PMID- 34254320
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20220902
IS  - 1600-065X (Electronic)
IS  - 0105-2896 (Print)
IS  - 0105-2896 (Linking)
VI  - 303
IP  - 1
DP  - 2021 Sep
TI  - Plasma cell biology: Foundations for targeted therapeutic development in 
      transplantation.
PG  - 168-186
LID - 10.1111/imr.13011 [doi]
AB  - Solid organ transplantation is a life-saving procedure for patients with 
      end-stage organ disease. Over the past 70 years, tremendous progress has been 
      made in solid organ transplantation, particularly in T-cell-targeted 
      immunosuppression and organ allocation systems. However, humoral alloimmune 
      responses remain a major challenge to progress. Patients with preexisting 
      antibodies to human leukocyte antigen (HLA) are at significant disadvantages in 
      regard to receiving a well-matched organ, moreover, those who develop anti-HLA 
      antibodies after transplantation face a significant foreshortening of renal 
      allograft survival. Historical therapies to desensitize patients prior to 
      transplantation or to treat posttransplant AMR have had limited effectiveness, 
      likely because they do not significantly reduce antibody levels, as plasma cells, 
      the source of antibody production, remain largely unaffected. Herein, we will 
      discuss the significance of plasma cells in transplantation, aspects of their 
      biology as potential therapeutic targets, clinical challenges in developing 
      strategies to target plasma cells in transplantation, and lastly, novel 
      approaches that have potential to advance the field.
CI  - (c) 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Rossi, Amy P
AU  - Rossi AP
AUID- ORCID: 0000-0003-0629-0603
AD  - Division of Immunobiology, Cincinnati Children's Hospital Medical Center, 
      Cincinnati, OH, USA.
AD  - Department of Pediatrics, University of Cincinnati College of Medicine, 
      Cincinnati, OH, USA.
AD  - Immunology Graduate Program, University of Cincinnati College of Medicine, 
      Cincinnati, OH, USA.
AD  - Medical Scientist Training Program, University of Cincinnati College of Medicine, 
      Cincinnati, OH, USA.
FAU - Alloway, Rita R
AU  - Alloway RR
AUID- ORCID: 0000-0003-4835-9197
AD  - Division of Nephrology, Department of Internal Medicine, University of 
      Cincinnati, Cincinnati, OH, USA.
FAU - Hildeman, David
AU  - Hildeman D
AUID- ORCID: 0000-0002-0421-8483
AD  - Division of Immunobiology, Cincinnati Children's Hospital Medical Center, 
      Cincinnati, OH, USA.
AD  - Department of Pediatrics, University of Cincinnati College of Medicine, 
      Cincinnati, OH, USA.
AD  - Immunology Graduate Program, University of Cincinnati College of Medicine, 
      Cincinnati, OH, USA.
FAU - Woodle, E Steve
AU  - Woodle ES
AUID- ORCID: 0000-0003-4280-0842
AD  - Division of Transplantation, Department of Surgery, University of Cincinnati 
      College of Medicine, Cincinnati, OH, USA.
LA  - eng
GR  - R21 AI142264/AI/NIAID NIH HHS/United States
GR  - R01 AI154932/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210712
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Graft Rejection
MH  - HLA Antigens
MH  - Humans
MH  - Isoantibodies
MH  - *Kidney Transplantation
MH  - Plasma Cells
PMC - PMC8387355
MID - NIHMS1719312
OTO - NOTNLM
OT  - antibody-mediated rejection
OT  - desensitization
OT  - plasma cell
OT  - transplantation
COIS- CONFLICT OF INTEREST There is no conflict of Interest to declare.
EDAT- 2021/07/14 06:00
MHDA- 2021/10/26 06:00
PMCR- 2022/09/01
CRDT- 2021/07/13 06:41
PHST- 2021/06/08 00:00 [received]
PHST- 2021/06/22 00:00 [accepted]
PHST- 2021/07/14 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/07/13 06:41 [entrez]
PHST- 2022/09/01 00:00 [pmc-release]
AID - 10.1111/imr.13011 [doi]
PST - ppublish
SO  - Immunol Rev. 2021 Sep;303(1):168-186. doi: 10.1111/imr.13011. Epub 2021 Jul 12.