PMID- 34274840
OWN - NLM
STAT- MEDLINE
DCOM- 20210825
LR  - 20210825
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 141
DP  - 2021 Sep
TI  - Disorganization in first episode schizophrenia: Treatment response and 
      psychopathological findings from the 2-year follow-up of the "Parma Early 
      Psychosis" program.
PG  - 293-300
LID - S0022-3956(21)00433-7 [pii]
LID - 10.1016/j.jpsychires.2021.07.015 [doi]
AB  - OBJECTIVE: Disorganization is a core dimension of schizophrenia, yet it is 
      relatively under-investigated compared to positive and negative ones, especially 
      at the illness onset. Indeed, most of the empirical studies investigating the 
      disorganized domain included patients with prolonged schizophrenia. Therefore, 
      the aims of this research were (1) to monitor the longitudinal stability of 
      disorganized symptoms in young patients with First Episode Schizophrenia (FES) 
      along a 2-year follow-up period, and (2) to examine any significant association 
      of disorganization with functioning, psychopathology and the specific treatment 
      components of an "Early Intervention in Psychosis" (EIP) program across the 2 
      years of follow-up. METHODS: At baseline, 159 FES individuals (aged 12-35 years) 
      completed the Positive And Negative Syndrome Scale (PANSS) and the Global 
      Assessment of Functioning (GAF). Spearman's correlation coefficients and multiple 
      linear regression analysis were carried out. RESULTS: During the follow-up 
      period, disorganization had relevant enduring positive associations with PANSS 
      negative symptoms, lack of judgment/insight and positive symptoms representing 
      delusional thought contents, as well as significant enduring negative correlation 
      with GAF scores. Along the 2 years of follow-up, FES patients also showed a 
      relevant improvement in disorganization symptoms. This reduction was specifically 
      associated with the number of individual psychotherapy sessions provided during 
      the first year of treatment. CONCLUSION: Disorganization is a prominent clinical 
      feature in FES at the recruitment in specialized EIP services, but its temporal 
      trajectory reveals a decrease over time, together with the delivery of specific, 
      patient-tailored EIP interventions.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Pelizza, Lorenzo
AU  - Pelizza L
AD  - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, 
      Largo Palli n. 1/A, 43100, Parma, Italy. Electronic address: 
      lorpelizza@ausl.pr.it.
FAU - Leuci, Emanuela
AU  - Leuci E
AD  - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, 
      Largo Palli n. 1/A, 43100, Parma, Italy.
FAU - Maestri, Davide
AU  - Maestri D
AD  - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, 
      Largo Palli n. 1/A, 43100, Parma, Italy.
FAU - Quattrone, Emanuela
AU  - Quattrone E
AD  - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, 
      Largo Palli n. 1/A, 43100, Parma, Italy.
FAU - Azzali, Silvia
AU  - Azzali S
AD  - Department of Mental Health and Pathological Addiction, Azienda USL-IRCCS di 
      Reggio Emilia, Via Amendola n. 2, 43100, Reggio Emilia, Italy.
FAU - Paulillo, Giuseppina
AU  - Paulillo G
AD  - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, 
      Largo Palli n. 1/A, 43100, Parma, Italy.
FAU - Pellegrini, Pietro
AU  - Pellegrini P
AD  - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, 
      Largo Palli n. 1/A, 43100, Parma, Italy.
FAU - Raballo, Andrea
AU  - Raballo A
AD  - Department of Medicine, Division of Psychiatry, Clinical Psychology and 
      Rehabilitation, University of Perugia, Sant'Andrea delle Fratte, 06156, Perugia, 
      PG, Italy; Center for Translational, Phenomenological and Developmental 
      Psychopathology, Perugia University Hospital, Sant'Andrea delle Fratte, 06156, 
      Perugia, PG, Italy.
LA  - eng
PT  - Journal Article
DEP - 20210713
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
SB  - IM
MH  - Follow-Up Studies
MH  - Humans
MH  - Psychopathology
MH  - Psychotherapy
MH  - *Psychotic Disorders/therapy
MH  - *Schizophrenia/therapy
OTO - NOTNLM
OT  - Disorganization
OT  - Early schizophrenia
OT  - First episode schizophrenia
OT  - Follow-up
OT  - Psychopathology
OT  - Treatment response
EDAT- 2021/07/19 06:00
MHDA- 2021/08/26 06:00
CRDT- 2021/07/18 20:50
PHST- 2021/05/22 00:00 [received]
PHST- 2021/07/12 00:00 [accepted]
PHST- 2021/07/19 06:00 [pubmed]
PHST- 2021/08/26 06:00 [medline]
PHST- 2021/07/18 20:50 [entrez]
AID - S0022-3956(21)00433-7 [pii]
AID - 10.1016/j.jpsychires.2021.07.015 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2021 Sep;141:293-300. doi: 10.1016/j.jpsychires.2021.07.015. 
      Epub 2021 Jul 13.