PMID- 34250629
OWN - NLM
STAT- MEDLINE
DCOM- 20211116
LR  - 20211116
IS  - 1099-0844 (Electronic)
IS  - 0263-6484 (Linking)
VI  - 39
IP  - 7
DP  - 2021 Oct
TI  - IK: A novel cell mitosis regulator that contributes to carcinogenesis.
PG  - 854-859
LID - 10.1002/cbf.3660 [doi]
AB  - Carcinogenesis is characterized by abnormal regulation of cell growth and cell 
      death. IK is a novel cell mitosis regulator that may contribute to 
      carcinogenesis. Previous studies showed that the loss of IK expression resulted 
      in cell mitotic arrest and even cell death. Besides, IK can also inhibit the 
      interferon gamma (IFN-gamma)-induced expression of human leukocyte antigen (HLA) 
      class II antigen, which is associated with tumour immune microenvironment. To 
      gain insight into the current research progress regarding IK, we conducted a 
      review and searched the limited literature on IK using PubMed or Web of Science. 
      In this review, we discussed the possible biological functions and mechanisms of 
      IK in cancer and its immune microenvironment. Future perspectives of IK were also 
      mentioned to explore its clinical significance.
CI  - (c) 2021 John Wiley & Sons Ltd.
FAU - Gao, Chao
AU  - Gao C
AD  - Department of Gynecology and Obstetrics, Tianjin Medical University General 
      Hospital, Tianjin, China.
AD  - Tianjin Key Laboratory of Female Reproductive Health and Eugenics, Tianjin, 
      China.
FAU - Han, Yanyan
AU  - Han Y
AD  - Department of Pathology, First Teaching Hospital of Tianjin University of 
      Traditional Chinese Medicine, Tianjin, China.
FAU - Bai, Lu
AU  - Bai L
AD  - Department of Gynecology and Obstetrics, Tianjin Medical University General 
      Hospital, Tianjin, China.
AD  - Department of Gynecology and Obstetrics, Nankai University Affiliated Hospital 
      (Tianjin Fourth Hospital), Tianjin, China.
FAU - Wang, Yingmei
AU  - Wang Y
AD  - Department of Gynecology and Obstetrics, Tianjin Medical University General 
      Hospital, Tianjin, China.
AD  - Tianjin Key Laboratory of Female Reproductive Health and Eugenics, Tianjin, 
      China.
FAU - Xue, Fengxia
AU  - Xue F
AUID- ORCID: 0000-0001-9694-0061
AD  - Department of Gynecology and Obstetrics, Tianjin Medical University General 
      Hospital, Tianjin, China.
AD  - Tianjin Key Laboratory of Female Reproductive Health and Eugenics, Tianjin, 
      China.
LA  - eng
GR  - 81572568/National Natural Science Foundation of China/
GR  - 81772790/National Natural Science Foundation of China/
GR  - 20JCQNJC00480/Natural Science Foundation of Tianjin Municipal Science and 
      Technology Commission/
PT  - Journal Article
PT  - Review
DEP - 20210711
PL  - England
TA  - Cell Biochem Funct
JT  - Cell biochemistry and function
JID - 8305874
RN  - 0 (Cytokines)
RN  - 0 (IK protein, human)
SB  - IM
MH  - Carcinogenesis/*immunology
MH  - Cytokines/*immunology
MH  - Humans
MH  - Mitosis/*immunology
MH  - Tumor Microenvironment/immunology
OTO - NOTNLM
OT  - DNA damage
OT  - HLA
OT  - IK
OT  - cancer
OT  - cell mitosis
EDAT- 2021/07/13 06:00
MHDA- 2021/11/17 06:00
CRDT- 2021/07/12 06:11
PHST- 2021/06/26 00:00 [revised]
PHST- 2021/05/08 00:00 [received]
PHST- 2021/06/29 00:00 [accepted]
PHST- 2021/07/13 06:00 [pubmed]
PHST- 2021/11/17 06:00 [medline]
PHST- 2021/07/12 06:11 [entrez]
AID - 10.1002/cbf.3660 [doi]
PST - ppublish
SO  - Cell Biochem Funct. 2021 Oct;39(7):854-859. doi: 10.1002/cbf.3660. Epub 2021 Jul 
      11.