PMID- 34250034
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210713
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 8
DP  - 2021
TI  - Methylenetetrahydrofolate Reductase Gene C677T Polymorphism-Dietary Pattern 
      Interaction on Hyperhomocysteinemia in a Chinese Population: A Cross-Sectional 
      Study.
PG  - 638322
LID - 10.3389/fcvm.2021.638322 [doi]
LID - 638322
AB  - Background and aim: Hyperhomocysteinemia (Hhcy) has been recognized as a risk 
      factor of several chronic diseases. There is accumulating evidence that both 
      genetic and dietary factors had a notable impact on the risk of Hhcy. The present 
      study aims to investigate the interaction effect on Hhcy between 
      methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and dietary 
      intake. Methods: Data were collected in a cross-sectional survey conducted in 
      China; 3,966 participants with complete information on sociodemographic 
      characteristics, anthropometric measurements, and dietary intake were included in 
      the analyses. Dietary patterns were identified by factor analysis combined with 
      cluster analysis. Blood samples were collected and MTHFR C677T genotypes were 
      tested. Both the multiplicative statistical model and the additive model were 
      conducted to investigate the interactive effects. Results: Proportions of MTHFR 
      C677T genotypes among participants were 29.2% for TT, 47.4% for CT, and 23.4% for 
      CC. Three dietary patterns were identified, namely, the balanced pattern, the 
      snack pattern, and the high-meat pattern. Compared with the balanced pattern, the 
      other two patterns were associated with an elevated risk of Hhcy [the snack 
      pattern: odds ratio (OR) 1.2, 95% confidence interval (CI) 1.0-1.5; the high-meat 
      pattern: OR 1.3, 95% CI 1.1-1.6] after adjustment for age group, gender, 
      residential region, and MTHFR C677T genotypes. A multiplicative interaction 
      between the high-meat pattern and MTHFR 677TT genotype was observed, and 
      synergistic effects between both the snack pattern and the high-meat pattern with 
      MTHFR 677TT were identified. Conclusion: Our results indicated that MTHFR C677T 
      polymorphism and dietary patterns had interactive effects on Hhcy among the 
      Chinese population. Subsequent targeted and appropriate dietary guidelines should 
      be recommended for high-risk populations or patients of Hhcy carrying specific 
      genotypes.
CI  - Copyright (c) 2021 Leng, Zhao, Zhang, Wu, Wang, Wu, Chen and Zeng.
FAU - Leng, Song
AU  - Leng S
AD  - Health Management Institute, The Second Medical Center & National Clinical 
      Research Center for Geriatric Diseases, Chinese People's Liberation Army General 
      Hospital, Beijing, China.
AD  - Health Management Center, The Second Hospital of Dalian Medical University, 
      Dalian, China.
FAU - Zhao, Ai
AU  - Zhao A
AD  - Vanke School of Public Health, Tsinghua University, Beijing, China.
FAU - Zhang, Jian
AU  - Zhang J
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing, China.
FAU - Wu, Wei
AU  - Wu W
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing, China.
FAU - Wang, Qian
AU  - Wang Q
AD  - Health Management Center, The Second Hospital of Dalian Medical University, 
      Dalian, China.
FAU - Wu, Shan
AU  - Wu S
AD  - Health Management Center, The Second Hospital of Dalian Medical University, 
      Dalian, China.
FAU - Chen, Li
AU  - Chen L
AD  - Health Management Center, The Second Hospital of Dalian Medical University, 
      Dalian, China.
FAU - Zeng, Qiang
AU  - Zeng Q
AD  - Health Management Institute, The Second Medical Center & National Clinical 
      Research Center for Geriatric Diseases, Chinese People's Liberation Army General 
      Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20210624
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC8263928
OTO - NOTNLM
OT  - MTHFR C677T
OT  - dietary pattern
OT  - hyperhomocysteinemia
OT  - interaction
OT  - methylenetetrahydrofolate reductase
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/07/13 06:00
MHDA- 2021/07/13 06:01
PMCR- 2021/01/01
CRDT- 2021/07/12 05:57
PHST- 2021/01/14 00:00 [received]
PHST- 2021/05/24 00:00 [accepted]
PHST- 2021/07/12 05:57 [entrez]
PHST- 2021/07/13 06:00 [pubmed]
PHST- 2021/07/13 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2021.638322 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2021 Jun 24;8:638322. doi: 10.3389/fcvm.2021.638322. 
      eCollection 2021.