PMID- 34267466
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 0971-4502 (Print)
IS  - 0974-0449 (Electronic)
IS  - 0971-4502 (Linking)
VI  - 37
IP  - 3
DP  - 2021 Jul
TI  - Role of Red Cell Indices in Screening for Beta Thalassemia Trait: an Assessment 
      of the Individual Indices and Application of Machine Learning Algorithm.
PG  - 453-457
LID - 10.1007/s12288-020-01373-x [doi]
AB  - Antenatal screening for beta thalassemia trait (BTT) followed by counseling of 
      couples is an efficient way of thalassemia control. Since high performance liquid 
      chromatography (HPLC) is costly, other cost-effective screening methods need to 
      be devised for this purpose. The present study was aimed at evaluating the 
      utility of red cell indices and machine learning algorithms including an 
      artificial neural network (ANN) in detection of BTT among antenatal women. This 
      cross-sectional study included all antenatal women undergoing thalassemia 
      screening at a tertiary care hospital. Complete blood count followed by HPLC was 
      performed. Receiver operating characteristic (ROC) curve analysis was performed 
      for obtaining optimal cutoff for each of the indices with determination of test 
      characteristics for detection of BTT. Machine learning algorithms including C4.5 
      and Naive Bayes (NB) classifier and a back-propagation type ANN including the red 
      cell indices was designed and tested. Over a period of 15 months, 3947 patients 
      underwent thalassemia screening. BTT was diagnosed in 5.98% of women on the basis 
      of HPLC. ROC analysis yielded the maximum accuracy of 63.8%, sensitivity and 
      specificity of 66.2% and 63.7%, respectively for Mean corpuscular hemoglobin 
      concentration (MCHC). The C4.5 and NB classifier had accuracy of 88.56%-82.49% 
      respectively while ANN had an overall accuracy of 85.95%, sensitivity of 83.81%, 
      and specificity of 88.10% in detection of BTT. The present study highlights that 
      none of the red cell parameters standalone is useful for screening for BTT. 
      However, ANN with combination of all the red cell indices had an appreciable 
      sensitivity and specificity for this purpose. Further refinements of the neural 
      network can provide an appropriate tool for use in peripheral settings for 
      thalassemia screening.
CI  - (c) Indian Society of Hematology and Blood Transfusion 2020.
FAU - Jahan, Aarzoo
AU  - Jahan A
AD  - Department of Pathology, Hindu Rao Hospital, Delhi, India. GRID: grid.414109.9. 
      ISNI: 0000 0004 1791 9689
FAU - Singh, Garima
AU  - Singh G
AD  - Department of Pathology, Hindu Rao Hospital, Delhi, India. GRID: grid.414109.9. 
      ISNI: 0000 0004 1791 9689
FAU - Gupta, Ruchika
AU  - Gupta R
AUID- ORCID: 0000-0003-0235-063X
AD  - Division of Cytopathology, ICMR-National Institute of Cancer Prevention and 
      Research, Noida, India. GRID: grid.501268.8
FAU - Sarin, Namrata
AU  - Sarin N
AD  - Department of Pathology, Hindu Rao Hospital, Delhi, India. GRID: grid.414109.9. 
      ISNI: 0000 0004 1791 9689
FAU - Singh, Sompal
AU  - Singh S
AD  - Department of Pathology, Hindu Rao Hospital, Delhi, India. GRID: grid.414109.9. 
      ISNI: 0000 0004 1791 9689
LA  - eng
PT  - Journal Article
DEP - 20201027
PL  - India
TA  - Indian J Hematol Blood Transfus
JT  - Indian journal of hematology & blood transfusion : an official journal of Indian 
      Society of Hematology and Blood Transfusion
JID - 9425818
PMC - PMC8239087
OTO - NOTNLM
OT  - Beta thalassemia trait
OT  - Machine learning algorithm
OT  - Red cell indices
COIS- Conflict of interestThe authors confirm that there are no conflicts of interests 
      to declare.
EDAT- 2021/07/17 06:00
MHDA- 2021/07/17 06:01
PMCR- 2022/07/01
CRDT- 2021/07/16 06:33
PHST- 2020/07/03 00:00 [received]
PHST- 2020/10/20 00:00 [accepted]
PHST- 2021/07/16 06:33 [entrez]
PHST- 2021/07/17 06:00 [pubmed]
PHST- 2021/07/17 06:01 [medline]
PHST- 2022/07/01 00:00 [pmc-release]
AID - 1373 [pii]
AID - 10.1007/s12288-020-01373-x [doi]
PST - ppublish
SO  - Indian J Hematol Blood Transfus. 2021 Jul;37(3):453-457. doi: 
      10.1007/s12288-020-01373-x. Epub 2020 Oct 27.