PMID- 34262657
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210716
IS  - 1976-8354 (Print)
IS  - 2151-2485 (Electronic)
IS  - 1976-8354 (Linking)
VI  - 25
IP  - 3
DP  - 2021
TI  - Polyhexamethylene guanidine phosphate, chloromethylisothiazolinone, and 
      particulate matter are dispensable for stress granule formation in human airway 
      epithelial cells.
PG  - 146-151
LID - 10.1080/19768354.2021.1931442 [doi]
AB  - Environmental risk factors are recognized as threats to public health. Stress 
      granules (SGs) are non-membranous assemblies of mRNAs and proteins expressed in 
      response to various stressors to promote cell survival. In this study, SG 
      formation was examined to confirm the effects of polyhexamethylene guanidine 
      phosphate (PHMG), chloromethylisothiazolinone (CMIT), and particulate matter 
      (PM10) in airway epithelial cells, A549, HPAEpiC, and BEAS-2B cells. SGs were not 
      observed after CMIT, PHMG, and PM10 treatments, as determined by 
      immunofluorescence microscopy. Moreover, there was no change in the 
      phosphorylation of the translation initiation factor eIF2alphafollowing treatment 
      with PHMG, CMIT, and PM10. Taken together, our findings might help determine the 
      biological hazards of these materials.
CI  - (c) 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & 
      Francis Group.
FAU - Cambronero-Urena, Arnoldo
AU  - Cambronero-Urena A
AD  - Department of Biochemistry, Chungnam National University, Daejeon, South Korea.
FAU - Choi, Sunkyung
AU  - Choi S
AD  - Department of Biochemistry, Chungnam National University, Daejeon, South Korea.
FAU - Choi, Seri
AU  - Choi S
AD  - Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon, 
      South Korea.
FAU - Kim, Kee K
AU  - Kim KK
AUID- ORCID: 0000-0002-1088-3383
AD  - Department of Biochemistry, Chungnam National University, Daejeon, South Korea.
FAU - Kim, Eun-Mi
AU  - Kim EM
AD  - Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon, 
      South Korea.
LA  - eng
PT  - Journal Article
DEP - 20210526
PL  - England
TA  - Anim Cells Syst (Seoul)
JT  - Animal cells and systems
JID - 101478641
PMC - PMC8253204
OTO - NOTNLM
OT  - Chloromethylisothiazolinone
OT  - Particulate matter
OT  - Polyhexamethylene guanidine phosphate
OT  - Stress granule
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2021/07/16 06:00
MHDA- 2021/07/16 06:01
PMCR- 2021/05/26
CRDT- 2021/07/15 06:20
PHST- 2021/07/15 06:20 [entrez]
PHST- 2021/07/16 06:00 [pubmed]
PHST- 2021/07/16 06:01 [medline]
PHST- 2021/05/26 00:00 [pmc-release]
AID - 1931442 [pii]
AID - 10.1080/19768354.2021.1931442 [doi]
PST - epublish
SO  - Anim Cells Syst (Seoul). 2021 May 26;25(3):146-151. doi: 
      10.1080/19768354.2021.1931442. eCollection 2021.