PMID- 34251551
OWN - NLM
STAT- MEDLINE
DCOM- 20211123
LR  - 20211123
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Print)
IS  - 1569-5794 (Linking)
VI  - 37
IP  - 12
DP  - 2021 Dec
TI  - Long term effects of mild severity COVID‑19 on right ventricular functions.
PG  - 3451-3457
LID - 10.1007/s10554-021-02340-x [doi]
AB  - Coronavirus disease 2019 (COVID-19) is a newly recognized infectious disease that 
      has spread rapidly. COVID-19 has been associated with a number of cardiovascular 
      involvements, including ventricular functions. The aim of our study was to 
      evaluate the right ventricular functions of mild severity COVID-19 patients 
      3 months after, and compare them to the right ventricular functions of healthy 
      volunteers. For this single-center study, data from 105 patients who were treated 
      for mild severity COVID-19 between September 15, 2020 and December 31, 2020 were 
      collected. 105 age and sex matched healthy subjects were included in the study. 
      Right ventricular (RV) functions were evaluated using conventional 
      two-dimensional (2D) echocardiography and 2D speckle-tracking echocardiography 
      (STE) for all patients. 2D-E parameters indicating RV functions were compared 
      between the two groups. RV diamaters, systolic pulmonary artery pressure (sPAP) 
      and RV myocardial performance index (RV MPI) were significantly higher in the 
      COVID-19 patients compared to control group (p < 0.05). Tricuspid annular plane 
      systolic motion (TAPSE), right ventricular fractional area change (RVFAC) and RV 
      S' were significantly lower in the COVID-19 group compared to control group 
      (p < 0.05). RV global longitudinal strain (RV-GLS) (- 19.6 +/- 5.2 vs. 
      - 15.1 +/- 3.4, p < 0.001) and RV free wall longitudinal strain RV-FWLS 
      (- 19.6 +/- 5.2 vs. - 17.2 +/- 4.4, p < 0.001) values were significantly lower in the 
      COVID-19 group than the control group. There was a significant negative 
      correlation between RV-FWLS, RV-GLS and C-reactive protein (CRP), neutrophil to 
      lymphocyte ratio (NLR), d-dimer, ferritin, platelet to lymphocyte ratio (PLR) in 
      patients with mild severity COVID-19. This results suggested that RV-GLS and 
      RV-FWLS decreased in the long term (third month) follow-up of patients treated 
      for mild severity COVID-19 disease. Subclinical RV dysfunction may be observed in 
      patients after mild severity COVID-19.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Akkaya, Fatih
AU  - Akkaya F
AUID- ORCID: 0000-0002-9016-4986
AD  - Department of Cardiology, Ordu University, Ordu, Turkey.
FAU - Yenercag, Feyza Nur Topcu
AU  - Yenercag FNT
AUID- ORCID: 0000-0003-1355-9607
AD  - Provincial Health Directorate, Ordu, Turkey.
FAU - Kaya, Ahmet
AU  - Kaya A
AUID- ORCID: 0000-0001-9845-7938
AD  - Department of Cardiology, Ordu University, Ordu, Turkey.
FAU - Sener, Yusuf Ziya
AU  - Sener YZ
AUID- ORCID: 0000-0001-5151-5133
AD  - Department of Cardiology, Beypazari State Hospital, Ankara, Turkey. 
      yzsener@yahoo.com.tr.
FAU - Bagci, Ali
AU  - Bagci A
AUID- ORCID: 0000-0002-8792-6329
AD  - Department of Cardiology, Suleyman Demirel University, Isparta, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20210712
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
SB  - IM
MH  - *COVID-19
MH  - Humans
MH  - Predictive Value of Tests
MH  - SARS-CoV-2
MH  - *Ventricular Dysfunction, Right/diagnostic imaging/etiology
MH  - Ventricular Function, Right
PMC - PMC8274467
OTO - NOTNLM
OT  - Coronavirus disease 2019
OT  - Right ventricular function
OT  - Speckle tracking echocardiography
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/07/13 06:00
MHDA- 2021/11/24 06:00
PMCR- 2021/07/12
CRDT- 2021/07/12 13:07
PHST- 2021/06/05 00:00 [received]
PHST- 2021/07/02 00:00 [accepted]
PHST- 2021/07/13 06:00 [pubmed]
PHST- 2021/11/24 06:00 [medline]
PHST- 2021/07/12 13:07 [entrez]
PHST- 2021/07/12 00:00 [pmc-release]
AID - 10.1007/s10554-021-02340-x [pii]
AID - 2340 [pii]
AID - 10.1007/s10554-021-02340-x [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2021 Dec;37(12):3451-3457. doi: 
      10.1007/s10554-021-02340-x. Epub 2021 Jul 12.