PMID- 34274517
OWN - NLM
STAT- MEDLINE
DCOM- 20220323
LR  - 20220323
IS  - 2451-9030 (Electronic)
IS  - 2451-9022 (Linking)
VI  - 7
IP  - 1
DP  - 2022 Jan
TI  - Neurocognitive Assessments Are More Important Among Adolescents Than Adults for 
      Predicting Psychosis in Clinical High Risk.
PG  - 56-65
LID - S2451-9022(21)00195-6 [pii]
LID - 10.1016/j.bpsc.2021.06.015 [doi]
AB  - BACKGROUND: Few studies have examined the effects of age on neurocognition to 
      predict conversion to psychosis in individuals at clinical high risk (CHR). This 
      study aimed to compare the extent and predictive performance of cognitive 
      deficits between adolescents and adults at CHR. METHODS: A comprehensive 
      neuropsychological battery was performed on 325 CHR individuals and 365 healthy 
      control (HC) subjects. The subjects were first divided into 189 CHR adolescents 
      (age 12-17 years), 136 CHR adults (age 18-45 years), 88 HC adolescents, and 277 
      HC adults. CHR subjects were then divided into converters (CHR-Cs) (adolescents, 
      n = 43; adults, n = 34) and nonconverters (CHR-NCs) (adolescents, n = 146; 
      adults, n = 102) based on their 2-year follow-up clinical status. RESULTS: The 
      adolescents and adults at CHR performed significantly worse than their control 
      groups on all neurocognitive tests, except for performance on the continuous 
      performance test in adolescents. In the comparison between adolescents and 
      adults, patterns of neurocognitive deficits seemed to vary in HC subjects rather 
      than in CHR subjects. In the comparison between CHR and HC subjects, the rank 
      order of effect sizes across the neurocognitive tests was similar for the top two 
      tests of symbol coding and verbal learning. Comparison between CHR-Cs and CHR-NCs 
      revealed that adolescent CHR-Cs performed significantly worse than CHR-NCs on 
      seven of eight neurocognitive tests; however, adult CHR-Cs performed 
      significantly worse than CHR-NCs only in the visuospatial memory test. 
      CONCLUSIONS: The role of neurocognitive dysfunction may have different patterns 
      and weights during the onset of psychosis in adolescents and adults at CHR, 
      implicating the development of specific strategies that could monitor and improve 
      cognitive function in CHR adolescents.
CI  - Copyright (c) 2021 Society of Biological Psychiatry. Published by Elsevier Inc. All 
      rights reserved.
FAU - Zhang, TianHong
AU  - Zhang T
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China. Electronic 
      address: zhang_tianhong@126.com.
FAU - Cui, HuiRu
AU  - Cui H
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
FAU - Wei, YanYan
AU  - Wei Y
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
FAU - Tang, XiaoChen
AU  - Tang X
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
FAU - Xu, LiHua
AU  - Xu L
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
FAU - Hu, YeGang
AU  - Hu Y
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
FAU - Tang, YingYing
AU  - Tang Y
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
FAU - Chen, Tao
AU  - Chen T
AD  - Big Data Research Laboratory, University of Waterloo, Waterloo, Ontario, Canada; 
      Senior Research Fellow, Labor and Worklife Program, Harvard University, 
      Cambridge, Massachusetts; Niacin (Shanghai) Technology Co, Ltd, Shanghai, China.
FAU - Li, ChunBo
AU  - Li C
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
FAU - Wang, JiJun
AU  - Wang J
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China; CAS Center for 
      Excellence in Brain Science and Intelligence Technology, Chinese Academy of 
      Sciences, Shanghai, China; Brain Science and Technology Research Center, Shanghai 
      Jiao Tong University, Shanghai, China. Electronic address: jijunwang27@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210716
PL  - United States
TA  - Biol Psychiatry Cogn Neurosci Neuroimaging
JT  - Biological psychiatry. Cognitive neuroscience and neuroimaging
JID - 101671285
SB  - IM
CIN - Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Jan;7(1):5-6. PMID: 34998483
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - *Cognition Disorders
MH  - *Cognitive Dysfunction
MH  - Humans
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Prodromal Symptoms
MH  - *Psychotic Disorders/psychology
MH  - Young Adult
OTO - NOTNLM
OT  - Age effect
OT  - Transition
OT  - Ultra high risk
OT  - Verbal learning
OT  - Visuospatial memory
EDAT- 2021/07/19 06:00
MHDA- 2022/03/24 06:00
CRDT- 2021/07/18 20:37
PHST- 2021/05/03 00:00 [received]
PHST- 2021/06/17 00:00 [revised]
PHST- 2021/06/30 00:00 [accepted]
PHST- 2021/07/19 06:00 [pubmed]
PHST- 2022/03/24 06:00 [medline]
PHST- 2021/07/18 20:37 [entrez]
AID - S2451-9022(21)00195-6 [pii]
AID - 10.1016/j.bpsc.2021.06.015 [doi]
PST - ppublish
SO  - Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Jan;7(1):56-65. doi: 
      10.1016/j.bpsc.2021.06.015. Epub 2021 Jul 16.