PMID- 34270700
OWN - NLM
STAT- MEDLINE
DCOM- 20220413
LR  - 20220525
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Print)
IS  - 1462-0324 (Linking)
VI  - 61
IP  - 4
DP  - 2022 Apr 11
TI  - Socio-demographic determinants in the evolution of pain in inflammatory rheumatic 
      diseases: results from ESPOIR and DESIR cohorts.
PG  - 1496-1509
LID - 10.1093/rheumatology/keab562 [doi]
AB  - OBJECTIVE: To determine whether socio-demographic factors are associated with 
      heterogeneity in pain evolution in inflammatory rheumatic diseases (IRDs) after 
      accounting for disease-specific characteristics in a system with universal health 
      care. METHODS: This analysis included the data from two prospective observational 
      cohorts of early IRDs (ESPOIR for early RA and DESIR for early SpA). Data on pain 
      was measured, respectively, on 13 and 9 occasions spanning 10 and 6 years of 
      follow-up using the Short-Form 36 bodily pain score for 810 participants of 
      ESPOIR, and 679 participants of DESIR. Linear mixed models were used to 
      characterize differences in pain evolution as a function of age (tertiles), sex, 
      ethnicity, education, marital, and professional status, after accounting for 
      disease-related, treatment, lifestyle, and health factors. RESULTS: While 
      transitioning from early (disease duration </=6 months for RA and </=3 years for SpA) 
      to long-standing disease, differences in pain evolution emerged as a function of 
      age (P < 0.001), sex (P = 0.050), and ethnicity (P = 0.001) in RA, and as a 
      function of age (P = 0.048) in SpA; younger age, males, and Caucasians exhibited 
      lower pain in the latter phases of both diseases. Highly educated participants 
      (RA, beta = -3.8, P = 0.007; SpA, beta = -6.0, P < 0.001) for both diseases, and 
      Caucasians (beta = -5.6, P = 0.021) for SpA presented with low pain early in the 
      disease, with no changes throughout disease course. CONCLUSION: Being older, 
      female, non-Caucasian and having lower education was found to be associated with 
      worse pain in early and/or long-standing IRDs, despite universally accessible 
      health-care. Early identification of at-risk populations and implementation of 
      multidisciplinary strategies may reduce patient-reported health outcome 
      disparities. TRIAL REGISTRATION REGISTRATIONS: ESPOIR: ClinicalTrials.gov, 
      www.clinicaltrials.gov, NCT03666091. DESIR: ClinicalTrials.gov, 
      www.clinicaltrials.gov, NCT01648907.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      British Society for Rheumatology.
FAU - Kumaradev, Sushmithadev
AU  - Kumaradev S
AUID- ORCID: 0000-0002-0418-4287
AD  - Clinical Epidemiology Applied to Rheumatic and Musculoskeletal Diseases.
AD  - Epidemiology of Ageing and Neurodegenerative Diseases, Inserm 1153, Universite de 
      Paris.
FAU - Roux, Christian
AU  - Roux C
AD  - Clinical Epidemiology Applied to Rheumatic and Musculoskeletal Diseases.
AD  - Department of Rheumatology, APHP-Centre, Cochin Hospital.
FAU - Sellam, Jeremie
AU  - Sellam J
AD  - Department of Rheumatology, APHP-Centre, Saint-Antoine Hospital.
FAU - Perrot, Serge
AU  - Perrot S
AD  - Pain Clinic, APHP-Centre, INSERM U897, Cochin Hospital, Paris.
FAU - Pham, Thao
AU  - Pham T
AD  - Department of Rheumatology, APHM, Sainte-Marguerite Hospital, Aix-Marseille Univ, 
      Marseille, France.
FAU - Dugravot, Aline
AU  - Dugravot A
AD  - Epidemiology of Ageing and Neurodegenerative Diseases, Inserm 1153, Universite de 
      Paris.
FAU - Molto, Anna
AU  - Molto A
AD  - Clinical Epidemiology Applied to Rheumatic and Musculoskeletal Diseases.
AD  - Department of Rheumatology, APHP-Centre, Cochin Hospital.
LA  - eng
SI  - ClinicalTrials.gov/NCT01648907
SI  - ClinicalTrials.gov/NCT03666091
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
SB  - IM
MH  - Demography
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Male
MH  - Pain/etiology
MH  - *Rheumatic Fever
MH  - *Spondylarthritis
PMC - PMC8996788
OTO - NOTNLM
OT  - pain evolution
OT  - pain outcome
OT  - rheumatoid arthritis
OT  - socio-demographic factors
OT  - spondyloarthritis
EDAT- 2021/07/17 06:00
MHDA- 2022/04/14 06:00
PMCR- 2021/07/16
CRDT- 2021/07/16 17:55
PHST- 2021/02/23 00:00 [received]
PHST- 2021/05/30 00:00 [revised]
PHST- 2021/07/17 06:00 [pubmed]
PHST- 2022/04/14 06:00 [medline]
PHST- 2021/07/16 17:55 [entrez]
PHST- 2021/07/16 00:00 [pmc-release]
AID - 6323005 [pii]
AID - keab562 [pii]
AID - 10.1093/rheumatology/keab562 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2022 Apr 11;61(4):1496-1509. doi: 
      10.1093/rheumatology/keab562.