PMID- 34277864
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220425
IS  - 2322-3480 (Print)
IS  - 2322-3480 (Electronic)
IS  - 2322-3480 (Linking)
VI  - 10
IP  - 1
DP  - 2021 Apr
TI  - Lower Serum Irisin Levels Are Associated with Increased Osteoporosis and 
      Oxidative Stress in Postmenopausal.
PG  - 13-19
LID - 10.52547/rbmb.10.1.13 [doi]
AB  - BACKGROUND: Irisin as an exercise-induced myokine was proposed to improve bone 
      health. This study investigated the role of serum irisin (s-irisin) in patients 
      with osteoporosis (OP) through correlating to most biological bone markers and 
      oxidative stress. METHODS: A cross-sectional study recruited an eligible 175 
      postmenopausal women at Al-Hussien Teaching Hospital, Iraq. They were scanned by 
      DEXA and stratified into two groups based on T-score; the first 95 patients as 
      control group (GI) with -1 </= T-score and the second 80 patients as cases group 
      (GII) with T-score </= -2.5. Demographic criteria were age, bone mineral density 
      (BMD, g/cm2) and T-score. Serum irisin, total serum calcium (s-calcium), serum 
      inorganic phosphate (s-phosphate), serum alkaline phosphatase (s-ALP), serum 25 
      [OH] vitamin D, the serum parathyroid hormone (s-PTH), serum Carboxy terminal 
      collagen crosslinks (CTx), serum procollagen type I C-termidnal peptide (s-PICP), 
      serum malondialdehyde (s-MDA) and serum superoxide dismutase (s-SOD) were 
      collected from blood samples. RESULTS: Serum irisin were 31.84 +/- 2.65 vs. 20.88 +/- 
      2.71 ng/mL for control and trial groups, respectively. Lower levels of BMD, 
      T-score, 25 [OH] vitamin D, and s-irisin along with a higher serum levels of PTH, 
      CTx, PICP, MDA and SOD were observed in patients with osteoporosis. All 
      parameters were statistically meaningful upon correlation (p< 0.0001), except age 
      and s-calcium (p= 0.0088 and p= 0.187, respectively). CONCLUSION: The results 
      showed that, a significantly lower serum irisin levels among osteoporosis women, 
      was intimately correlated to most bone turnover markers and it can be considered 
      as encouraging results for clinical application in prediction and treatment of 
      osteoporosis.
FAU - Badr Roomi, Ali
AU  - Badr Roomi A
AD  - PhD, Ministry of Education, Directorate of Education Thi-Qar, Thi-Qar-64001, 
      Iraq.
AD  - College of Health and Medical Technology, Al-Ayen University, Thi-Qar-64001, 
      Iraq.
FAU - Nori, Wassan
AU  - Nori W
AD  - Department of Obstetrics and Gynecology, College of Medicine, Mustansiriyah 
      University, Iraq.
FAU - Mokram Hamed, Roaa
AU  - Mokram Hamed R
AD  - The National Center of Hematology, Mustansiriyah University, Iraq.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Rep Biochem Mol Biol
JT  - Reports of biochemistry & molecular biology
JID - 101637937
PMC - PMC8279710
OTO - NOTNLM
OT  - BMD
OT  - Bone turnover markers
OT  - DEXA scan
OT  - Irisin
OT  - T-score
OT  - osteoporosis
OT  - post-menopause
EDAT- 2021/07/20 06:00
MHDA- 2021/07/20 06:01
PMCR- 2021/04/01
CRDT- 2021/07/19 06:01
PHST- 2020/11/02 00:00 [received]
PHST- 2020/11/22 00:00 [accepted]
PHST- 2021/07/19 06:01 [entrez]
PHST- 2021/07/20 06:00 [pubmed]
PHST- 2021/07/20 06:01 [medline]
PHST- 2021/04/01 00:00 [pmc-release]
AID - rbmb-10-013 [pii]
AID - 10.52547/rbmb.10.1.13 [doi]
PST - ppublish
SO  - Rep Biochem Mol Biol. 2021 Apr;10(1):13-19. doi: 10.52547/rbmb.10.1.13.