PMID- 34273093
OWN - NLM
STAT- MEDLINE
DCOM- 20210906
LR  - 20220531
IS  - 1865-8652 (Electronic)
IS  - 0741-238X (Print)
IS  - 0741-238X (Linking)
VI  - 38
IP  - 8
DP  - 2021 Aug
TI  - Possible Preventative/Rehabilitative Role of Gliflozins in OSA and T2DM. A 
      Systematic Literature Review-Based Hypothesis.
PG  - 4195-4214
LID - 10.1007/s12325-021-01791-x [doi]
AB  - Obstructive sleep apnoea (OSA) is characterized by frequent apnoea episodes 
      during sleep due to upper airway obstruction. The present review summarizes 
      current knowledge on inter-relationships between OSA and type 2 diabetes mellitus 
      (T2DM) and suggests the former as a possible target for sodium-glucose 
      co-transporter-2 inhibitors (SGLT-2i). Based on pathophysiological mechanisms 
      underlying OSA onset and renal SGLT-2 effects, we suggest that SGLT-2i 
      indications might expand beyond current ones, including glucose, lipids, uric 
      acid, blood pressure, and body weight control as well as chronic heart failure 
      and kidney disease prevention.
CI  - (c) 2021. The Author(s).
FAU - Monda, Vincenzo Maria
AU  - Monda VM
AD  - Diabetes Unit "Santissima Annunziata" Hospital Cento, Ferrara, Italy.
FAU - Porcellati, Francesca
AU  - Porcellati F
AD  - Section of Internal Medicine, Endocrinology and Metabolism, Department of 
      Medicine, Perugia University School of Medicine, Perugia, Italy.
FAU - Strollo, Felice
AU  - Strollo F
AD  - Endocrinology and Diabetes, IRCCS San Raffaele Pisana, Rome, Italy.
FAU - Fucili, Alessandro
AU  - Fucili A
AD  - Cardiovascular Research Center, Ferrara University, Ferrara, Italy.
FAU - Monesi, Marcello
AU  - Monesi M
AD  - Diabetes Unit "Sant'Anna" Hospital Ferrara, Ferrara, Italy.
FAU - Satta, Ersilia
AU  - Satta E
AD  - Nefrocenter Research and Nyx Start-Up, Naples, Italy.
AD  - Multi-Specialty Nephrology Center (CNP) SrL, Frattamaggiore, Italy.
FAU - Gentile, Sandro
AU  - Gentile S
AUID- ORCID: 0000-0002-9059-6121
AD  - Nefrocenter Research and Nyx Start-Up, Naples, Italy. s.gentile1949@gmail.com.
AD  - Department of Internal Medicine, Campania University "Luigi Vanvitelli", Caserta, 
      Italy. s.gentile1949@gmail.com.
LA  - eng
SI  - figshare/10.6084/m9.figshare.14547447
PT  - Journal Article
DEP - 20210717
PL  - United States
TA  - Adv Ther
JT  - Advances in therapy
JID - 8611864
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Sodium-Glucose Transporter 2 Inhibitors)
RN  - IY9XDZ35W2 (Glucose)
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy
MH  - Glucose
MH  - *Heart Failure
MH  - Humans
MH  - Hypoglycemic Agents
MH  - *Sleep Apnea, Obstructive/complications
MH  - *Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
MH  - Systematic Reviews as Topic
PMC - PMC8342338
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Obstructive sleep apnoea
OT  - Rehabilitation
OT  - Renal function
OT  - SGLT-2i
OT  - Vascular disease
EDAT- 2021/07/18 06:00
MHDA- 2021/09/07 06:00
PMCR- 2021/07/17
CRDT- 2021/07/17 12:10
PHST- 2021/04/14 00:00 [received]
PHST- 2021/05/13 00:00 [accepted]
PHST- 2021/07/18 06:00 [pubmed]
PHST- 2021/09/07 06:00 [medline]
PHST- 2021/07/17 12:10 [entrez]
PHST- 2021/07/17 00:00 [pmc-release]
AID - 10.1007/s12325-021-01791-x [pii]
AID - 1791 [pii]
AID - 10.1007/s12325-021-01791-x [doi]
PST - ppublish
SO  - Adv Ther. 2021 Aug;38(8):4195-4214. doi: 10.1007/s12325-021-01791-x. Epub 2021 
      Jul 17.