PMID- 34267632
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210717
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 15
DP  - 2021
TI  - How Self-Appraisal Is Mediated by the Brain.
PG  - 700046
LID - 10.3389/fnhum.2021.700046 [doi]
LID - 700046
AB  - Self-appraisal is a process that leads to the formation of self-esteem, which 
      contributes to subjective well-being and mental health. Neuroimaging studies link 
      self-esteem with the activity of the medial prefrontal cortex (MPFC), right 
      temporoparietal junction (rTPJ), posterior cingulate cortex (PCC), anterior 
      insula (AIns), and dorsolateral prefrontal cortex. It is not known, however, how 
      the process of self-appraisal itself is mediated by the brain and how different 
      nodes of the self-appraisal network interact with each other. In this study, we 
      used multilevel mediation analysis of functional MRI data recorded during the 
      trait adjective judgment task, treating the emotional valence of adjectives as 
      the predictor, behavioral response as the dependent variable, and brain activity 
      as the mediator. The mediation effect was revealed in the rTPJ. Dynamic causal 
      modeling showed that positive self-descriptions trigger communication within the 
      network, with the rTPJ exerting the strongest excitatory output and MPFC 
      receiving the strongest excitatory input. rAIns receives the strongest inhibitory 
      input and sends exclusively inhibitory connections to other regions pointing out 
      to its role in the processing of negative self-descriptions. Analysis of 
      individual differences showed that in some individuals, self-appraisal is mostly 
      driven by the endorsement of positive self-descriptions and is accompanied by 
      increased activation and communication between rTPJ, MPFC, and PCC. In others, 
      self-appraisal is driven by the rejection of negative self-descriptions and is 
      accompanied by increased activation of rAIns and inhibition of PCC and MPFC. 
      Membership of these groups was predicted by different personality variables. This 
      evidence uncovers different mechanisms of positive self-bias, which may 
      contribute to different facets of self-esteem and are associated with different 
      personality profiles.
CI  - Copyright (c) 2021 Knyazev, Savostyanov, Bocharov and Rudych.
FAU - Knyazev, Gennady G
AU  - Knyazev GG
AD  - Laboratory of Psychophysiology of Individual Differences, Federal State Budgetary 
      Scientific Institution Scientific Research Institute of Neurosciences and 
      Medicine, Novosibirsk, Russia.
FAU - Savostyanov, Alexander N
AU  - Savostyanov AN
AD  - Laboratory of Psychophysiology of Individual Differences, Federal State Budgetary 
      Scientific Institution Scientific Research Institute of Neurosciences and 
      Medicine, Novosibirsk, Russia.
AD  - Humanitarian Institute, Novosibirsk State University, Novosibirsk, Russia.
AD  - Laboratory of Psychological Genetics at the Institute of Cytology and Genetics 
      Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
FAU - Bocharov, Andrey V
AU  - Bocharov AV
AD  - Laboratory of Psychophysiology of Individual Differences, Federal State Budgetary 
      Scientific Institution Scientific Research Institute of Neurosciences and 
      Medicine, Novosibirsk, Russia.
AD  - Humanitarian Institute, Novosibirsk State University, Novosibirsk, Russia.
FAU - Rudych, Pavel D
AU  - Rudych PD
AD  - Laboratory of Psychophysiology of Individual Differences, Federal State Budgetary 
      Scientific Institution Scientific Research Institute of Neurosciences and 
      Medicine, Novosibirsk, Russia.
LA  - eng
PT  - Journal Article
DEP - 20210629
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC8275999
OTO - NOTNLM
OT  - DCM
OT  - fMRI
OT  - multilevel mediation analysis
OT  - self-esteem
OT  - self-referential processing
OT  - trait adjective judgment task
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/07/17 06:00
MHDA- 2021/07/17 06:01
PMCR- 2021/01/01
CRDT- 2021/07/16 06:36
PHST- 2021/04/27 00:00 [received]
PHST- 2021/06/03 00:00 [accepted]
PHST- 2021/07/16 06:36 [entrez]
PHST- 2021/07/17 06:00 [pubmed]
PHST- 2021/07/17 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2021.700046 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2021 Jun 29;15:700046. doi: 10.3389/fnhum.2021.700046. 
      eCollection 2021.