PMID- 34270763
OWN - NLM
STAT- MEDLINE
DCOM- 20220330
LR  - 20220401
IS  - 1749-5024 (Electronic)
IS  - 1749-5016 (Print)
IS  - 1749-5016 (Linking)
VI  - 17
IP  - 2
DP  - 2022 Feb 15
TI  - Negative overgeneralization is associated with anxiety and mechanisms of pattern 
      completion in peripubertal youth.
PG  - 231-240
LID - 10.1093/scan/nsab089 [doi]
AB  - This study examines neural mechanisms of negative overgeneralization, the 
      increased likelihood of generalizing negative information, in peri-puberty. 
      Theories suggest that weak pattern separation [overlapping representations are 
      made distinct, indexed by dentate gyrus/ cornu ammonis (CA)3 hippocampal subfield 
      activation] underlies negative overgeneralization. We alternatively propose that 
      neuro-maturational changes that favor pattern completion (cues reinstate stored 
      representations, indexed by CA1 activation) are modulated by circuitry involved 
      in emotional responding [amygdala, medial prefrontal cortices (mPFC)] to drive 
      negative overgeneralization. Youth (n = 34, 9-14 years) recruited from community 
      and clinic settings participated in an emotional mnemonic similarity task while 
      undergoing magnetic resonance imaging. At study, participants indicated the 
      valence of images; at test, participants made recognition memory judgments. 
      Critical lure stimuli, which were similar to images at study, were presented at 
      test, and errors ('false alarms') to negative relative to neutral stimuli 
      reflected negative overgeneralization. Negative overgeneralization was related to 
      greater and more similar patterns of activation in CA1 and both dorsal mPFC 
      (dmPFC)and ventral mPFC (vmPFC) for negative relative to neutral stimuli. At 
      study, amygdala exhibited greater functional coupling with CA1 and dmPFC during 
      negative items that were later generalized. Negative overgeneralization is rooted 
      in amygdala and mPFC modulation at encoding and pattern completion at retrieval.
CI  - (c) The Author(s) 2021. Published by Oxford University Press.
FAU - McMakin, Dana L
AU  - McMakin DL
AD  - Cognitive Neuroscience Program, Department of Psychology, Florida International 
      University, Miami, FL 33199, USA.
AD  - Clinical Science Program, Department of Psychology, Florida International 
      University, Miami, FL 33199, USA.
AD  - Center for Children and Families, Florida International University, Miami, FL 
      33199, USA.
FAU - Kimbler, Adam
AU  - Kimbler A
AUID- ORCID: 0000-0001-5885-9596
AD  - Cognitive Neuroscience Program, Department of Psychology, Florida International 
      University, Miami, FL 33199, USA.
FAU - Tustison, Nicholas J
AU  - Tustison NJ
AD  - Department of Radiology and Medical Imaging, University of Virginia, 
      Charlottesville, VA 22903, USA.
FAU - Pettit, Jeremy W
AU  - Pettit JW
AD  - Clinical Science Program, Department of Psychology, Florida International 
      University, Miami, FL 33199, USA.
AD  - Center for Children and Families, Florida International University, Miami, FL 
      33199, USA.
FAU - Mattfeld, Aaron T
AU  - Mattfeld AT
AUID- ORCID: 0000-0003-4024-8249
AD  - Cognitive Neuroscience Program, Department of Psychology, Florida International 
      University, Miami, FL 33199, USA.
AD  - Center for Children and Families, Florida International University, Miami, FL 
      33199, USA.
LA  - eng
GR  - R01 MH116005/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Soc Cogn Affect Neurosci
JT  - Social cognitive and affective neuroscience
JID - 101288795
SB  - IM
MH  - Adolescent
MH  - Amygdala/diagnostic imaging
MH  - *Anxiety
MH  - *Anxiety Disorders
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Memory/physiology
MH  - Prefrontal Cortex/physiology
PMC - PMC8847909
OTO - NOTNLM
OT  - anxiety
OT  - fMRI
OT  - generalization
OT  - hippocampus
OT  - mPFC
OT  - pattern completion
EDAT- 2021/07/17 06:00
MHDA- 2022/03/31 06:00
PMCR- 2021/07/16
CRDT- 2021/07/16 17:58
PHST- 2020/12/02 00:00 [received]
PHST- 2021/06/01 00:00 [revised]
PHST- 2021/07/15 00:00 [accepted]
PHST- 2021/07/17 06:00 [pubmed]
PHST- 2022/03/31 06:00 [medline]
PHST- 2021/07/16 17:58 [entrez]
PHST- 2021/07/16 00:00 [pmc-release]
AID - 6322857 [pii]
AID - nsab089 [pii]
AID - 10.1093/scan/nsab089 [doi]
PST - ppublish
SO  - Soc Cogn Affect Neurosci. 2022 Feb 15;17(2):231-240. doi: 10.1093/scan/nsab089.