PMID- 34257522
OWN - NLM
STAT- MEDLINE
DCOM- 20220107
LR  - 20220424
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2021
DP  - 2021
TI  - Unfractionated Heparin Improves the Intestinal Microcirculation in a Canine 
      Septic Shock Model.
PG  - 9985397
LID - 10.1155/2021/9985397 [doi]
LID - 9985397
AB  - BACKGROUND: Alterations of microcirculation are associated with organ 
      hypoperfusion and high mortality in septic shock. This study is aimed at 
      investigating the effects of unfractionated heparin (UFH) on intestinal 
      microcirculatory perfusion and systemic circulation in a septic shock model. 
      METHODS: Twenty-four beagle dogs were randomly allocated into four groups: (a) 
      sham group: healthy controls, (b) shock group: septic shock induced by 
      Escherichia coli, (c) basic therapy group: septic shock animals treated with 
      antibiotics and 10 ml/kg/h saline, and (d) heparin group: septic shock animals 
      treated with basic therapy plus UFH. Hemodynamic variables were measured within 
      24 h after E. coli administration. The intestinal microcirculation was 
      simultaneously investigated with a sidestream dark-field imaging technique. 
      Additionally, the function of vital organs was evaluated at 12 h 
      postadministration (T12). RESULTS: E. coli induced a progressive septic shock in 
      which the mean arterial pressure (MAP) decreased and lactate levels sharply 
      increased, accompanied by deteriorated microvessel perfusion. While basic therapy 
      partially improved the microvascular flow index and the perfused microvessel 
      density in the jejunal villi, UFH significantly restored major microcirculation 
      variables at T12. Physiological variables, including MAP, urine output, and 
      lactate levels, were improved by UFH, whereas some hemodynamic indices were not 
      affected by UFH. With respect to organ function, UFH increased the platelet count 
      and decreased the creatinine level. CONCLUSIONS: UFH improves microcirculatory 
      perfusion of the small intestine independently of the changes in systemic 
      hemodynamic variables in a canine model of septic shock, thereby improving 
      coagulation and renal function.
CI  - Copyright (c) 2021 Heng Zhang et al.
FAU - Zhang, Heng
AU  - Zhang H
AD  - Department of Neurosurgery, The First Affiliated Hospital of China Medical 
      University, Shenyang, China.
FAU - Sun, Yini
AU  - Sun Y
AUID- ORCID: 0000-0003-4399-137X
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of China 
      Medical University, Shenyang, China.
FAU - An, Xin
AU  - An X
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of China 
      Medical University, Shenyang, China.
FAU - Ma, Xiaochun
AU  - Ma X
AUID- ORCID: 0000-0002-1714-9800
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of China 
      Medical University, Shenyang, China.
LA  - eng
PT  - Journal Article
DEP - 20210623
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Dogs
MH  - Escherichia coli
MH  - Female
MH  - Hemodynamics
MH  - Heparin/*metabolism
MH  - Intestinal Mucosa/*drug effects
MH  - Intestines/blood supply/*drug effects
MH  - Male
MH  - *Microcirculation
MH  - Perfusion
MH  - Shock, Septic/drug therapy/*metabolism
PMC - PMC8245220
COIS- The authors declare that they have no competing interest.
EDAT- 2021/07/15 06:00
MHDA- 2022/01/08 06:00
PMCR- 2021/06/23
CRDT- 2021/07/14 07:01
PHST- 2021/03/28 00:00 [received]
PHST- 2021/05/21 00:00 [accepted]
PHST- 2021/07/14 07:01 [entrez]
PHST- 2021/07/15 06:00 [pubmed]
PHST- 2022/01/08 06:00 [medline]
PHST- 2021/06/23 00:00 [pmc-release]
AID - 10.1155/2021/9985397 [doi]
PST - epublish
SO  - Mediators Inflamm. 2021 Jun 23;2021:9985397. doi: 10.1155/2021/9985397. 
      eCollection 2021.