PMID- 34262679
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220424
IS  - 2040-6223 (Print)
IS  - 2040-6231 (Electronic)
IS  - 2040-6223 (Linking)
VI  - 12
DP  - 2021
TI  - A cross-sectional study: an assessment of low muscle mass and osteoporosis in 
      type 2 diabetes mellitus patients with a high glycated hemoglobin level.
PG  - 20406223211026762
LID - 10.1177/20406223211026762 [doi]
LID - 20406223211026762
AB  - BACKGROUND: Low muscle mass and osteoporosis are commonly observed in individuals 
      with type 2 diabetes mellitus (T2DM). We investigated the prevalence of low 
      muscle mass and osteoporosis in patients with T2DM who had high glycated 
      hemoglobin (HbA1c) levels. METHODS: We included 187 Chinese patients with T2DM 
      who were aged ⩾50 years and evaluated their body composition using dual-energy 
      X-ray absorptiometry. We measured levels of fasting blood glucose, HbA1c, B 
      collagen-specific sequences (B-CTX), osteocalcin (OC), propeptide of type 1 
      procollagen (P1NP), and 25-hydroxy vitamin D. RESULTS: Of the total patients, 82 
      were men and 105 were women. The prevalence rates of low muscle mass, osteopenia, 
      and osteoporosis were 35.8%, 38.0%, and 31.0%, respectively. The prevalence rate 
      of low muscle mass was significantly higher in women with HbA1c levels >9.0% than 
      in those with HbA1c levels <9.0%. The prevalence rates of osteopenia and 
      osteoporosis in men with HbA1c levels >9.0% differed significantly from those 
      with HbA1c levels <9.0%. The appendicular skeletal muscle mass index (ASMI), 
      trunk muscle mass, lumbar spinal bone mineral content (BMC), lumbar spine BMD, 
      femoral BMC, and femoral BMD were significantly decreased, and the serum levels 
      of B-CTX, OC, and P1NP were significantly increased in patients with T2DM who had 
      osteoporosis. The ASMI was associated with osteopenia/osteoporosis in men and 
      women with T2DM. CONCLUSIONS: In patients with T2DM, high HbA1c levels were 
      associated with higher prevalence rates of low muscle mass in women and 
      osteoporosis in men, and ASMI was a risk factor of osteoporosis.
CI  - (c) The Author(s), 2021.
FAU - Fang, Lingna
AU  - Fang L
AUID- ORCID: 0000-0002-4540-2631
AD  - Department of Endocrinology and Metabolism, Kunshan Hospital Affiliated with 
      Jiangsu University, Qianjin Road 91#, Kunshan, 215300, China.
FAU - Zhong, Shao
AU  - Zhong S
AD  - Department of Endocrinology and Metabolism, Kunshan Hospital Affiliated with 
      Jiangsu University, Kunshan, China.
FAU - Ma, Dan
AU  - Ma D
AD  - Department of Endocrinology and Metabolism, Kunshan Hospital Affiliated with 
      Jiangsu University, Kunshan, China.
FAU - Li, Chong
AU  - Li C
AD  - Department of Orthopaedics, Kunshan Hospital Affiliated with Jiangsu University, 
      Kunshan, China.
FAU - Hao, Yanmin
AU  - Hao Y
AD  - Department of Orthopaedics, Kunshan Hospital Affiliated with Jiangsu University, 
      Kunshan, China.
FAU - Gao, Yan
AU  - Gao Y
AD  - Department of Orthopaedics, Kunshan Hospital Affiliated with Jiangsu University, 
      Kunshan, China.
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Endocrinology and Metabolism, Kunshan Hospital Affiliated with 
      Jiangsu University, Kunshan, China.
FAU - Shen, Liwen
AU  - Shen L
AD  - Department of Endocrinology and Metabolism, Kunshan Hospital Affiliated with 
      Jiangsu University, Kunshan, China.
LA  - eng
PT  - Journal Article
DEP - 20210623
PL  - United States
TA  - Ther Adv Chronic Dis
JT  - Therapeutic advances in chronic disease
JID - 101532140
PMC - PMC8246566
OTO - NOTNLM
OT  - glycated hemoglobin
OT  - low muscle mass
OT  - osteoporosis
OT  - type 2 diabetes mellitus
COIS- Conflict of interest statement: The authors declare that there is no conflict of 
      interest.
EDAT- 2021/07/16 06:00
MHDA- 2021/07/16 06:01
PMCR- 2021/06/23
CRDT- 2021/07/15 06:21
PHST- 2021/01/10 00:00 [received]
PHST- 2021/06/02 00:00 [accepted]
PHST- 2021/07/15 06:21 [entrez]
PHST- 2021/07/16 06:00 [pubmed]
PHST- 2021/07/16 06:01 [medline]
PHST- 2021/06/23 00:00 [pmc-release]
AID - 10.1177_20406223211026762 [pii]
AID - 10.1177/20406223211026762 [doi]
PST - epublish
SO  - Ther Adv Chronic Dis. 2021 Jun 23;12:20406223211026762. doi: 
      10.1177/20406223211026762. eCollection 2021.