PMID- 34264155
OWN - NLM
STAT- MEDLINE
DCOM- 20220301
LR  - 20220301
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 47
IP  - 1
DP  - 2022 Jan
TI  - Elevated Serum Immunoglobulin E Levels are Associated with the Severity of Newly 
      Diagnosed, Acute Vogt-Koyanagi-Harada Disease.
PG  - 102-106
LID - 10.1080/02713683.2021.1951299 [doi]
AB  - OBJECTIVE: To investigate the correlation between serum immunoglobulin E (IgE) 
      levels and severity of Vogt-Koyanagi-Harada (VKH) disease. METHODS: The medical 
      records of patients with VKH disease between 2015 and 2020 were reviewed. Serum 
      immunoglobulins (IgA, IgE, IgG, and IgM), tumor necrosis factor alpha (TNFalpha) and 
      C-reactive protein (CRP) were measured. Patients were divided into IgE-positive 
      (IgE >/= 100 IU/mL) and IgE-negative (IgE < 100 IU/mL) groups. The best-corrected 
      visual acuity (BCVA) and macular morphologic characteristics including foveal 
      thickness (FT), serous retinal detachment (SRD), sensory retinal thickness (SRT), 
      central foveal thickness (CFT), cube volume (V), and cube average thickness (AT) 
      were determined in patients in both groups. RESULTS: Of 128 patients included in 
      the study, 35 (27.34%) patients were IgE-positive, BCVA (logMAR) was worse in the 
      IgE-positive group. The mean CRP (P= .012) and TNFalpha (P</= 0.001) levels were 
      greater in the IgE-positive group than in the IgE-negative group. Regarding 
      macular morphologic characteristics, FT (P= .010), SDR (P= .004), CFT (P= .008), 
      V (P= .013), and AT (P= .006) were significantly greater in the IgE-positive 
      group than in the IgE-negative group. CONCLUSIONS: Elevated serum IgE levels were 
      associated with more severe macular changes in patients with VKH disease. These 
      findings suggest that IgE may be involved in the progression of VKH disease.
FAU - Ji, Huiying
AU  - Ji H
AD  - Department of Laboratory, Shanghai Xuhui Central Hospital, Shanghai, China.
FAU - Zhang, Nan
AU  - Zhang N
AD  - Department of Ophthalmology, Shanghai Xuhui Central Hospital, Shanghai, China.
FAU - Zhu, Maoli
AU  - Zhu M
AD  - Department of Ophthalmology, Shanghai Xuhui Central Hospital, Shanghai, China.
FAU - Dong, Jianhong
AU  - Dong J
AD  - Department of Ophthalmology, Shanghai Xuhui Central Hospital, Shanghai, China.
FAU - Jiang, Zhijian
AU  - Jiang Z
AD  - Department of Ophthalmology, Shanghai Xuhui Central Hospital, Shanghai, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210719
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Biomarkers/blood
MH  - Disease Progression
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Macula Lutea/*diagnostic imaging
MH  - Male
MH  - Patient Acuity
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - Uveomeningoencephalitic Syndrome/*blood/diagnosis/physiopathology
MH  - *Visual Acuity
OTO - NOTNLM
OT  - Vogt-Koyanagi-Harada disease
OT  - immunoglobulin E
OT  - optical coherence tomography
EDAT- 2021/07/16 06:00
MHDA- 2022/03/03 06:00
CRDT- 2021/07/15 12:13
PHST- 2021/07/16 06:00 [pubmed]
PHST- 2022/03/03 06:00 [medline]
PHST- 2021/07/15 12:13 [entrez]
AID - 10.1080/02713683.2021.1951299 [doi]
PST - ppublish
SO  - Curr Eye Res. 2022 Jan;47(1):102-106. doi: 10.1080/02713683.2021.1951299. Epub 
      2021 Jul 19.