PMID- 34255108
OWN - NLM
STAT- MEDLINE
DCOM- 20211102
LR  - 20211102
IS  - 1432-0800 (Electronic)
IS  - 0007-4861 (Linking)
VI  - 107
IP  - 5
DP  - 2021 Nov
TI  - Gene Expression Changes in Epinephelus marginatus (Teleostei, Serranidae) Liver 
      as Molecular Biomarker of Iron Ore Contamination.
PG  - 855-859
LID - 10.1007/s00128-021-03324-2 [doi]
AB  - The aim of this study was to determine selected molecular biomarkers of iron ore 
      contamination in Epinephelus marginatus. Molecular biomarkers were tested by 
      checking the relative expression of genes involved in oxidative stress, trace 
      element regulation, and cellular damage, by RT-qPCR. Iron ore exposure caused the 
      downregulation of ferroportin (FP) gene expression and a significant upregulation 
      in superoxide dismutase (SOD) and cytochrome P450 1A (CYP1A) genes. Iron ore 
      affects gene expression in E. marginatus liver, indicating that it can 
      potentially induce toxic effects in fish. Moreover, this altered gene expression 
      pattern may be applied in monitoring iron ore contamination in marine 
      environments.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Gomes, Aline Silva
AU  - Gomes AS
AD  - Universidade Vila Velha, Rua Comissario Jose Dantas Melo, 21, Vila Velha, ES, 
      29102-770, Brazil.
FAU - Boldrini-Franca, Johara
AU  - Boldrini-Franca J
AUID- ORCID: 0000-0002-9444-7481
AD  - Universidade Vila Velha, Rua Comissario Jose Dantas Melo, 21, Vila Velha, ES, 
      29102-770, Brazil. joharafran@gmail.com.
FAU - Aride, Paulo Henrique Rocha
AU  - Aride PHR
AD  - Instituto Federal Do Amazonas, Rua Sete de Setembro, 1975, Manaus, AM, 69020-120, 
      Brazil.
FAU - Gomes, Levy Carvalho
AU  - Gomes LC
AD  - Universidade Vila Velha, Rua Comissario Jose Dantas Melo, 21, Vila Velha, ES, 
      29102-770, Brazil. levy.gomes@uvv.br.
LA  - eng
GR  - 01/2015/Fundacao Estadual de Amparo a Pesquisa do Estado do Espirito Santo/
GR  - 570/2018/Fundacao Estadual de Amparo a Pesquisa do Estado do Espirito Santo/
GR  - 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/
PT  - Journal Article
DEP - 20210713
PL  - United States
TA  - Bull Environ Contam Toxicol
JT  - Bulletin of environmental contamination and toxicology
JID - 0046021
RN  - 0 (Biomarkers)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Animals
MH  - *Bass
MH  - Biomarkers
MH  - Gene Expression
MH  - Iron
MH  - Liver
OTO - NOTNLM
OT  - Aquatic pollution
OT  - Ferroportin
OT  - Gene expression
OT  - Grouper
OT  - Iron ore
EDAT- 2021/07/14 06:00
MHDA- 2021/11/03 06:00
CRDT- 2021/07/13 12:23
PHST- 2021/02/18 00:00 [received]
PHST- 2021/06/24 00:00 [accepted]
PHST- 2021/07/14 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
PHST- 2021/07/13 12:23 [entrez]
AID - 10.1007/s00128-021-03324-2 [pii]
AID - 10.1007/s00128-021-03324-2 [doi]
PST - ppublish
SO  - Bull Environ Contam Toxicol. 2021 Nov;107(5):855-859. doi: 
      10.1007/s00128-021-03324-2. Epub 2021 Jul 13.