reported to 
      exist in it. However, its molecular mechanism and associated ethnic specificity 
      are still unclear. Here, we leveraged mRNA expression data from 2 gene expression 
      omnibus datasets (GSE142083 & GSE117005) of Chinese samples and the cancer genome 
      atlas (TCGA) datasets of Caucasian samples to demonstrate the expression 
      signature of LSCC. The GSE142083 dataset was used as the discovery set since it 
      had 53 pairs of LSCC tissues and matched adjacent normal tissues, and the 
      GSE117005 dataset was treated as the validation set with 5 pairs of tissues. 
      Differential gene expression analysis and enrichment pathway analysis were 
      performed. Besides, we employed weighted gene co-expression network analysis to 
      identify hub genes in validated pathways. The TCGA datasets were used to evaluate 
      ethnic specificity. Immunohistochemistry (IHC) was employed to further validate 
      the hub gene. Overall, the IL-17 signaling pathway was significantly enriched for 
      upregulated genes in two Chinese datasets while not in TCGA datasets; and IL17RC, 
      MAPK3, S100A8, MMP3, CXCL8, and TNFA1P3 were hub genes regulating such pathway. 
      Therein, IL17RC might be the most important one and the IHC results displayed 
      that the IL17RC gene upregulated in the LSCC tissue. IL-17 signaling pathway has 
      an ethnicity-specific effect in LSCC where it is upregulated in the Chinese while 
      not in the Caucasians and IL17RC might play a key role. Targeting genes located 
      in the IL-17 signaling pathway may be beneficial for Chinese LSCC patients.
CI  - AJCR Copyright (c) 2021.
FAU - Qi, Li
AU  - Qi L
AD  - Department of Otorhinolaryngology, The First Hospital of China Medical University 
      Shenyang 110001, Liaoning Province, China.
FAU - Bao, Wenzhao
AU  - Bao W
AD  - Department of Anesthesiology, Affiliated Hospital of Inner Mongolia University 
      for The Nationalities Inner Mongolia, China.
FAU - Li, Wei
AU  - Li W
AD  - Department of Otorhinolaryngology, The First Hospital of China Medical University 
      Shenyang 110001, Liaoning Province, China.
FAU - Ding, Xiaoxu
AU  - Ding X
AD  - Department of Otorhinolaryngology, The First Hospital of China Medical University 
      Shenyang 110001, Liaoning Province, China.
FAU - Yan, Aihui
AU  - Yan A
AD  - Department of Otorhinolaryngology, The First Hospital of China Medical University 
      Shenyang 110001, Liaoning Province, China.
LA  - eng
PT  - Journal Article
DEP - 20210615
PL  - United States
TA  - Am J Cancer Res
JT  - American journal of cancer research
JID - 101549944
PMC - PMC8263688
OTO - NOTNLM
OT  - IL-17 signaling pathways
OT  - Laryngeal squamous cell carcinoma
OT  - ethnic specificity
OT  - gene expression
COIS- None.
EDAT- 2021/07/13 06:00
MHDA- 2021/07/13 06:01
PMCR- 2021/06/15
CRDT- 2021/07/12 05:53
PHST- 2021/01/09 00:00 [received]
PHST- 2021/04/25 00:00 [accepted]
PHST- 2021/07/12 05:53 [entrez]
PHST- 2021/07/13 06:00 [pubmed]
PHST- 2021/07/13 06:01 [medline]
PHST- 2021/06/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Cancer Res. 2021 Jun 15;11(6):2684-2695. eCollection 2021.