PMID- 34260542 OWN - NLM STAT- MEDLINE DCOM- 20210729 LR - 20230103 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 100 IP - 28 DP - 2021 Jul 16 TI - Effects of deferred versus immediate stenting on left ventricular function in patients with ST elevation myocardial infarction. PG - e26598 LID - 10.1097/MD.0000000000026598 [doi] LID - e26598 AB - BACKGROUND: Previous studies have shown conflicting results on the benefits of deferred stenting (DS) in infarct size and the incidence of microvascular obstruction in patients with ST elevation myocardial infarction (STEMI). However, effect of DS on left ventricular (LV) function was not known. We aimed to evaluate whether DS improve LV function and relevant clinical outcomes after STEMI, using follow-up data from the INNOVATION study (NCT02324348). METHODS: In total, 114 patients were randomly assigned to DS group or immediate stenting (IS) group at a 1:1 ratio. LV functional remodeling indices and MACE (major adverse cardiac events: a composite of death, non-fatal MI, unplanned target vessel revascularization, or hospitalization due to heart failure) were compared between DS and IS groups. RESULTS: Serial echocardiographic analyses were completed in 89 subjects (78%). There were no significant changes in LV volume in either group. While LV ejection fraction and wall motion score index (WMSI) improved in both groups during follow-up, the increments were not statistically different between the 2 groups (4.3 +/- 8.2 vs 3.2 +/- 7.1, P = .504 for DeltaLV ejection fraction; -0.16 +/- 0.25 vs -0.16 +/- 0.25, P = .99 for DeltaWMSI). However, E/e'' was decreased and e' was increased only in the DS group (-3.31 +/- 5.60 vs -0.46 +/- 3.10, P = .005 for DeltaE/e'; 0.77 +/- 1.71 vs -0.22 +/- 1.64, P = .009 for Deltae'). The incidence of major adverse cardiac events was numerically lower in the DS group than in the IS group without a statistical significance at 1-year follow-up. CONCLUSIONS: Routine DS improved LV diastolic function but not systolic function compared with IS in patients with STEMI. CI - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Kook, Hyungdon AU - Kook H AD - Division of Cardiology, Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea. FAU - Lee, Hyun-Jong AU - Lee HJ AUID- ORCID: 0000-0003-1260-0778 AD - Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea. FAU - Kim, Mi-Na AU - Kim MN AD - Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital, Korea University School of Medicine, Seoul, Republic of Korea. FAU - Yu, Cheol Woong AU - Yu CW AUID- ORCID: 0000-0002-5871-4562 AD - Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital, Korea University School of Medicine, Seoul, Republic of Korea. FAU - Kim, Je Sang AU - Kim JS AD - Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea. FAU - Joo, Hyung Joon AU - Joo HJ AD - Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital, Korea University School of Medicine, Seoul, Republic of Korea. FAU - Park, Jae Hyoung AU - Park JH AD - Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital, Korea University School of Medicine, Seoul, Republic of Korea. FAU - Hong, Soon Jun AU - Hong SJ AD - Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital, Korea University School of Medicine, Seoul, Republic of Korea. FAU - Kim, Tae Hoon AU - Kim TH AD - Division of Cardiology, Department of Internal Medicine, Cha University School of Medicine, Goyang, Republic of Korea. FAU - Jang, Ho-Jun AU - Jang HJ AD - Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea. FAU - Park, Jin-Shik AU - Park JS AD - Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea. FAU - Choi, Rak Kyeong AU - Choi RK AD - Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea. FAU - Choi, Young Jin AU - Choi YJ AD - Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea. FAU - Kim, Yang Min AU - Kim YM AD - Department of Radiology, Sejong General Hospital, Bucheon, Republic of Korea. FAU - Lim, Do-Sun AU - Lim DS AD - Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital, Korea University School of Medicine, Seoul, Republic of Korea. FAU - Ro, Young Moo AU - Ro YM AD - Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea. LA - eng SI - ClinicalTrials.gov/NCT02324348 PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Aged MH - Echocardiography MH - Female MH - Hospitalization/statistics & numerical data MH - Humans MH - Male MH - Middle Aged MH - Prospective Studies MH - ST Elevation Myocardial Infarction/*surgery MH - Stents/*statistics & numerical data MH - Stroke Volume MH - Time Factors MH - Time-to-Treatment/*statistics & numerical data MH - Ventricular Function, Left/*physiology MH - Ventricular Remodeling/physiology PMC - PMC8284705 EDAT- 2021/07/15 06:00 MHDA- 2021/07/30 06:00 PMCR- 2021/07/16 CRDT- 2021/07/14 17:28 PHST- 2021/01/26 00:00 [received] PHST- 2021/06/21 00:00 [accepted] PHST- 2021/07/14 17:28 [entrez] PHST- 2021/07/15 06:00 [pubmed] PHST- 2021/07/30 06:00 [medline] PHST- 2021/07/16 00:00 [pmc-release] AID - 00005792-202107160-00025 [pii] AID - MD-D-21-00741 [pii] AID - 10.1097/MD.0000000000026598 [doi] PST - ppublish SO - Medicine (Baltimore). 2021 Jul 16;100(28):e26598. doi: 10.1097/MD.0000000000026598.