PMID- 34261591
OWN - NLM
STAT- MEDLINE
DCOM- 20210917
LR  - 20220902
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 154
DP  - 2021 Sep 1
TI  - Usefulness of a Novel Risk Score to Predict In-Hospital Mortality in Patients >/= 
      60 Years of Age with ST Elevation Myocardial Infarction.
PG  - 1-6
LID - S0002-9149(21)00515-4 [pii]
LID - 10.1016/j.amjcard.2021.05.036 [doi]
AB  - Numerous algorithms are available to predict short-term mortality in ST elevation 
      myocardial infarction (STEMI) but none are focused on elderly patients or include 
      invasive hemodynamics. A simplified risk score (LASH score) including left 
      ventricular end diastolic pressure > 20 mm Hg, age > 75 years, systolic blood 
      pressure < 100 mm Hg and heart rate > 100 bpm was tested in a retrospective, 
      single-center study of 346 patients >/= 60 years old who underwent primary 
      percutaneous coronary intervention (PPCI). The median age was 70 years [IQR: 64, 
      79], 60.1% were men, and 77.8% identified as White. In-hospital all-cause 
      mortality was 10.1%. Patients with a LASH score >/= 3 (n = 34) had an in-hospital 
      mortality rate of 44.1% compared to 6.4% for LASH score </= 2 (p < 0.0001). The 
      odds ratio for in-hospital mortality for patients with LASH score >/= 3 was 13.2 
      (95% CI 5.3-33.1) compared to patients with a LASH score </= 2 when adjusted for 
      sex, cardiac arrest, heart failure, and prior cerebrovascular event. The LASH 
      score had an area under the ROC curve for predicting in-hospital mortality of 
      0.795 [CI 0.716-0.872], as compared to TIMI-STEMI (0.881, CI 0.829-0.931; 
      p = 0.01), GRACE (0.849, CI 0.778-0.920; p = 0.19), shock index (0.769, CI 
      0.667-0.871; p = 0.51) and modified shock index (0.765, CI 0.716-0.873; 
      p = 0.48). In summary, a simplified, easy to calculate risk score that 
      incorporates age and invasive hemodynamics predicts in-hospital mortality in 
      patients >/= 60 years old undergoing PPCI for STEMI.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Millo, Lorena
AU  - Millo L
AD  - Division of Cardiology and McAllister Heart Institute, University of North 
      Carolina School of Medicine, Chapel Hill, North Carolina.
FAU - McKenzie, Alexander
AU  - McKenzie A
AD  - Division of Cardiology and McAllister Heart Institute, University of North 
      Carolina School of Medicine, Chapel Hill, North Carolina.
FAU - De la Paz, Andrew
AU  - De la Paz A
AD  - Division of Cardiology and McAllister Heart Institute, University of North 
      Carolina School of Medicine, Chapel Hill, North Carolina.
FAU - Zhou, Cynthia
AU  - Zhou C
AD  - Division of Cardiology and McAllister Heart Institute, University of North 
      Carolina School of Medicine, Chapel Hill, North Carolina.
FAU - Yeung, Michael
AU  - Yeung M
AD  - Division of Cardiology and McAllister Heart Institute, University of North 
      Carolina School of Medicine, Chapel Hill, North Carolina.
FAU - Stouffer, George A
AU  - Stouffer GA
AD  - Division of Cardiology and McAllister Heart Institute, University of North 
      Carolina School of Medicine, Chapel Hill, North Carolina. Electronic address: 
      rstouff@med.unc.edu.
LA  - eng
GR  - T35 AG038047/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20210712
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - *Blood Pressure
MH  - Female
MH  - *Heart Rate
MH  - *Hospital Mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Percutaneous Coronary Intervention
MH  - Retrospective Studies
MH  - Risk Factors
MH  - ST Elevation Myocardial Infarction/physiopathology/*surgery
MH  - Systole
MH  - *Ventricular Pressure
PMC - PMC8349877
MID - NIHMS1714826
COIS- Declaration of interests The authors declare that they have no known competing 
      financial interests or personal relationships that could have appeared to 
      influence the work reported in this paper.
EDAT- 2021/07/16 06:00
MHDA- 2021/09/18 06:00
PMCR- 2022/09/01
CRDT- 2021/07/15 05:36
PHST- 2021/03/31 00:00 [received]
PHST- 2021/05/24 00:00 [revised]
PHST- 2021/05/26 00:00 [accepted]
PHST- 2021/07/16 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2021/07/15 05:36 [entrez]
PHST- 2022/09/01 00:00 [pmc-release]
AID - S0002-9149(21)00515-4 [pii]
AID - 10.1016/j.amjcard.2021.05.036 [doi]
PST - ppublish
SO  - Am J Cardiol. 2021 Sep 1;154:1-6. doi: 10.1016/j.amjcard.2021.05.036. Epub 2021 
      Jul 12.