PMID- 34256418
OWN - NLM
STAT- MEDLINE
DCOM- 20211125
LR  - 20221005
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Print)
IS  - 0951-418X (Linking)
VI  - 35
IP  - 11
DP  - 2021 Nov
TI  - Contribution of traditional Chinese medicine combined with conventional western 
      medicine treatment for the novel coronavirus disease (COVID-19), current evidence 
      with systematic review and meta-analysis.
PG  - 5992-6009
LID - 10.1002/ptr.7209 [doi]
AB  - This study provides current evidence for efficacy and safety of treating COVID-19 
      with combined traditional Chinese medicine (TCM) and conventional western 
      medicine (CWM). Six databases were searched from January 1 to December 31, 2020. 
      Randomized controlled trials (RCTs), case-control studies (CCTs), and cohort 
      studies on TCM or TCM combined with CWM treatment for COVID-19 were included. The 
      quality of included RCTs was assessed by Cochrane risk of bias tool, and the 
      Newcastle-Ottawa Scale (NOS) was used to assess the quality of cohort studies and 
      CCTs. Review Manager 5.4 software was used to perform meta-analysis. The quality 
      of evidence was assessed using the Grading of Recommendations Assessment, 
      Development and Evaluation (GRADE) approach. A total of 35 studies (3,808 
      patients) composing 19 RCTs and 16 observational studies were included. The 
      results of meta-analysis revealed that comparing with CWM alone, integrated TCM 
      and CWM had significant improvement in total effective rate, improvement rate of 
      chest CT, the rate of disease progression, as well as improvement of fever, 
      fatigue and cough. The overall quality of evidence was very low to moderate. In 
      conclusion, TCM combined with CWM was a potential treatment option for increasing 
      clinical effective rate, improving the clinical symptoms, and preventing disease 
      progression in COVID-19 patients. High-quality clinical trials are required in 
      the further.
CI  - (c) 2021 John Wiley & Sons Ltd.
FAU - Jiang, Fei
AU  - Jiang F
AUID- ORCID: 0000-0002-4462-0549
AD  - The Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province and 
      School of Life Sciences, Jiangsu Normal University, Xuzhou, China.
AD  - Department of Laboratory Medicine, the Affiliated Hospital of Xuzhou Medical 
      University, Xuzhou, China.
FAU - Xu, Nana
AU  - Xu N
AD  - The Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province and 
      School of Life Sciences, Jiangsu Normal University, Xuzhou, China.
AD  - Department of Morphology, Xuzhou Medical University, Xuzhou, China.
FAU - Zhou, Yanxi
AU  - Zhou Y
AD  - School of Medical Technology, Xuzhou Medical University, Xuzhou, China.
FAU - Song, Jinxing
AU  - Song J
AD  - The Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province and 
      School of Life Sciences, Jiangsu Normal University, Xuzhou, China.
FAU - Liu, Jinjuan
AU  - Liu J
AD  - The Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province and 
      School of Life Sciences, Jiangsu Normal University, Xuzhou, China.
FAU - Zhu, Hong
AU  - Zhu H
AD  - Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, 
      China.
FAU - Jiang, Jihong
AU  - Jiang J
AD  - The Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province and 
      School of Life Sciences, Jiangsu Normal University, Xuzhou, China.
FAU - Xu, Yonghong
AU  - Xu Y
AD  - The Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province and 
      School of Life Sciences, Jiangsu Normal University, Xuzhou, China.
FAU - Li, Rongpeng
AU  - Li R
AD  - The Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province and 
      School of Life Sciences, Jiangsu Normal University, Xuzhou, China.
LA  - eng
GR  - 81870005/National Natural Science Foundation of China/
GR  - 18KJA180003/Natural Science Foundation of the Jiangsu Higher Education 
      Institutions of China/
GR  - Priority Academic Program Development of Jiangsu Higher Education Institutions 
      (PAPD)/
GR  - KC20102/Project of Xuzhou Applied and Basic Research/
GR  - KC18009/Project of Xuzhou Applied and Basic Research/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20210713
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - *COVID-19
MH  - *Drugs, Chinese Herbal/therapeutic use
MH  - Humans
MH  - Medicine, Chinese Traditional
MH  - SARS-CoV-2
MH  - Treatment Outcome
PMC - PMC8441775
OTO - NOTNLM
OT  - COVID-19
OT  - integrative medicine
OT  - meta-analysis
OT  - systematic review
OT  - traditional Chinese medicine
COIS- The authors declared that there was no conflict of interest regarding the 
      publication of this paper.
EDAT- 2021/07/14 06:00
MHDA- 2021/11/26 06:00
PMCR- 2021/07/13
CRDT- 2021/07/13 20:26
PHST- 2021/05/12 00:00 [revised]
PHST- 2021/02/07 00:00 [received]
PHST- 2021/06/02 00:00 [accepted]
PHST- 2021/07/14 06:00 [pubmed]
PHST- 2021/11/26 06:00 [medline]
PHST- 2021/07/13 20:26 [entrez]
PHST- 2021/07/13 00:00 [pmc-release]
AID - PTR7209 [pii]
AID - 10.1002/ptr.7209 [doi]
PST - ppublish
SO  - Phytother Res. 2021 Nov;35(11):5992-6009. doi: 10.1002/ptr.7209. Epub 2021 Jul 
      13.