PMID- 34259837
OWN - NLM
STAT- MEDLINE
DCOM- 20220511
LR  - 20240324
IS  - 1464-3685 (Electronic)
IS  - 0300-5771 (Print)
IS  - 0300-5771 (Linking)
VI  - 51
IP  - 2
DP  - 2022 May 9
TI  - Plasma concentrations of persistent organic pollutants and pancreatic cancer 
      risk.
PG  - 479-490
LID - 10.1093/ije/dyab115 [doi]
AB  - BACKGROUND: Findings and limitations of previous studies on persistent organic 
      pollutants (POPs) and pancreatic cancer risk support conducting further research 
      in prospective cohorts. METHODS: We conducted a prospective case-control study 
      nested within the European Prospective Investigation into Cancer and Nutrition 
      (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched 
      controls. Concentrations of 22 POPs were measured in plasma collected at 
      baseline. RESULTS: Some associations were observed at higher concentrations of p, 
      p'-DDT, trans-nonachlor, beta-hexachlorocyclohexane and the sum of six 
      organochlorine pesticides and of 16 POPs. The odds ratio (OR) for the upper 
      quartile of trans-nonachlor was 1.55 (95% confidence interval 1.06-2.26; P for 
      trend = 0.025). Associations were stronger in the groups predefined as most valid 
      (participants having fasted >6 h, with microscopic diagnostic confirmation, 
      normal weight, and never smokers), and as most relevant (follow-up >/=10 years). 
      Among participants having fasted >6 h, the ORs were relevant for 10 of 11 
      exposures. Higher ORs were also observed among cases with microscopic 
      confirmation than in cases with a clinical diagnosis, and among normal-weight 
      participants than in the rest of participants. Among participants with a 
      follow-up >/=10 years, estimates were higher than in participants with a shorter 
      follow-up (for trans-nonachlor: OR = 2.14, 1.01 to 4.53, P for trend = 0.035). 
      Overall, trans-nonachlor, three PCBs and the two sums of POPs were the exposures 
      most clearly associated with pancreatic cancer risk. CONCLUSIONS: Individually or 
      in combination, most of the 22 POPs analysed did not or only moderately increased 
      the risk of pancreatic cancer.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      International Epidemiological Association.
FAU - Porta, Miquel
AU  - Porta M
AUID- ORCID: 0000-0003-1684-7428
AD  - Hospital del Mar Institute of Medical Research (IMIM PSMar), Barcelona, 
      Catalonia, Spain.
AD  - Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain.
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
FAU - Gasull, Magda
AU  - Gasull M
AD  - Hospital del Mar Institute of Medical Research (IMIM PSMar), Barcelona, 
      Catalonia, Spain.
AD  - Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain.
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
FAU - Pumarega, Jose
AU  - Pumarega J
AD  - Hospital del Mar Institute of Medical Research (IMIM PSMar), Barcelona, 
      Catalonia, Spain.
AD  - Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain.
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
FAU - Kiviranta, Hannu
AU  - Kiviranta H
AD  - Department of Health Security, National Institute for Health and Welfare, Kuopio, 
      Finland.
FAU - Rantakokko, Panu
AU  - Rantakokko P
AD  - Department of Health Security, National Institute for Health and Welfare, Kuopio, 
      Finland.
FAU - Raaschou-Nielsen, Ole
AU  - Raaschou-Nielsen O
AD  - Danish Cancer Society Research Center, Copenhagen, Denmark.
FAU - Bergdahl, Ingvar A
AU  - Bergdahl IA
AD  - Department of Biobank Research, Umea University, Umea, Sweden.
AD  - Occupational and Environmental Medicine, Department of Public Health and Clinical 
      Medicine, Umea University, Umea, Sweden.
FAU - Sandanger, Torkjel Manning
AU  - Sandanger TM
AD  - Department of Community Medicine, UiT-The Arctic University of Norway, Tromso, 
      Norway.
FAU - Agudo, Antoni
AU  - Agudo A
AD  - Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), 
      Barcelona, Spain.
FAU - Rylander, Charlotta
AU  - Rylander C
AD  - Department of Community Medicine, UiT-The Arctic University of Norway, Tromso, 
      Norway.
FAU - Nost, Therese Haugdahl
AU  - Nost TH
AD  - Department of Community Medicine, UiT-The Arctic University of Norway, Tromso, 
      Norway.
FAU - Donat-Vargas, Carolina
AU  - Donat-Vargas C
AD  - Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, 
      Karolinska Institutet, Stockholm, Sweden.
