PMID- 34277491
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210720
IS  - 2236-1960 (Print)
IS  - 2236-1960 (Electronic)
IS  - 2236-1960 (Linking)
VI  - 11
DP  - 2021
TI  - Secretory carcinoma of the breast, commonly exhibits the features of low grade, 
      triple negative breast carcinoma- A Case report with updated review of 
      literature.
PG  - e2020227
LID - 10.4322/acr.2020.227 [doi]
LID - e2020227
AB  - Secretory carcinoma of the breast (SBC) is a rare breast neoplasm. Most of the 
      patients present at an early stage with a relatively indolent clinical course. 
      Lymph node and distant metastasis are also very infrequent. The 
      histomorphological features of the secretory breast carcinoma are quite 
      characteristic. Predominantly three histological patterns, solid, microcystic, 
      and tubular, have been noted with copious amounts of intra and extracellular 
      secretory material. Most commonly, no positivity for estrogen receptor (ER), 
      progesterone receptor (PR) and ERBB2(HER2/neu) is observed in SBCs. As SBC can 
      occasionally be hormone receptor-positive, they should not be categorized in the 
      triple-negative breast carcinoma (TNBC) group in general. A very characteristic 
      genetic translocation t (12;15) has been noted in this rare tumor, resulting in a 
      fusion between ETV6 and NTRK3 proteins. We present a case of a 60-year-old lady 
      who presented with right breast lump of 1-month duration and was managed by 
      lumpectomy and sentinel lymph node dissection. Axillary dissection was not 
      performed because the sentinel lymph node biopsy was negative. Postoperative 
      radiotherapy was given to the right breast with a boost to the tumor bed. No 
      adjuvant chemotherapy was given No recurrence has been noted even after a year of 
      the completion of treatment.
CI  - Copyright (c) 2020 The Author(s).
FAU - Banerjee, Nirmalya
AU  - Banerjee N
AUID- ORCID: 0000-0001-6557-2956
AD  - Postgraduate Institute of Medical Education and Research, Department of 
      Histopathology, Chandigarh, India.
FAU - Banerjee, Devmalya
AU  - Banerjee D
AUID- ORCID: 0000-0001-9822-3664
AD  - Faculty Department of Oncopathology, NH super-specialty Hospital Howrah, West 
      Bengal, India.
FAU - Choudhary, Neha
AU  - Choudhary N
AUID- ORCID: 0000-0002-3713-0998
AD  - Faculty Department of Oncosurgery, NH super-specialty Howrah, West Bengal, India.
LA  - eng
PT  - Case Reports
DEP - 20201208
PL  - Brazil
TA  - Autops Case Rep
JT  - Autopsy & case reports
JID - 101640070
PMC - PMC8101654
OTO - NOTNLM
OT  - Breast neoplasm
OT  - Secretory component
OT  - Sentinel lymph node biopsy
OT  - Translocation, genetic
COIS- Conflict of interest: none.
EDAT- 2021/07/20 06:00
MHDA- 2021/07/20 06:01
PMCR- 2020/12/08
CRDT- 2021/07/19 05:59
PHST- 2020/05/30 00:00 [received]
PHST- 2020/08/12 00:00 [accepted]
PHST- 2021/07/19 05:59 [entrez]
PHST- 2021/07/20 06:00 [pubmed]
PHST- 2021/07/20 06:01 [medline]
PHST- 2020/12/08 00:00 [pmc-release]
AID - autopsy070920 [pii]
AID - 10.4322/acr.2020.227 [doi]
PST - epublish
SO  - Autops Case Rep. 2020 Dec 8;11:e2020227. doi: 10.4322/acr.2020.227. eCollection 
      2021.