PMID- 34276395
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231107
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 12
DP  - 2021
TI  - Matrix Metalloproteinase 3: A Promoting and Destabilizing Factor in the 
      Pathogenesis of Disease and Cell Differentiation.
PG  - 663978
LID - 10.3389/fphys.2021.663978 [doi]
LID - 663978
AB  - Cells must alter their expression profiles and morphological characteristics but 
      also reshape the extracellular matrix (ECM) to fulfill their functions throughout 
      their lifespan. Matrix metalloproteinase 3 (MMP-3) is a member of the matrix 
      metalloproteinase (MMP) family, which can degrade multiple ECM components. MMP-3 
      can activate multiple pro-MMPs and thus initiates the MMP-mediated degradation 
      reactions. In this review, we summarized the function of MMP-3 and discussed its 
      effects on biological activities. From this point of view, we emphasized the 
      positive and negative roles of MMP-3 in the pathogenesis of disease and cell 
      differentiation, highlighting that MMP-3 is especially closely involved in the 
      occurrence and development of osteoarthritis. Then, we discussed some pathways 
      that were shown to regulate MMP-3. By writing this review, we hope to provide new 
      topics of interest for researchers and attract more researchers to investigate 
      MMP-3.
CI  - Copyright (c) 2021 Wan, Zhang, Li, Qiu, Ouyang, Dai and Min.
FAU - Wan, Jiangtao
AU  - Wan J
AD  - Spine Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
FAU - Zhang, Guowei
AU  - Zhang G
AD  - Spine Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
FAU - Li, Xin
AU  - Li X
AD  - Spine Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
FAU - Qiu, Xianshuai
AU  - Qiu X
AD  - Spine Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
FAU - Ouyang, Jun
AU  - Ouyang J
AD  - Guangdong Provincial Key Laboratory of Medical Biomechanics, Department of 
      Anatomy, School of Basic Medical Sciences, Southern Medical University, 
      Guangzhou, China.
FAU - Dai, Jingxing
AU  - Dai J
AD  - Guangdong Provincial Key Laboratory of Medical Biomechanics, Department of 
      Anatomy, School of Basic Medical Sciences, Southern Medical University, 
      Guangzhou, China.
FAU - Min, Shaoxiong
AU  - Min S
AD  - Spine Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210702
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC8283010
OTO - NOTNLM
OT  - cell differentiation
OT  - extracellular matrix
OT  - matrix metalloproteinase 3
OT  - osteoarthritis
OT  - stem cells
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/07/20 06:00
MHDA- 2021/07/20 06:01
PMCR- 2021/07/02
CRDT- 2021/07/19 05:51
PHST- 2021/02/04 00:00 [received]
PHST- 2021/06/10 00:00 [accepted]
PHST- 2021/07/19 05:51 [entrez]
PHST- 2021/07/20 06:00 [pubmed]
PHST- 2021/07/20 06:01 [medline]
PHST- 2021/07/02 00:00 [pmc-release]
AID - 10.3389/fphys.2021.663978 [doi]
PST - epublish
SO  - Front Physiol. 2021 Jul 2;12:663978. doi: 10.3389/fphys.2021.663978. eCollection 
      2021.