PMID- 34274071
OWN - NLM
STAT- MEDLINE
DCOM- 20210726
LR  - 20210726
IS  - 1873-4111 (Electronic)
IS  - 0378-5122 (Linking)
VI  - 150
DP  - 2021 Aug
TI  - Screening for intrinsic capacity impairments as markers of increased risk of 
      frailty and disability in the context of integrated care for older people: 
      Secondary analysis of MAPT.
PG  - 1-6
LID - S0378-5122(21)00081-5 [pii]
LID - 10.1016/j.maturitas.2021.05.011 [doi]
AB  - AIM: This longitudinal secondary analysis of the Multidomain Alzheimer Preventive 
      Trial (MAPT) aimed to test whether the Integrated Care for Older People (ICOPE) 
      Step 1 screening tool is able to identify people at risk of developing frailty 
      and disability in basic (ADL) and instrumental (IADL) activities of daily living 
      among community-dwelling older adults. PARTICIPANTS AND SETTING: Seven hundred 
      and fifty-nine (n = 759) non-demented participants of the MAPT aged 70-89 years 
      were assessed in memory clinics in France between 2008 and 2013. METHODS: We 
      measured six intrinsic capacity (IC) impairments, adapted from the ICOPE 
      screening tool. We used Cox models to estimate the adjusted hazard ratios of 
      incident frailty and IADL/ADL disability. Incident frailty was defined by Fried's 
      phenotype, and incident disability was measured according to Lawton and Katz for 
      IADLs and ADLs. RESULTS: Limited mobility (HR= 2.97, 95%CI= 1.85-4.76), 
      depressive symptoms (HR= 2.07, 95%CI= 1.03-4.19), and visual impairment (HR= 
      1.70, 95%CI 1.01-2.86) were associated with a higher incidence of frailty over 5 
      years. Each additional IC condition demonstrated a positive association with a 
      higher risk of incident frailty, IADL, ADL disability, with risk increased by 
      47%, 27%, and 23% over 5 years, respectively. CONCLUSION: Screening for IC 
      impairments identifies older adults at higher risk of incident frailty and 
      incident IADL/ADL disability. It is relevant to screen for these impairments 
      together because the risk of frailty and disability increases with each 
      additional one. ClinicalTrials.gov identifier: NCT00672685.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Gonzalez-Bautista, Emmanuel
AU  - Gonzalez-Bautista E
AD  - Gerontopole of Toulouse, Institute of Aging, Toulouse University Hospital (CHU 
      Toulouse), Toulouse, France; UPS/Inserm UMR1027, University of Toulouse III, 
      Toulouse, France. Electronic address: emmanuel.gonzalez-bautista@univ-tlse3.fr.
FAU - de Souto Barreto, Philipe
AU  - de Souto Barreto P
AD  - Gerontopole of Toulouse, Institute of Aging, Toulouse University Hospital (CHU 
      Toulouse), Toulouse, France; UPS/Inserm UMR1027, University of Toulouse III, 
      Toulouse, France. Electronic address: philipebarreto81@yahoo.com.br.
FAU - Andrieu, Sandrine
AU  - Andrieu S
AD  - Gerontopole of Toulouse, Institute of Aging, Toulouse University Hospital (CHU 
      Toulouse), Toulouse, France; UPS/Inserm UMR1027, University of Toulouse III, 
      Toulouse, France. Electronic address: sandrine.andrieu@univ-tlse3.fr.
FAU - Rolland, Yves
AU  - Rolland Y
AD  - Gerontopole of Toulouse, Institute of Aging, Toulouse University Hospital (CHU 
      Toulouse), Toulouse, France; UPS/Inserm UMR1027, University of Toulouse III, 
      Toulouse, France. Electronic address: rolland.y@chu-toulouse.fr.
FAU - Vellas, Bruno
AU  - Vellas B
AD  - Gerontopole of Toulouse, Institute of Aging, Toulouse University Hospital (CHU 
      Toulouse), Toulouse, France; UPS/Inserm UMR1027, University of Toulouse III, 
      Toulouse, France. Electronic address: vellas.b@chu-toulouse.fr.
CN  - MAPT/DSA group (members are listed under 'Contributors')
LA  - eng
SI  - ClinicalTrials.gov/NCT00672685
PT  - Journal Article
DEP - 20210604
PL  - Ireland
TA  - Maturitas
JT  - Maturitas
JID - 7807333
SB  - IM
MH  - *Activities of Daily Living
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*physiopathology
MH  - Delivery of Health Care, Integrated/*statistics & numerical data
MH  - Disabled Persons/*statistics & numerical data
MH  - Female
MH  - Frail Elderly/statistics & numerical data
MH  - Frailty/*diagnosis/*epidemiology
MH  - France/epidemiology
MH  - Humans
MH  - Independent Living
MH  - Longitudinal Studies
MH  - Male
MH  - Mass Screening/*methods
MH  - Randomized Controlled Trials as Topic
MH  - Research Design
OTO - NOTNLM
OT  - Disability
OT  - Frailty
OT  - Functional performance
OT  - ICOPE
OT  - Integrated Care of Older People
OT  - Intrinsic capacity
OT  - Screening
EDAT- 2021/07/19 06:00
MHDA- 2021/07/27 06:00
CRDT- 2021/07/18 20:26
PHST- 2020/09/21 00:00 [received]
PHST- 2021/04/29 00:00 [revised]
PHST- 2021/05/31 00:00 [accepted]
PHST- 2021/07/18 20:26 [entrez]
PHST- 2021/07/19 06:00 [pubmed]
PHST- 2021/07/27 06:00 [medline]
AID - S0378-5122(21)00081-5 [pii]
AID - 10.1016/j.maturitas.2021.05.011 [doi]
PST - ppublish
SO  - Maturitas. 2021 Aug;150:1-6. doi: 10.1016/j.maturitas.2021.05.011. Epub 2021 Jun 
      4.