PMID- 34274085
OWN - NLM
STAT- MEDLINE
DCOM- 20210917
LR  - 20210917
IS  - 2174-2049 (Electronic)
IS  - 2174-2049 (Linking)
VI  - 40
IP  - 6
DP  - 2021 Jun
TI  - Impact of catheter ablation for atrial fibrillation in patients with heart 
      failure and left ventricular systolic dysfunction.
PG  - 437-444
LID - S2174-2049(21)00163-X [pii]
LID - 10.1016/j.repce.2021.07.008 [doi]
AB  - INTRODUCTION AND AIMS: Catheter ablation has been shown to improve left 
      ventricular (LV) ejection fraction (LVEF) in patients with atrial fibrillation 
      (AF) and heart failure (HF). Our aim was to assess the impact of AF ablation on 
      the outcome of patients with HF and LV systolic dysfunction. METHODS: We 
      performed a retrospective observational cohort study of all patients with HF and 
      LVEF <50% and with no apparent cause for systolic dysfunction other than AF who 
      underwent catheter ablation in a tertiary referral center between July 2016 and 
      November 2018. The primary endpoint was a >/=5% improvement in LVEF. Secondary 
      endpoints included improvement in New York Heart Association (NYHA) class and 
      reduction in LV end-diastolic diameter (LVEDD) and left atrial diameter (LAD). 
      RESULTS: Of 153 patients who underwent AF ablation in this period, 22 (77% male, 
      median age 61 [IQR 54-64] years) fulfilled the inclusion criteria. Median 
      follow-up was 11.1 months (IQR 6.1-19.0). After ablation, median LVEF increased 
      from 40% (IQR 33-41) to 58% (IQR 55-62) (p<0.01), mean NYHA class improved from 
      2.35+/-0.49 to 1.3+/-0.47 (p<0.001), and median LAD and LVEDD decreased from 48.0 
      (IQR 43.5-51.5) mm to 44 (IQR 40-49) mm (p<0.01) and from 61.0 (IQR 54.0-64.8) mm 
      to 55.0 (52.2-58.0) mm (p<0.01), respectively. CONCLUSION: In patients with HF 
      and LV systolic dysfunction, AF ablation is associated not only with improved 
      functional status but also with favorable structural remodeling, including 
      improvement in LVEF and decreases in LAD and LVEDD.
CI  - Copyright (c) 2021 Sociedade Portuguesa de Cardiologia. Published by Elsevier 
      Espana, S.L.U. All rights reserved.
FAU - Ribeiro, Joana Maria
AU  - Ribeiro JM
AD  - Cardiology Department, Centro Hospitalar e Universitario de Coimbra, Coimbra, 
      Portugal.
FAU - Sousa, Pedro A
AU  - Sousa PA
AD  - Cardiology Department, Centro Hospitalar e Universitario de Coimbra, Coimbra, 
      Portugal. Electronic address: peter@chuc.min-saude.pt.
FAU - Antonio, Natalia
AU  - Antonio N
AD  - Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
FAU - Baptista, Rui
AU  - Baptista R
AD  - Faculty of Medicine, University of Coimbra, Coimbra, Portugal; iCRB, Faculty of 
      Medicine, University of Coimbra, Coimbra, Portugal.
FAU - Elvas, Luis
AU  - Elvas L
AD  - Cardiology Department, Centro Hospitalar e Universitario de Coimbra, Coimbra, 
      Portugal.
FAU - Barra, Sergio
AU  - Barra S
AD  - Cardiology Department, Hospital da Luz Arrabida, Vila Nova de Gaia, Portugal; 
      Cardiology Department, Centro Hospitalar Vila Nova de Gaia - Espinho, Vila Nova 
      de Gaia, Portugal; Cardiology Department, Royal Papworth Hospital NHS Foundation 
      Trust, Cambridge, United Kingdom.
FAU - Goncalves, Lino
AU  - Goncalves L
AD  - Cardiology Department, Centro Hospitalar e Universitario de Coimbra, Coimbra, 
      Portugal; Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - Spain
TA  - Rev Port Cardiol (Engl Ed)
JT  - Revista portuguesa de cardiologia
JID - 101770878
SB  - IM
CIN - Rev Port Cardiol (Engl Ed). 2021 Jun;40(6):445-446. PMID: 34274086
MH  - *Atrial Fibrillation/surgery
MH  - *Catheter Ablation
MH  - Female
MH  - *Heart Failure/surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Ablacao por cateter
OT  - Atrial fibrillation
OT  - Catheter ablation
OT  - Disfuncao sistolica do ventriculo esquerdo
OT  - Fibrilhacao auricular
OT  - Heart failure
OT  - Insuficiencia cardiaca
OT  - Left ventricular systolic dysfunction
EDAT- 2021/07/19 06:00
MHDA- 2021/09/18 06:00
CRDT- 2021/07/18 20:26
PHST- 2020/01/21 00:00 [received]
PHST- 2020/08/09 00:00 [accepted]
PHST- 2021/07/18 20:26 [entrez]
PHST- 2021/07/19 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
AID - S2174-2049(21)00163-X [pii]
AID - 10.1016/j.repce.2021.07.008 [doi]
PST - ppublish
SO  - Rev Port Cardiol (Engl Ed). 2021 Jun;40(6):437-444. doi: 
      10.1016/j.repce.2021.07.008.