AD  - Department of Preventive Medicine and Public Health, School of Medicine, 
      Universidad Autonoma de Madrid, CEI UAM+CSIC, Madrid, Spain.
FAU - Aune, Dagfinn
AU  - Aune D
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Imperial 
      College London, London, UK.
FAU - Heath, Alicia K
AU  - Heath AK
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Imperial 
      College London, London, UK.
FAU - Cirera, Lluis
AU  - Cirera L
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
AD  - Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, 
      Murcia, Spain.
AD  - Department of Health and Social Sciences, University of Murcia, Murcia, Spain.
FAU - Goni-Irigoyen, Fernando
AU  - Goni-Irigoyen F
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
AD  - Health Department of Basque Government, Public Health Laboratory in Gipuzkoa, San 
      Sebastian, Spain.
AD  - Health Research Institute Biodonostia, San Sebastian, Spain.
FAU - Alguacil, Juan
AU  - Alguacil J
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
AD  - University of Huelva, Huelva, Spain.
FAU - Gimenez-Robert, Alex
AU  - Gimenez-Robert A
AD  - Hospital del Mar Institute of Medical Research (IMIM PSMar), Barcelona, 
      Catalonia, Spain.
AD  - Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain.
FAU - Tjonneland, Anne
AU  - Tjonneland A
AD  - Danish Cancer Society Research Center, Copenhagen, Denmark.
FAU - Sund, Malin
AU  - Sund M
AD  - Department of Surgical and Perioperative Sciences, Umea University, Umea, Sweden.
FAU - Overvad, Kim
AU  - Overvad K
AD  - Department of Public Health, Aarhus University, Aarhus, Denmark.
FAU - Mancini, Francesca Romana
AU  - Mancini FR
AD  - CESP, Faculte de medecine (USVQ), Universite Paris-Sud, INSERM, Universite 
      Paris-Saclay, Villejuif, France.
AD  - Inserm UMR1018, Institut Gustave Roussy, Villejuif, France.
FAU - Rebours, Vinciane
AU  - Rebours V
AD  - Pancreatology Department, Beaujon Hospital, AP-HP, Clichy, France.
AD  - Inserm UMR1149, DHU Unit, Paris-Diderot University, Paris, France.
FAU - Boutron-Ruault, Marie-Christine
AU  - Boutron-Ruault MC
AD  - CESP, Faculte de medecine (USVQ), Universite Paris-Sud, INSERM, Universite 
      Paris-Saclay, Villejuif, France.
AD  - Inserm UMR1018, Institut Gustave Roussy, Villejuif, France.
FAU - Kaaks, Rudolf
AU  - Kaaks R
AD  - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 
      Heidelberg, Germany.
FAU - Schulze, Matthias B
AU  - Schulze MB
AD  - Department of Molecular Epidemiology, German Institute of Human Nutrition 
      Potsdam, Rehbruecke, Nuthetal, Germany.
AD  - Institute of Nutrition Science, University of Potsdam, Nuthetal, Germany.
FAU - Trichopoulou, Antonia
AU  - Trichopoulou A
AD  - Hellenic Health Foundation, Athens, Greece.
FAU - Palli, Domenico
AU  - Palli D
AD  - Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer 
      Research, Prevention and Clinical Network-ISPRO, Florence, Italy.
FAU - Grioni, Sara
AU  - Grioni S
AD  - Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori 
      di Milano, Milan, Italy.
FAU - Tumino, Rosario
AU  - Tumino R
AD  - Cancer Registry and Histopathology Department, "Civic-M.P. Arezzo" Hospital, ASP 
      Ragusa, Ragusa, Italy.
FAU - Naccarati, Alessio
AU  - Naccarati A
AD  - Molecular and Genetic Epidemiology Unit, Italian Institute for Genomic Medicine 
      (IIGM), Turin, Italy.
FAU - Panico, Salvatore
AU  - Panico S
AD  - Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, 
      Italy.
FAU - Vermeulen, Roel
AU  - Vermeulen R
AD  - Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The 
      Netherlands.
FAU - Quiros, J Ramon
AU  - Quiros JR
AD  - Public Health Directorate, Asturias, Spain.
FAU - Rodriguez-Barranco, Miguel
AU  - Rodriguez-Barranco M
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
AD  - Escuela Andaluza de Salud Publica (EASP), Instituto de Investigacion Biosanitaria 
      ibs.GRANADA, Granada, Spain.
FAU - Colorado-Yohar, Sandra M
AU  - Colorado-Yohar SM
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
AD  - Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, 
      Murcia, Spain.
AD  - National Faculty of Public Health, University of Antioquia, Medellin, Colombia.
