PMID- 34275846
OWN - NLM
STAT- MEDLINE
DCOM- 20220117
LR  - 20220117
IS  - 1011-601X (Print)
IS  - 1011-601X (Linking)
VI  - 34
IP  - 1(Supplementary)
DP  - 2021 Jan
TI  - Development and Quality evaluation of sustained release pellets of eperisone HCl.
PG  - 225-235
AB  - The objective was to develop eperisone HCl sustained-release pellets through 
      extrusion spheronization technique and to determine the influence of different 
      hydrophobic (polymeric based and wax-based) and hydrophilic (polymeric based) 
      matrix former on the release of eperisone HCl (BCS class I drug) and on pellet 
      sphericity. The pellet formulations consisted of different hydrophobic and 
      hydrophilic matrix formers like HPMC K4M (10-20%) HPMC K15M (10%), EC (7cps) 
      (10-20%), Carnauba wax (10-20%), Compritol ATO 888 (10-20%), Glyceryl 
      monostearate (10%), lactose and microcrystalline cellulose. The initial burst 
      release of the drug from matrix pellet formulations was effectively controlled by 
      coating with 5% EC (ethylcellulose) dispersion. The dissolution profile and drug 
      release kinetics of coated pellet formulations were determined at both acidic and 
      basic pH medium. SEM (Scanning electron microscope) technique was used to 
      determine the surface morphology and cross-section of F5 and F7 pellet 
      formulation. The mechanism of drug release of coated formulation followed 
      non-Fickian diffusion. FTIR spectroscopy was conducted and no drug and excipients 
      interaction was observed. The results had shown that optimized coated formulation 
      was F5 and F7 which effectively extend the drug release for 12 hours.
FAU - Jawed, Syed Hameez
AU  - Jawed SH
AD  - Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, 
      University of Karachi, Karachi, Pakistan.
FAU - Muhammad, Iyad Naeem
AU  - Muhammad IN
AD  - Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, 
      University of Karachi, Karachi, Pakistan.
FAU - Qazi, Faiza
AU  - Qazi F
AD  - Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, 
      University of Karachi, Karachi, Pakistan.
FAU - Shoaib, Muhammad Harris
AU  - Shoaib MH
AD  - Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, 
      University of Karachi, Karachi, Pakistan.
FAU - Arshad, Hafiz Muhammad
AU  - Arshad HM
AD  - Department of Pharmaceutics, Dow College of Pharmacy, DUHS, Karachi, Pakistan.
FAU - Siddiqui, Tuba
AU  - Siddiqui T
AD  - Department of Pharmaceutics, Faculty of Pharmacy, Federal Urdu University of 
      Arts, Science and Technology, Karachi.
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - Pak J Pharm Sci
JT  - Pakistan journal of pharmaceutical sciences
JID - 9426356
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Excipients)
RN  - 0 (Fatty Acids)
RN  - 0 (Glycerides)
RN  - 0 (Muscle Relaxants, Central)
RN  - 0 (Polymers)
RN  - 0 (Propiophenones)
RN  - 0 (Waxes)
RN  - 0 (hydroxypropylmethylcellulose-lactose matrix)
RN  - 18641-57-1 (glyceryl behenate)
RN  - 230OU9XXE4 (glyceryl monostearate)
RN  - 2M2P0551D3 (eperisone)
RN  - 7Z8S9VYZ4B (ethyl cellulose)
RN  - 9004-34-6 (Cellulose)
RN  - 9004-67-5 (Methylcellulose)
RN  - J2B2A4N98G (Lactose)
RN  - OP1R32D61U (microcrystalline cellulose)
RN  - R12CBM0EIZ (carnauba wax)
SB  - IM
MH  - Cellulose/analogs & derivatives
MH  - Chemistry, Pharmaceutical
MH  - Delayed-Action Preparations/chemistry/*pharmacokinetics
MH  - Drug Development
MH  - Drug Liberation
MH  - Excipients/chemistry
MH  - Fatty Acids
MH  - Glycerides
MH  - Lactose/analogs & derivatives
MH  - Methylcellulose/analogs & derivatives
MH  - Microscopy, Electron, Scanning
MH  - Muscle Relaxants, Central/administration & dosage/chemistry/*pharmacokinetics
MH  - Polymers
MH  - Propiophenones/administration & dosage/chemistry/*pharmacokinetics
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Waxes
EDAT- 2021/07/20 06:00
MHDA- 2022/01/18 06:00
CRDT- 2021/07/19 05:42
PHST- 2021/07/19 05:42 [entrez]
PHST- 2021/07/20 06:00 [pubmed]
PHST- 2022/01/18 06:00 [medline]
PST - ppublish
SO  - Pak J Pharm Sci. 2021 Jan;34(1(Supplementary)):225-235.