PMID- 34268044
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210717
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 13
IP  - 6
DP  - 2021 Jun
TI  - Systemic Lupus Erythematosus With Multi-Organ Involvement in a Young Female: 
      Lymphadenopathy, Lupus Cerebritis, Lupus Nephritis, and Cardiac Manifestations.
PG  - e15517
LID - 10.7759/cureus.15517 [doi]
LID - e15517
AB  - Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease that can 
      affect almost every organ in the body. Its complications can often be fatal. The 
      fatal complications include lupus cerebritis, lupus nephritis, and cardiac 
      manifestations such as pericardial effusion. In this report, we discuss the case 
      of a 23-year-old female who presented with complaints of high-grade fever, 
      seizures, and altered mental state (AMS) and was found to have generalized 
      lymphadenopathy (LAP). Various blood and urine analyses and radiological findings 
      (chest X-ray, MRI of the head) were suggestive of lupus nephritis, lupus 
      cerebritis, massive pericardial effusion, and thrombocytopenia. Her anti-double 
      stranded DNA (anti-dsDNA) antibody was positive, and her pericardial fluid was 
      positive for anti-nuclear antibodies (ANAs). She was administered IV 
      glucocorticoids and phenytoin. She reported improvements in her symptoms 
      gradually for a few days but eventually succumbed to the disease. Although 
      generalized LAP is a rare initial presentation of SLE, it should be included in 
      the differential diagnosis of the disease.
CI  - Copyright (c) 2021, Muhammad et al.
FAU - Muhammad, Owaise
AU  - Muhammad O
AD  - General Medicine, Lugansk State Medical University, Kyiv, UKR.
FAU - Jindal, Himanshu
AU  - Jindal H
AD  - Internal Medicine, Ganesh Shankar Vidyarthi Memorial Medical College, Kanpur, 
      IND.
FAU - Sharath, Medha
AU  - Sharath M
AD  - Internal Medicine, Bangalore Medical College and Research Institute, Bangalore, 
      IND.
FAU - Khan, Aadil M
AU  - Khan AM
AD  - Internal Medicine, Ganesh Shankar Vidyarthi Memorial Medical College, Kanpur, 
      IND.
FAU - Choi, Sarang
AU  - Choi S
AD  - Internal Medicine, The Medical City, Pasig City, PHL.
LA  - eng
PT  - Case Reports
DEP - 20210608
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC8265184
OTO - NOTNLM
OT  - ana
OT  - anti-ds dna
OT  - lupus cerebritis
OT  - lupus nephritis
OT  - lymphadenopathy
OT  - systemic lupus erythematosus
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/07/17 06:00
MHDA- 2021/07/17 06:01
PMCR- 2021/06/08
CRDT- 2021/07/16 06:39
PHST- 2021/06/08 00:00 [accepted]
PHST- 2021/07/16 06:39 [entrez]
PHST- 2021/07/17 06:00 [pubmed]
PHST- 2021/07/17 06:01 [medline]
PHST- 2021/06/08 00:00 [pmc-release]
AID - 10.7759/cureus.15517 [doi]
PST - epublish
SO  - Cureus. 2021 Jun 8;13(6):e15517. doi: 10.7759/cureus.15517. eCollection 2021 Jun.