PMID- 34275409
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220424
IS  - 1502-4725 (Electronic)
IS  - 0803-9488 (Linking)
VI  - 76
IP  - 3
DP  - 2022 Apr
TI  - First-episode psychosis integrative treatment: Estonian experience.
PG  - 207-214
LID - 10.1080/08039488.2021.1946139 [doi]
AB  - PURPOSE: Research on first-episode psychosis early intervention has shown 
      significant positive effects on psychopathological, functional and 
      quality-of-life outcome measures. The effects reported have however been 
      short-term and there is still only limited information about the long-term 
      effects. This article will present the short-term results of an effectiveness 
      study in a Baltic country and the first results of a registry-based long-term 
      follow-up. METHODS: One hundred and ninety-nine first-episode psychosis patients 
      were included in the early intervention effectiveness study in 2004-2008, and 107 
      were available for a follow-up after two years. Registry-based ten-year follow-up 
      (n = 116) was conducted with a retrospectively formed control group (n = 114). 
      RESULTS: Patients who received early intervention had substantial symptomatic 
      improvement (BPRS score reduction > 50%) after 6 months of treatment, the Global 
      Assessment of Functioning (GAF) scores were significantly improved after 
      6 months, and the quality of life after 12 months was significantly higher than 
      at the beginning of treatment. After 2 years employment increased by 14% 
      (43.9-57.9%). Long-term follow-up revealed that significantly fewer patients in 
      the intervention group had been in supported housing compared to the control 
      group. Patients in the intervention group had spent more time working during the 
      follow-up period and had almost two times larger incomes, suggestive of higher 
      employment/salary level. CONCLUSIONS: Early intervention with flexible duration 
      has positive long-term effects on the functioning of patients.
FAU - Peebo, Karola
AU  - Peebo K
AUID- ORCID: 0000-0002-6847-8444
AD  - North Estonia Medical Centre, Psychiatry Clinic, Tallinn, Estonia.
AD  - School of Natural Sciences and Health, Tallinn University, Tallinn, Estonia.
FAU - Saluveer, Erika
AU  - Saluveer E
AD  - North Estonia Medical Centre, Psychiatry Clinic, Tallinn, Estonia.
FAU - Kuunarpuu, Harri
AU  - Kuunarpuu H
AD  - North Estonia Medical Centre, Psychiatry Clinic, Tallinn, Estonia.
FAU - Orgse, Teele
AU  - Orgse T
AD  - North Estonia Medical Centre, Psychiatry Clinic, Tallinn, Estonia.
FAU - Harro, Jaanus
AU  - Harro J
AUID- ORCID: 0000-0002-4484-2096
AD  - North Estonia Medical Centre, Psychiatry Clinic, Tallinn, Estonia.
AD  - School of Natural Sciences and Health, Tallinn University, Tallinn, Estonia.
AD  - Chair of Neuropsychopharmacology, Institute of Chemistry, Faculty of Science and 
      Technology, University of Tartu, Tartumaa, Estonia.
LA  - eng
PT  - Journal Article
DEP - 20210718
PL  - England
TA  - Nord J Psychiatry
JT  - Nordic journal of psychiatry
JID - 100927567
SB  - IM
MH  - Estonia
MH  - Humans
MH  - *Psychotic Disorders/diagnosis/therapy
MH  - Quality of Life
MH  - Retrospective Studies
MH  - *Schizophrenia/diagnosis/therapy
OTO - NOTNLM
OT  - First-episode psychosis
OT  - early intervention
OT  - long-term outcomes
EDAT- 2021/07/20 06:00
MHDA- 2022/04/05 06:00
CRDT- 2021/07/19 05:27
PHST- 2021/07/20 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2021/07/19 05:27 [entrez]
AID - 10.1080/08039488.2021.1946139 [doi]
PST - ppublish
SO  - Nord J Psychiatry. 2022 Apr;76(3):207-214. doi: 10.1080/08039488.2021.1946139. 
      Epub 2021 Jul 18.