FAU - Chirlaque, Maria-Dolores
AU  - Chirlaque MD
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
AD  - Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, 
      Murcia, Spain.
AD  - Department of Health and Social Sciences, University of Murcia, Murcia, Spain.
FAU - Ardanaz, Eva
AU  - Ardanaz E
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
AD  - Navarra Public Health Institute, Pamplona, Spain.
AD  - IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
FAU - Wareham, Nick
AU  - Wareham N
AD  - MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, 
      Cambridge, UK.
FAU - Key, Tim
AU  - Key T
AD  - Cancer Epidemiology Unit, Nuffield Department of Population Health, University of 
      Oxford, Oxford, UK.
FAU - Johansson, Mattias
AU  - Johansson M
AD  - International Agency for Research on Cancer (IARC), World Health Organization, 
      Lyon, France.
FAU - Murphy, Neil
AU  - Murphy N
AD  - International Agency for Research on Cancer (IARC), World Health Organization, 
      Lyon, France.
FAU - Ferrari, Pietro
AU  - Ferrari P
AD  - International Agency for Research on Cancer (IARC), World Health Organization, 
      Lyon, France.
FAU - Huybrechts, Inge
AU  - Huybrechts I
AD  - International Agency for Research on Cancer (IARC), World Health Organization, 
      Lyon, France.
FAU - Chajes, Veronique
AU  - Chajes V
AD  - International Agency for Research on Cancer (IARC), World Health Organization, 
      Lyon, France.
FAU - Gonzalez, Carlos Alberto
AU  - Gonzalez CA
AD  - Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), 
      Barcelona, Spain.
FAU - Bueno-de-Mesquita, Bas
AU  - Bueno-de-Mesquita B
AD  - Department for Determinants of Chronic Diseases (DCD), National Institute for 
      Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
FAU - Gunter, Marc
AU  - Gunter M
AD  - International Agency for Research on Cancer (IARC), World Health Organization, 
      Lyon, France.
FAU - Weiderpass, Elisabete
AU  - Weiderpass E
AD  - International Agency for Research on Cancer (IARC), World Health Organization, 
      Lyon, France.
FAU - Riboli, Elio
AU  - Riboli E
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Imperial 
      College London, London, UK.
FAU - Duell, Eric J
AU  - Duell EJ
AD  - Oncology Data Analytics Program, Catalan Institute of Oncology (ICO-IDIBELL), 
      Barcelona, Spain.
FAU - Katzke, Verena
AU  - Katzke V
AD  - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 
      Heidelberg, Germany.
FAU - Vineis, Paolo
AU  - Vineis P
AUID- ORCID: 0000-0001-8935-4566
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Imperial 
      College London, London, UK.
AD  - Molecular and Genetic Epidemiology Unit, Italian Institute for Genomic Medicine 
      (IIGM), Turin, Italy.
LA  - eng
GR  - MC_UU_00006/1/MRC_/Medical Research Council/United Kingdom
GR  - MR/N003284/1/MRC_/Medical Research Council/United Kingdom
GR  - G0401527/MRC_/Medical Research Council/United Kingdom
GR  - G1000143/MRC_/Medical Research Council/United Kingdom
GR  - 14136/CRUK_/Cancer Research UK/United Kingdom
GR  - MR/S019669/1/MRC_/Medical Research Council/United Kingdom
GR  - 001/WHO_/World Health Organization/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Epidemiol
JT  - International journal of epidemiology
JID - 7802871
RN  - 0 (Environmental Pollutants)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Case-Control Studies
MH  - *Environmental Pollutants
MH  - Humans
MH  - *Pancreatic Neoplasms/epidemiology
MH  - Persistent Organic Pollutants
MH  - *Pesticides
MH  - *Polychlorinated Biphenyls
PMC - PMC9082788
OTO - NOTNLM
OT  - Pancreatic cancer
OT  - biomarkers
OT  - environmental health
OT  - methods
OT  - persistent organic pollutants
EDAT- 2021/07/15 06:00
MHDA- 2022/05/12 06:00
PMCR- 2021/07/14
CRDT- 2021/07/14 12:25
PHST- 2021/05/15 00:00 [accepted]
PHST- 2021/07/15 06:00 [pubmed]
PHST- 2022/05/12 06:00 [medline]
PHST- 2021/07/14 12:25 [entrez]
PHST- 2021/07/14 00:00 [pmc-release]
AID - 6321178 [pii]
AID - dyab115 [pii]
AID - 10.1093/ije/dyab115 [doi]
PST - ppublish
SO  - Int J Epidemiol. 2022 May 9;51(2):479-490. doi: 10.1093/ije/dyab115.