PMID- 34255294 OWN - NLM STAT- MEDLINE DCOM- 20220318 LR - 20221207 IS - 1868-4297 (Electronic) IS - 1868-4300 (Print) IS - 1868-4297 (Linking) VI - 37 IP - 2 DP - 2022 Apr TI - Percutaneous coronary intervention for left main coronary artery malperfusion in acute type A aortic dissection. PG - 333-342 LID - 10.1007/s12928-021-00793-4 [doi] AB - The clinical outcomes of patients undergoing percutaneous coronary intervention (PCI) for left main coronary artery (LMCA) malperfusion caused by acute type A aortic dissection (AAAD) remains largely unexplored. The aim of this study was to determine the clinical outcomes of patients undergoing PCI for LMCA malperfusion caused by AAAD. We examined nine consecutive patients undergoing PCI for LMCA malperfusion caused by AAAD between 1995 and 2020. The mean age was 55.4 +/- 7.7 years. Eight patients presented cardiogenic shock, and five patients cardiopulmonary arrest. Two patients were diagnosed with AAAD before coronary angiography using computed tomography and transthoracic echocardiography, respectively, and in the other seven patients after coronary angiography using other modalities. Four patients underwent PCI on intra-aortic balloon pumping support, and four patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO) support, including one patient on both. PCI was successful in eight patients, with final thrombolysis in myocardial infarction grade 2 or 3. The four patients on VA-ECMO did not undergo aortic dissection repair due to poor recovery of cardiac function and died during the hospital stay, and the other five patients had successful PCI, underwent aortic dissection repair, and remained alive at 5 year follow-up. In conclusion, LMCA malperfusion caused by AAAD seemed to have clinical presentations and electrocardiogram changes similar to acute coronary syndrome. PCI and subsequent surgical aortic repair saved the lives of all AAAD patients with LMCA malperfusion who had not required VA-ECMO. CI - (c) 2021. The Author(s). FAU - Taguchi, Yuya AU - Taguchi Y AD - Department of Cardiovascular Medicine, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki, 710-8602, Japan. yuya_handball_13@yahoo.co.jp. FAU - Kubo, Shunsuke AU - Kubo S AD - Department of Cardiovascular Medicine, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki, 710-8602, Japan. FAU - Ikuta, Akihiro AU - Ikuta A AD - Department of Cardiovascular Medicine, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki, 710-8602, Japan. FAU - Osakada, Kohei AU - Osakada K AD - Department of Cardiovascular Medicine, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki, 710-8602, Japan. FAU - Takamatsu, Makoto AU - Takamatsu M AD - Department of Cardiovascular Medicine, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki, 710-8602, Japan. FAU - Takahashi, Kotaro AU - Takahashi K AD - Department of Cardiovascular Medicine, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki, 710-8602, Japan. FAU - Ohya, Masanobu AU - Ohya M AD - Department of Cardiovascular Medicine, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki, 710-8602, Japan. FAU - Shimada, Takenobu AU - Shimada T AD - Department of Cardiovascular Medicine, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki, 710-8602, Japan. FAU - Miura, Katsuya AU - Miura K AD - Department of Cardiovascular Medicine, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki, 710-8602, Japan. FAU - Murai, Ryosuke AU - Murai R AD - Department of Cardiovascular Medicine, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki, 710-8602, Japan. FAU - Tada, Takeshi AU - Tada T AD - Department of Cardiovascular Medicine, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki, 710-8602, Japan. FAU - Tanaka, Hiroyuki AU - Tanaka H AD - Department of Cardiovascular Medicine, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki, 710-8602, Japan. FAU - Fuku, Yasushi AU - Fuku Y AD - Department of Cardiovascular Medicine, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki, 710-8602, Japan. FAU - Goto, Tsuyoshi AU - Goto T AD - Department of Cardiovascular Medicine, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki, 710-8602, Japan. FAU - Komiya, Tatsuhiko AU - Komiya T AD - Department of Cardiovascular Surgery, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki, Japan. FAU - Kadota, Kazushige AU - Kadota K AD - Department of Cardiovascular Medicine, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki, 710-8602, Japan. LA - eng PT - Journal Article DEP - 20210713 PL - Japan TA - Cardiovasc Interv Ther JT - Cardiovascular intervention and therapeutics JID - 101522043 SB - IM MH - *Aortic Dissection/complications/diagnosis/surgery MH - Coronary Vessels/diagnostic imaging/surgery MH - Humans MH - Middle Aged MH - *Percutaneous Coronary Intervention/methods MH - Shock, Cardiogenic/etiology MH - Treatment Outcome PMC - PMC8926951 OTO - NOTNLM OT - Acute type A aortic dissection OT - Left main coronary artery malperfusion OT - Percutaneous coronary intervention COIS- The authors have no conflicts of interest to disclose. EDAT- 2021/07/14 06:00 MHDA- 2022/03/19 06:00 PMCR- 2021/07/13 CRDT- 2021/07/13 12:29 PHST- 2021/02/15 00:00 [received] PHST- 2021/07/02 00:00 [accepted] PHST- 2021/07/14 06:00 [pubmed] PHST- 2022/03/19 06:00 [medline] PHST- 2021/07/13 12:29 [entrez] PHST- 2021/07/13 00:00 [pmc-release] AID - 10.1007/s12928-021-00793-4 [pii] AID - 793 [pii] AID - 10.1007/s12928-021-00793-4 [doi] PST - ppublish SO - Cardiovasc Interv Ther. 2022 Apr;37(2):333-342. doi: 10.1007/s12928-021-00793-4. Epub 2021 Jul 13.