PMID- 34258179
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220424
IS  - 2211-3355 (Print)
IS  - 2211-3355 (Electronic)
IS  - 2211-3355 (Linking)
VI  - 23
DP  - 2021 Sep
TI  - Do Weight trajectories influence diabetes control? A prospective study in 
      Switzerland (CoLaus study).
PG  - 101473
LID - 10.1016/j.pmedr.2021.101473 [doi]
LID - 101473
AB  - OBJECTIVE: Identify anthropometric trajectories among subjects with type 2 
      diabetes mellitus (T2DM), and associate them with glycaemic control. METHODS: 
      Prospective study including 268 community-dwelling participants with T2DM (34% 
      women, mean age 68.7 +/- 8.9 years) followed for 10.7 years (range: 
      8.8-13.6 years). T2DM control was considered for 1) fasting plasma glucose 
      (FPG) < 7.0 mmol/L, or 2) HbA(1)c < 7.0% (53 nmol/mol). Changes in weight or 
      waist and weight variability were considered. RESULTS: One half (FPG) and one 
      third (HbA(1)c) of participants presented with uncontrolled T2DM. Half of the 
      participants presented with obesity and 75% with abdominal obesity. During 
      follow-up, half of the participants maintained their weight, 25% gained > 5 kg, 
      and 25% lost < 5 kg; almost half increased their waist by > 5 cm. Using FPG as 
      criterion, participants who lost > 5 cm waist were more likely to be controlled: 
      multivariable-adjusted odds ratio (OR) and 95% confidence interval (CI): 3.10 
      (1.23-7.78). Participants with controlled T2DM also presented with a higher 
      weight variability: multivariable adjusted mean +/- standard error 4.8 +/- 0.3 vs. 
      3.9 +/- 0.3 kg, p = 0.028. Using HbA(1)c as criterion, participants who lost > 5 kg 
      were less likely to be controlled: OR and (95% CI): 0.35 (0.18-0.66). Similar 
      findings were obtained when restricting the analysis to participants who were 
      diabetic throughout the whole study period. CONCLUSION: In a Swiss 
      community-based sample of participants with T2DM, T2DM control rates could be 
      implemented. Neither weight nor waist variability was significantly and 
      consistently associated with T2DM control.
CI  - (c) 2021 The Authors.
FAU - Ducraux, Pauline
AU  - Ducraux P
AD  - Department of Medicine, Internal Medicine, Lausanne University Hospital and 
      University of Lausanne, 46 rue du Bugnon, 1011 Lausanne, Switzerland.
FAU - Waeber, Gerard
AU  - Waeber G
AD  - Department of Medicine, Internal Medicine, Lausanne University Hospital and 
      University of Lausanne, 46 rue du Bugnon, 1011 Lausanne, Switzerland.
FAU - Marques-Vidal, Pedro
AU  - Marques-Vidal P
AD  - Department of Medicine, Internal Medicine, Lausanne University Hospital and 
      University of Lausanne, 46 rue du Bugnon, 1011 Lausanne, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20210627
PL  - United States
TA  - Prev Med Rep
JT  - Preventive medicine reports
JID - 101643766
PMC - PMC8259406
OTO - NOTNLM
OT  - Diabetes
OT  - Diabetes management
OT  - Epidemiology
OT  - Waist
OT  - Weight
OT  - Weight variability
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2021/07/15 06:00
MHDA- 2021/07/15 06:01
PMCR- 2021/06/27
CRDT- 2021/07/14 07:08
PHST- 2020/11/18 00:00 [received]
PHST- 2021/04/13 00:00 [revised]
PHST- 2021/06/23 00:00 [accepted]
PHST- 2021/07/14 07:08 [entrez]
PHST- 2021/07/15 06:00 [pubmed]
PHST- 2021/07/15 06:01 [medline]
PHST- 2021/06/27 00:00 [pmc-release]
AID - S2211-3355(21)00163-7 [pii]
AID - 101473 [pii]
AID - 10.1016/j.pmedr.2021.101473 [doi]
PST - epublish
SO  - Prev Med Rep. 2021 Jun 27;23:101473. doi: 10.1016/j.pmedr.2021.101473. 
      eCollection 2021 Sep.