PMID- 34273212 OWN - NLM STAT- MEDLINE DCOM- 20220216 LR - 20220216 IS - 1872-8081 (Electronic) IS - 0951-6433 (Linking) VI - 47 IP - 5 DP - 2021 Sep TI - Factors determining the serum 25-hydroxyvitamin D response to vitamin D supplementation: Data mining approach. PG - 828-836 LID - 10.1002/biof.1770 [doi] AB - Vitamin D supplementation has been shown to prevent vitamin D deficiency, but various factors can affect the response to supplementation. Data mining is a statistical method for pulling out information from large databases. We aimed to evaluate the factors influencing serum 25-hydroxyvitamin D levels in response to supplementation of vitamin D using a random forest (RF) model. Data were extracted from the survey of ultraviolet intake by nutritional approach study. Vitamin D levels were measured at baseline and at the end of study to evaluate the responsiveness. We examined the relationship between 76 potential influencing factors on vitamin D response using RF. We found several features that were highly correlated to the serum vitamin D response to supplementation by RF including anthropometric factors (body mass index [BMI], free fat mass [FFM], fat percentage, waist-to-hip ratio [WHR]), liver function tests (serum gamma-glutamyl transferase [GGT], total bilirubin, total protein), hematological parameters (mean corpuscular volume [MCV], mean corpuscular hemoglobin concentration [MCHC], hematocrit), and measurement of insulin sensitivity (homeostatic model assessment of insulin resistance). BMI, total bilirubin, FFM, and GGT were found to have a positive relationship and homeostatic model assessment for insulin resistance, MCV, MCHC, fat percentage, total protein, and WHR were found to have a negative correlation to vitamin D concentration in response to supplementation. The accuracy of RF in predicting the response was 93% compared to logistic regression, for which the accuracy was 40%, in the evaluation of the correlation of the components of the data set to serum vitamin D. CI - (c) 2021 International Union of Biochemistry and Molecular Biology. FAU - Amiri, Zahra AU - Amiri Z AD - Department of Pure Mathematics, Center of Excellence in Analysis on Algebraic Structures (CEAAS), Ferdowsi University of Mashhad, Mashhad, Iran. AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Nosrati, Mina AU - Nosrati M AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Sharifan, Payam AU - Sharifan P AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Saffar Soflaei, Sara AU - Saffar Soflaei S AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Darroudi, Susan AU - Darroudi S AUID- ORCID: 0000-0002-5377-729X AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Ghazizadeh, Hamideh AU - Ghazizadeh H AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Mohammadi Bajgiran, Maryam AU - Mohammadi Bajgiran M AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Moafian, Fahimeh AU - Moafian F AD - Department of Pure Mathematics, Center of Excellence in Analysis on Algebraic Structures (CEAAS), Ferdowsi University of Mashhad, Mashhad, Iran. AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Tayefi, Maryam AU - Tayefi M AD - Norwegian Center for e-health Research, University hospital of North Norway, Tromso, Norway. FAU - Hasanzade, Elahe AU - Hasanzade E AD - Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Rafiee, Mahdi AU - Rafiee M AD - Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Ferns, Gordon A AU - Ferns GA AD - Division of Medical Education, Brighton & Sussex Medical School, Brighton, UK. FAU - Esmaily, Habibollah AU - Esmaily H AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Amini, Mahnaz AU - Amini M AD - Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Ghayour-Mobarhan, Majid AU - Ghayour-Mobarhan M AUID- ORCID: 0000-0002-1081-6754 AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. LA - eng GR - National Institutes for Medical Research Development (NIMAD), Tehran, Iran/ GR - 957705/Elite Researcher Grant Committee/ PT - Journal Article DEP - 20210717 PL - Netherlands TA - Biofactors JT - BioFactors (Oxford, England) JID - 8807441 RN - 0 (Vitamins) RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Adult MH - Body Mass Index MH - *Data Mining MH - Dietary Supplements MH - Female MH - Humans MH - Insulin Resistance MH - Male MH - Middle Aged MH - Obesity/blood/complications MH - Treatment Outcome MH - Vitamin D/*analogs & derivatives/blood/therapeutic use MH - Vitamin D Deficiency/blood/complications/*drug therapy MH - Vitamins/blood/therapeutic use OTO - NOTNLM OT - data mining OT - random forest OT - vitamin D EDAT- 2021/07/18 06:00 MHDA- 2022/02/17 06:00 CRDT- 2021/07/17 17:07 PHST- 2021/04/24 00:00 [received] PHST- 2021/07/01 00:00 [accepted] PHST- 2021/07/18 06:00 [pubmed] PHST- 2022/02/17 06:00 [medline] PHST- 2021/07/17 17:07 [entrez] AID - 10.1002/biof.1770 [doi] PST - ppublish SO - Biofactors. 2021 Sep;47(5):828-836. doi: 10.1002/biof.1770. Epub 2021 Jul 17.