PMID- 34276312
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210720
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 15
DP  - 2021
TI  - Location Matters: Navigating Regional Heterogeneity of the Neurovascular Unit.
PG  - 696540
LID - 10.3389/fncel.2021.696540 [doi]
LID - 696540
AB  - The neurovascular unit (NVU) of the brain is composed of multiple cell types that 
      act synergistically to modify blood flow to locally match the energy demand of 
      neural activity, as well as to maintain the integrity of the blood-brain barrier 
      (BBB). It is becoming increasingly recognized that the functional specialization, 
      as well as the cellular composition of the NVU varies spatially. This 
      heterogeneity is encountered as variations in vascular and perivascular cells 
      along the arteriole-capillary-venule axis, as well as through differences in NVU 
      composition throughout anatomical regions of the brain. Given the wide variations 
      in metabolic demands between brain regions, especially those of gray vs. white 
      matter, the spatial heterogeneity of the NVU is critical to brain function. Here 
      we review recent evidence demonstrating regional specialization of the NVU 
      between brain regions, by focusing on the heterogeneity of its individual 
      cellular components and briefly discussing novel approaches to investigate NVU 
      diversity.
CI  - Copyright (c) 2021 Bernier, Brunner, Cottarelli and Balbi.
FAU - Bernier, Louis-Philippe
AU  - Bernier LP
AD  - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 
      Vancouver, BC, Canada.
FAU - Brunner, Clement
AU  - Brunner C
AD  - Neuro-Electronics Research Flanders, Leuven, Belgium.
AD  - Vlaams Instituut voor Biotechnologie, Leuven, Belgium.
AD  - Interuniversity Microeletronics Centre, Leuven, Belgium.
AD  - Department of Neurosciences, KU Leuven, Leuven, Belgium.
FAU - Cottarelli, Azzurra
AU  - Cottarelli A
AD  - Irving Medical Center, Columbia University, New York, NY, United States.
FAU - Balbi, Matilde
AU  - Balbi M
AD  - Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210630
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC8277940
OTO - NOTNLM
OT  - astrocytes
OT  - blood-brain barrier
OT  - endothelial cell
OT  - neurovascular unit
OT  - pericytes
OT  - regional heterogeneity
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/07/20 06:00
MHDA- 2021/07/20 06:01
PMCR- 2021/01/01
CRDT- 2021/07/19 05:50
PHST- 2021/04/16 00:00 [received]
PHST- 2021/05/31 00:00 [accepted]
PHST- 2021/07/19 05:50 [entrez]
PHST- 2021/07/20 06:00 [pubmed]
PHST- 2021/07/20 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2021.696540 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2021 Jun 30;15:696540. doi: 10.3389/fncel.2021.696540. 
      eCollection 2021.