PMID- 34255827
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20220401
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Linking)
VI  - 32
IP  - 2
DP  - 2022 Jan 10
TI  - Hidden Markov Modeling Reveals Prolonged "Baseline" State and Shortened 
      Antagonistic State across the Adult Lifespan.
PG  - 439-453
LID - 10.1093/cercor/bhab220 [doi]
AB  - The brain networks undergo functional reorganization across the whole lifespan, 
      but the dynamic patterns behind the reorganization remain largely unclear. This 
      study models the dynamics of spontaneous activity of large-scale networks using 
      hidden Markov model (HMM), and investigates how it changes with age on two adult 
      lifespan datasets of 176/157 subjects (aged 20-80 years). Results for both 
      datasets showed that 1) older adults tended to spend less time on a state where 
      default mode network (DMN) and attentional networks show antagonistic activity, 
      2) older adults spent more time on a "baseline" state with moderate-level 
      activation of all networks, accompanied with lower transition probabilities from 
      this state to the others and higher transition probabilities from the others to 
      this state, and 3) HMM exhibited higher sensitivity in uncovering the age effects 
      compared with temporal clustering method. Our results suggest that the aging 
      brain is characterized by the shortening of the antagonistic instances between 
      DMN and attention systems, as well as the prolongation of the inactive period of 
      all networks, which might reflect the shift of the dynamical working point near 
      criticality in older adults.
CI  - (c) The Author(s) 2021. Published by Oxford University Press. All rights reserved. 
      For permissions, please e-mail: journals.permissions@oup.com.
FAU - Chen, Keyu
AU  - Chen K
AD  - Research Center of Brain and Cognitive Neuroscience, Liaoning Normal University, 
      Dalian 116029, China.
AD  - Key Laboratory of Brain and Cognitive Neuroscience, Dalian 116029, Liaoning 
      Province, China.
FAU - Li, Chaofan
AU  - Li C
AD  - Research Center of Brain and Cognitive Neuroscience, Liaoning Normal University, 
      Dalian 116029, China.
AD  - Key Laboratory of Brain and Cognitive Neuroscience, Dalian 116029, Liaoning 
      Province, China.
FAU - Sun, Wei
AU  - Sun W
AD  - Research Center of Brain and Cognitive Neuroscience, Liaoning Normal University, 
      Dalian 116029, China.
AD  - Key Laboratory of Brain and Cognitive Neuroscience, Dalian 116029, Liaoning 
      Province, China.
FAU - Tao, Yunyun
AU  - Tao Y
AD  - Research Center of Brain and Cognitive Neuroscience, Liaoning Normal University, 
      Dalian 116029, China.
AD  - Key Laboratory of Brain and Cognitive Neuroscience, Dalian 116029, Liaoning 
      Province, China.
FAU - Wang, Ruidi
AU  - Wang R
AD  - Research Center of Brain and Cognitive Neuroscience, Liaoning Normal University, 
      Dalian 116029, China.
AD  - Key Laboratory of Brain and Cognitive Neuroscience, Dalian 116029, Liaoning 
      Province, China.
FAU - Hou, Wen
AU  - Hou W
AD  - School of Mathematics, Liaoning Normal University, Dalian 116029, China.
FAU - Liu, Dong-Qiang
AU  - Liu DQ
AUID- ORCID: 0000-0001-5657-5338
AD  - Research Center of Brain and Cognitive Neuroscience, Liaoning Normal University, 
      Dalian 116029, China.
AD  - Key Laboratory of Brain and Cognitive Neuroscience, Dalian 116029, Liaoning 
      Province, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain/physiology
MH  - Brain Mapping/methods
MH  - Humans
MH  - *Longevity
MH  - Magnetic Resonance Imaging/methods
MH  - Middle Aged
MH  - *Nerve Net/physiology
MH  - Young Adult
OTO - NOTNLM
OT  - adult lifespan
OT  - hidden Markov model
OT  - resting state fMRI
EDAT- 2021/07/14 06:00
MHDA- 2022/04/01 06:00
CRDT- 2021/07/13 17:29
PHST- 2021/01/31 00:00 [received]
PHST- 2021/06/10 00:00 [revised]
PHST- 2021/06/11 00:00 [accepted]
PHST- 2021/07/14 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
PHST- 2021/07/13 17:29 [entrez]
AID - 6319927 [pii]
AID - 10.1093/cercor/bhab220 [doi]
PST - ppublish
SO  - Cereb Cortex. 2022 Jan 10;32(2):439-453. doi: 10.1093/cercor/bhab220.