PMID- 34253885
OWN - NLM
STAT- MEDLINE
DCOM- 20211109
LR  - 20230204
IS  - 1881-1469 (Electronic)
IS  - 0021-8820 (Linking)
VI  - 74
IP  - 9
DP  - 2021 Sep
TI  - The nephroprotective properties of taurine-amikacin treatment in rats are 
      mediated through HSP25 and TLR-4 regulation.
PG  - 580-592
LID - 10.1038/s41429-021-00441-2 [doi]
AB  - Amikacin (AMK) is one of the most effective aminoglycoside antibiotics. However, 
      nephrotoxicity is a major deleterious and dose-limiting side effect associated 
      with its clinical use especially in high dose AMK-treated patients. The present 
      study assessed the ability of taurine (TAU) to alleviate or prevent AMK-induced 
      nephrotoxicity if co-administrated with AMK focusing on inflammation, apoptosis, 
      and fibrosis. Male Sprague Dawley rats were assigned to six equal groups. Group 
      1: rats received saline (normal control), group 2: normal rats received 
      50 mg kg(-1) TAU intraperitoneally (i.p.). Groups 3 and 4: received AMK (25 or 
      50 mg kg(-1); i.p.). Groups 5 and 6: received TAU (50 mg kg(-1); i.p.) 
      concurrently with AMK (25 or 50 mg kg(-1); i.p.) for 3 weeks. AMK-induced 
      nephrotoxicity is evidenced by elevated levels of serum creatinine (CRE), blood 
      urea nitrogen (BUN), and uric acid (UA). Histopathological investigations 
      provoked damaging changes in the renal tissues. Heat shock proteins (HSP)25 and 
      Toll-like receptor-4 (TLR-4) elevated levels were involved in the induction of 
      inflammatory reactions and focal fibrosis. The improved activation of TLR-4 may 
      stimulate monocytes to upgrade Interleukin (IL)-18 production rather than IL-10. 
      TAU proved therapeutic effectiveness against AMK-induced renal toxicity through 
      downregulation of HSP25, TLR-4, caspase-3, and IL-18 with up-regulation of IL-10 
      levels.
CI  - (c) 2021. The Author(s), under exclusive licence to the Japan Antibiotics Research 
      Association.
FAU - Madbouly, Neveen
AU  - Madbouly N
AD  - Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt. 
      aneveen@sci.cu.edu.eg.
FAU - Azmy, Ayman
AU  - Azmy A
AD  - Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt.
FAU - Salama, Abeer
AU  - Salama A
AD  - Pharmacology Department, National Research Centre, Cairo, Egypt.
FAU - El-Amir, Azza
AU  - El-Amir A
AD  - Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20210712
PL  - England
TA  - J Antibiot (Tokyo)
JT  - The Journal of antibiotics
JID - 0151115
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (HSP27 Heat-Shock Proteins)
RN  - 0 (Hspb1 protein, rat)
RN  - 0 (Tlr4 protein, rat)
RN  - 0 (Toll-Like Receptor 4)
RN  - 1EQV5MLY3D (Taurine)
RN  - 268B43MJ25 (Uric Acid)
RN  - 84319SGC3C (Amikacin)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Amikacin/administration & dosage/*toxicity
MH  - Animals
MH  - Anti-Bacterial Agents/administration & dosage/*toxicity
MH  - Apoptosis/drug effects
MH  - Blood Urea Nitrogen
MH  - Creatinine/blood
MH  - Dose-Response Relationship, Drug
MH  - Fibrosis/chemically induced/prevention & control
MH  - HSP27 Heat-Shock Proteins/metabolism
MH  - Inflammation/chemically induced/prevention & control
MH  - Kidney Diseases/chemically induced/*prevention & control
MH  - Male
MH  - Monocytes/drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Taurine/administration & dosage/*pharmacology
MH  - Toll-Like Receptor 4/metabolism
MH  - Uric Acid/blood
EDAT- 2021/07/14 06:00
MHDA- 2021/11/10 06:00
CRDT- 2021/07/13 06:22
PHST- 2021/02/19 00:00 [received]
PHST- 2021/06/15 00:00 [accepted]
PHST- 2021/07/14 06:00 [pubmed]
PHST- 2021/11/10 06:00 [medline]
PHST- 2021/07/13 06:22 [entrez]
AID - 10.1038/s41429-021-00441-2 [pii]
AID - 10.1038/s41429-021-00441-2 [doi]
PST - ppublish
SO  - J Antibiot (Tokyo). 2021 Sep;74(9):580-592. doi: 10.1038/s41429-021-00441-2. Epub 
      2021 Jul 12.